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NOS3 protein, human

Known as: NOS3, ECNOS protein, human, EC-NOS 
Nitric oxide synthase, endothelial (1203 aa, ~133 kDa) is encoded by the human NOS3 gene. This protein plays a role in the modulation of vascular… 
National Institutes of Health

Related topics

Related topics

17 relations
Angiogenesis PathwayAngiogenic ProcessCorticosteroid Cardioprotection PathwayEnosis

Broader (1)

Nitric Oxide Synthase Type III

Papers overview

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Highly Cited
2006
Highly Cited
2006
Activation of endothelial nitric oxide synthase by cilostazol via a cAMP/protein kinase A- and phosphatidylinositol 3-kinase/Akt-dependent mechanism.
Highly Cited
2006
Highly Cited
2006
Molecular Mechanism of the Inhibitory Effect of Aldosterone on Endothelial NO Synthase Activity
Although the proinflammatory and profibrotic actions of aldosterone (Aldo) on the vasculature have been reported, the effects and… 
Highly Cited
2004
Highly Cited
2004
A Constituent of Green Tea, Epigallocatechin-3-gallate, Activates Endothelial Nitric Oxide Synthase by a Phosphatidylinositol-3-OH-kinase-, cAMP-dependent Protein Kinase-, and Akt-dependent Pathway…
Epidemiological studies suggest that tea catechins may reduce the risk of cardiovascular disease, but the mechanisms of benefit… 
Highly Cited
2004
Highly Cited
2004
Increased Endothelial Tetrahydrobiopterin Synthesis by Targeted Transgenic GTP-Cyclohydrolase I Overexpression Reduces Endothelial Dysfunction and Atherosclerosis in ApoE-Knockout Mice
Objective—Increased production of reactive oxygen species and loss of endothelial nitric oxide (NO) bioactivity are key features… 
Highly Cited
2003
Highly Cited
2003
VEGF induces S1P1 receptors in endothelial cells: Implications for cross-talk between sphingolipid and growth factor receptors
Sphingosine 1-phosphate (S1P) is a platelet-derived sphingolipid that binds to S1P1 (EDG-1) receptors and activates the… 
Highly Cited
2002
Highly Cited
2002
Basal and Stimulated Protein S-Nitrosylation in Multiple Cell Types and Tissues*
There is substantial evidence that proteinS-nitrosylation provides a significant route through which nitric oxide (NO)-derived… 
Highly Cited
2002
Highly Cited
2002
Localization of Endothelial Nitric-oxide Synthase Phosphorylated on Serine 1179 and Nitric Oxide in Golgi and Plasma Membrane Defines the Existence of Two Pools of Active Enzyme*
The subcellular localization of endothelial nitric-oxide synthase (eNOS) is critical for optimal coupling of extracellular… 
Review
2002
Review
2002
Physiological mechanisms regulating the expression of endothelial-type NO synthase.
Highly Cited
2001
Highly Cited
2001
Simvastatin Preserves Coronary Endothelial Function in Hypercholesterolemia in the Absence of Lipid Lowering
Abstract—Recent evidence suggests that some benefit from the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors may occur… 
Highly Cited
2000
Highly Cited
2000
Bradykinin-regulated Interactions of the Mitogen-activated Protein Kinase Pathway with the Endothelial Nitric-oxide Synthase*
Activation of the bradykinin B2 receptor in endothelial cells initiates a complex array of cellular responses mediated by diverse… 
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