NOTCH1 protein, human

Known as: Notch Homolog 1, TAN-1, TAN1 protein, human 
Neurogenic locus notch homolog protein 1 (2555 aa, ~273 kDa) is encoded by the human NOTCH1 gene. This protein is involved in both cell-cell… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1991-2017
010203019912017

Papers overview

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2014
2014
The main oncogenic driver in T-lymphoblastic leukemia is NOTCH1, which activates genes by forming chromatin-associated Notch… (More)
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2008
2008
Heterodimerization domain (HD) mutations in NOTCH1 induce ligand-independent activation of the receptor and contribute to the… (More)
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Highly Cited
2007
Highly Cited
2007
Gain-of-function mutations in NOTCH1 are common in T-cell lymphoblastic leukemias and lymphomas (T-ALL), making this receptor a… (More)
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Highly Cited
2007
Highly Cited
2007
Gene expression profiling of acute myeloid leukemia (AML) allows the discovery of previously unrecognized molecular entities… (More)
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Highly Cited
2006
Highly Cited
2006
The role of NOTCH1 as an oncogene or tumor suppressor appears to be cell type-specific. Medullary thyroid cancer (MTC) cells… (More)
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Highly Cited
2004
Highly Cited
2004
Very rare cases of human T cell acute lymphoblastic leukemia (T-ALL) harbor chromosomal translocations that involve NOTCH1, a… (More)
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Highly Cited
2003
Highly Cited
2003
Glycoprotein130 (gp130) and Notch signaling are thought to participate in neural stem cell (NSC) self-renewal. We asked whether… (More)
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Highly Cited
1996
Highly Cited
1996
Notch is a highly conserved transmembrane protein that is involved in cell fate decisions and is found in organisms ranging from… (More)
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Highly Cited
1994
Highly Cited
1994
Members of the Notch gene family have been shown to mediate cell-fate decisions by multipotent precursors in a number of… (More)
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Highly Cited
1991
Highly Cited
1991
Previously we described joining of DNA in the beta T cell receptor gene to DNA of an uncharacterized locus in a t(7;9)(q34;q34.3… (More)
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