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The mechanisms by which transcription factor haploinsufficiency alters the epigenetic and transcriptional landscape in human… Expand Significance Triple-negative breast cancers comprise 10% of invasive breast carcinomas but are responsible for a disproportionate… Expand Human breast cancers include cancer stem cell populations as well as nontumorigenic cancer cells. Breast cancer stem cells have… Expand Uterine receptivity implies a dialogue between the hormonally primed maternal endometrium and the free‐floating blastocyst… Expand The bicuspid aortic valve (BAV) is the most common congenital cardiac malformation, occurring in 1-2% of the population. In a… Expand The role of NOTCH1 as an oncogene or tumor suppressor appears to be cell type-specific. Medullary thyroid cancer (MTC) cells… Expand The cell fate determinant Numb influences developmental decisions by antagonizing the Notch signaling pathway. However, the… Expand The Notch intracellular region (RAMIC) interacts with a DNA binding protein RBP-J to activate transcription of genes that inhibit… Expand The Notch genes of Drosophila melanogaster and vertebrates encode transmembrane receptors that help determine cell fate during… Expand Signaling through Notch receptors has been implicated in the control of cellular differentiation in animals ranging from… Expand