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NOTCH1 protein, human

Known as: Notch Homolog 1, TAN-1, TAN1 protein, human 
Neurogenic locus notch homolog protein 1 (2555 aa, ~273 kDa) is encoded by the human NOTCH1 gene. This protein is involved in both cell-cell… 
National Institutes of Health

Related topics

Related topics

20 relations
Ankyrin RepeatApoptosisCell Differentiation processCell Fate Control

Broader (1)

Receptor, Notch1

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
A hepatocellular carcinoma 5-gene score associated with survival of patients after liver resection.
BACKGROUND & AIMS Due to the phenotypic and molecular diversity of hepatocellular carcinomas (HCC), it is a challenge to… 
Highly Cited
2010
Highly Cited
2010
Regulation of Notch1 Signaling by Nrf2: Implications for Tissue Regeneration
The cell survival pathway mediated by the transcription factor Nrf2 facilitates tissue regeneration by promoting Notch1 signaling… 
Highly Cited
2009
Highly Cited
2009
Numb Regulates Post-endocytic Trafficking and Degradation of Notch1*
Notch is a transmembrane receptor that controls cell fate decisions during development and tissue homeostasis. Both activation… 
Review
2008
Review
2008
The molecular logic of Notch signaling – a structural and biochemical perspective
The Notch signaling pathway constitutes an ancient and conserved mechanism for cell-cell communication in metazoan organisms, and… 
Highly Cited
2002
Highly Cited
2002
Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma.
Notch signaling controls cell fate decisions of hematopoietic progenitors by inhibiting certain steps of differentiation and… 
Highly Cited
2001
Highly Cited
2001
Functional Interaction between SEL-10, an F-box Protein, and the Nuclear Form of Activated Notch1 Receptor*
The Notch signaling pathway is essential in many cell fate decisions in invertebrates as well as in vertebrates. After ligand… 
Highly Cited
2001
Highly Cited
2001
SEL-10 Is an Inhibitor of Notch Signaling That Targets Notch for Ubiquitin-Mediated Protein Degradation
ABSTRACT Notch receptors and their ligands play important roles in both normal animal development and pathogenesis. We show here… 
Highly Cited
1999
Highly Cited
1999
Notch1 inhibits neurite outgrowth in postmitotic primary neurons
Highly Cited
1996
Highly Cited
1996
Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles
Notch is a highly conserved transmembrane protein that is involved in cell fate decisions and is found in organisms ranging from… 
Highly Cited
1996
Highly Cited
1996
Expression Patterns ofJagged, Delta1, Notch1, Notch2,andNotch3Genes Identify Ligand–Receptor Pairs That May Function in Neural Development
Notch genes encode receptors for a signaling pathway that regulates neurogenesis. The DSL (Delta/Serrate/lag-2) genes encode… 
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