Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia
- A. Weng, A. Ferrando, J. Aster
- 8 October 2004
These findings greatly expand the role of activated NOTCH1 in the molecular pathogenesis of human T-ALL and provide a strong rationale for targeted therapies that interfere with NOTCH signaling.
Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning
Genes implicated in DLBCL outcome included some that regulate responses to B-cell–receptor signaling, critical serine/threonine phosphorylation pathways and apoptosis, and identify rational targets for intervention.
Comprehensive analyses of tumor immunity: implications for cancer immunotherapy
- Bo Li, E. Severson, X. Liu
- Biology, MedicineGenome Biology
- 22 August 2016
A computational approach to study tumor-infiltrating immune cells and their interactions with cancer cells is developed and may inform effective cancer vaccine and checkpoint blockade therapies.
An immunogenic personal neoantigen vaccine for patients with melanoma
- P. Ott, Zhuting Hu, Catherine J. Wu
- Biology, MedicineNature
- 5 July 2017
The feasibility, safety, and immunogenicity of a vaccine that targets up to 20 predicted personal tumour neoantigens is demonstrated and a strong rationale for further development of this approach, alone and in combination with checkpoint blockade or other immunotherapies is provided.
NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth
- T. Palomero, W. Lim, A. Ferrando
- BiologyProceedings of the National Academy of Sciences
- 28 November 2006
The NOTCH1 signaling pathway directly links extracellular signals with transcriptional responses in the cell nucleus and plays a critical role during T cell development and in the pathogenesis over…
Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response.
Tumor microenvironment and host inflammatory response as defining features in DLBCL are identified and rational treatment targets in specificDLBCL subsets are suggested.
c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma.
- A. Weng, J. Millholland, J. Aster
- BiologyGenes & Development
- 1 August 2006
Human acute T-cell lymphoblastic leukemias and lymphomas (T-ALL) are commonly associated with gain-of-function mutations in Notch1 that contribute to T-ALL induction and maintenance. Starting from an…
MAML1, a human homologue of Drosophila Mastermind, is a transcriptional co-activator for NOTCH receptors
- Lizi Wu, J. Aster, S. Blacklow, Robert Lake, S. Artavanis-Tsakonas, J. Griffin
- BiologyNature Genetics
- 1 December 2000
Cl clone MAML1, a human homologue of the Drosophila gene Mastermind, and show that it encodes a protein of 130 kD localizing to nuclear bodies that functions as a transcriptional co-activator for NOTCH signalling.
The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymphoma.
A molecular link between MLBCL and cHL and a shared survival pathway is identified and a classifier of these diseases is developed.
Ibrutinib in previously treated Waldenström's macroglobulinemia.
- S. Treon, C. Tripsas, R. Advani
- MedicineNew England Journal of Medicine
- 8 April 2015
Ibrutinib was highly active, associated with durable responses, and safe in pretreated patients with Waldenström's macroglobulinemia, and the effect of MYD88 and CXCR4 mutations on outcomes was investigated.