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Receptor, Notch1

Known as: Notch1 Protein, Notch1 Receptor, Receptor, Notch1 [Chemical/Ingredient] 
A notch receptor that interacts with a variety of ligands and regulates SIGNAL TRANSDUCTION PATHWAYS for multiple cellular processes. It is widely… 
National Institutes of Health

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Related topics

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In Bloodagonistsantagonists & inhibitorsaspects of radiation effects

Narrower (3)

NOTCH1 protein, humanNotch1 protein, mousenotch1a protein, zebrafish

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
circ-NOTCH1 acts as a sponge of miR-637 and affects the expression of its target gene Apelin to regulate gastric cancer cell growth.
Recent studies have indicated that circRNAs have important functions in the occurrence and progression of GC. Studies on circ… 
Review
2019
Review
2019
Overview of non‐coding mutations in chronic lymphocytic leukemia
Chronic lymphocytic leukemia (CLL) is the most frequent leukemia type in which the genetic alterations influencing the clinico… 
2017
2017
Development of a peptide-based inducer of protein degradation targeting NOTCH1.
2015
2015
The Notch pathway mediates the angiotensin II-induced synthesis of extracellular matrix components in podocytes.
The Notch pathway is known to contribute to the development of glomerular disease. Angiotensin II (Ang II), an important member… 
Highly Cited
2014
Highly Cited
2014
MiR-139-5p inhibits migration and invasion of colorectal cancer by downregulating AMFR and NOTCH1
MicroRNAs (miRNAs) that exert function by posttranscriptional suppression have recently brought insight in our understanding of… 
Review
2013
Review
2013
Clinical significance of c.7544‐7545 delCT NOTCH1 mutation in chronic lymphocytic leukaemia
Chronic lymphocytic leukaemia (CLL) is a heterogeneous disease with highly variable clinical courses and survivals ranging from… 
Highly Cited
2011
Highly Cited
2011
Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathway
Multiciliated cells lining the surface of some vertebrate epithelia are essential for various physiological processes, such as… 
2011
2011
Probing the druggability of protein-protein interactions: targeting the Notch1 receptor ankyrin domain using a fragment-based approach.
In order to achieve greater selectivity in drug discovery, researchers in both academia and industry are targeting cell… 
Highly Cited
2008
Highly Cited
2008
Aggressive Langerhans cell histiocytosis following T‐ALL: Clonally related neoplasms with persistent expression of constitutively active NOTCH1
Langerhans cell histiocytosis (LCH) and related entities are neoplasms of unknown pathogenesis. Here, we describe studies… 
Highly Cited
1997
Highly Cited
1997
Neoplastic transformation by truncated alleles of human NOTCH1/TAN1 and NOTCH2
The Notch genes of Drosophila melanogaster and vertebrates encode transmembrane receptors that help determine cell fate during… 
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