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NPM1 wt Allele

Known as: NPM1, B23, Nucleophosmin (Nucleolar Phosphoprotein B23, Numatrin) wt Allele 
Human NPM1 wild-type allele is located in the vicinity of 5q35 and is approximately 24 kb in length. This allele, which encodes nucleophosmin protein… 
National Institutes of Health

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Related topics

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5q35Acute Myeloid Leukemia with Mutated NPM1Leukemia, Myelocytic, AcuteLymphoma, Non-Hodgkin

Broader (1)

NPM1 gene

Papers overview

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Highly Cited
2007
Highly Cited
2007
Oncogenic tyrosine kinase NPM/ALK induces activation of the MEK/ERK signaling pathway independently of c-Raf
The mechanisms of cell transformation mediated by the highly oncogenic, chimeric NPM/ALK tyrosine kinase remain only partially… 
Highly Cited
2003
Highly Cited
2003
Vav-promoter regulated oncogenic fusion protein NPM-ALK in transgenic mice causes B-cell lymphomas with hyperactive Jun kinase
Anaplastic large-cell lymphoma is associated with a chromosomal translocation generating an oncogenic fusion protein: the… 
Highly Cited
2003
Highly Cited
2003
Overexpression of NPM–ALK induces different types of malignant lymphomas in IL-9 transgenic mice
Anaplastic large-cell lymphoma (ALCL) comprises approximately 25% of all non-Hodgkin lymphomas (NHL) in children and young adults… 
Highly Cited
2002
Highly Cited
2002
Nucleophosmin-anaplastic lymphoma kinase (NPM-ALK), a novel Hsp90-client tyrosine kinase: down-regulation of NPM-ALK expression and tyrosine phosphorylation in ALK(+) CD30(+) lymphoma cells by the…
Anaplastic large cell lymphomas (ALCL) are characterized by the expression of a chimeric protein, NPM-ALK, which originates from… 
Highly Cited
2001
Highly Cited
2001
Research Validity Scales for the NEO-PI-R: Additional Evidence for Reliability and Validity
We examined the reliability and validity of the research validity scales (Schinka, Kinder, & Kremer, 1997) for the NEO… 
Highly Cited
1998
Highly Cited
1998
Detection of the t(2;5)‐associated NPM/ALK fusion cDNA in peripheral blood cells of healthy individuals
The translocation t(2;5), which leads to the fusion of the nucleophosmin gene (NPM) on chromosome 5q35 to the receptor kinase ALK… 
Highly Cited
1998
Highly Cited
1998
Characterization of t(2;5) reciprocal transcripts and genomic breakpoints in CD30+ cutaneous lymphoproliferations.
NPM-ALK chimeric transcripts, encoded by the t(2;5), lead to an aberrant expression of ALK by CD30+ systemic lymphomas. To… 
Highly Cited
1997
Highly Cited
1997
Detection of the t(2;5)(p23;q35) and NPM-ALK fusion in non-Hodgkin's lymphoma by two-color fluorescence in situ hybridization.
The non-Hodgkin's lymphoma (NHL) subset commonly referred to as large cell lymphoma (LCL) has historically been characterized by… 
Highly Cited
1995
Highly Cited
1995
Interaction of nucleolar protein B23 with peptides related to nuclear localization signals.
Nucleolar protein B23 is a putative ribosome assembly factor with a high affinity for peptides containing nuclear localization… 
Highly Cited
1986
Highly Cited
1986
New GTO Current Source Inverter with Pulsewidth Modulation Control Techniques
A new GTO current source inverter in which two auxiliary GTO's are added to the basic inverter circuit, which consists of six GTO… 
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