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Reactive oxygen species regulate activation-induced T cell apoptosis.
Reactive oxygen species (ROS) mediate apoptosis in a number of cell types. We studied the role that ROS play in activated T cell apoptosis by activating T cells in vivo and then culturing them for a… Expand
Mitochondrial toxicity of nrti antiviral drugs: an integrated cellular perspective
Highly active antiretroviral therapy (HAART) regimes based on nucleoside reverse transcriptase inhibitors (NRTIs) have revolutionized the treatment of AIDS in recent years. Although HAART can… Expand
Requirement for Superoxide in Excitotoxic Cell Death
We tested the pathogenic role of O2-) radicals in excitotoxic injury. Inactivation of the TCA cycle enzyme, aconitase, was used as a marker of intracellular O2- levels, and a porphyrin SOD mimetic… Expand
A mechanism of paraquat toxicity involving nitric oxide synthase.
- B. Day, M. Patel, L. Calavetta, L. Chang, J. Stamler
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 26 October 1999
Paraquat (PQ) is a well described pneumotoxicant that produces toxicity by redox cycling with cellular diaphorases, thereby elevating intracellular levels of superoxide (O-(2)). NO synthase (NOS) has… Expand
On topological quotient maps preserved by pullbacks or products
We are concerned with the category of topological spaces and continuous maps. A surjection f : X → Y in this category is called a quotient map if G is open in Y whenever f −1 G is open in X . Our… Expand
A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase
Reactive oxygen species (ROS) have been implicated in a wide range of degenerative processes including amyotrophic lateral sclerosis, ischemic heart disease, Alzheimer disease, Parkinson disease and… Expand
Metalloporphyrin class of therapeutic catalytic antioxidants.
Metalloporphyrins have emerged as a novel class of catalytic antioxidants that scavenge a wide range of reactive oxygen species (ROS) such as superoxide, peroxide, peroxynitrite and lipid peroxyl… Expand
Catalase and glutathione peroxidase mimics.
- B. Day
- Medicine, Chemistry
- Biochemical pharmacology
- 1 February 2009
Overproduction of the reactive oxygen species (ROS) superoxide (O(2)(-)) and hydrogen peroxide (H(2)O(2)) are increasingly implicated in human disease and aging. ROS are also being explored as… Expand
Basal and Stimulated Protein S-Nitrosylation in Multiple Cell Types and Tissues*
- A. Gow, Q. Chen, D. Hess, B. Day, H. Ischiropoulos, J. Stamler
- Medicine, Biology
- The Journal of Biological Chemistry
- 22 March 2002
There is substantial evidence that proteinS-nitrosylation provides a significant route through which nitric oxide (NO)-derived bioactivity is conveyed. However, most examples of S-nitrosylation have… Expand
Manganic porphyrins possess catalase activity and protect endothelial cells against hydrogen peroxide-mediated injury.
- B. Day, I. Fridovich, J. Crapo
- Chemistry, Medicine
- Archives of biochemistry and biophysics
- 15 November 1997
Manganic porphyrins are redox active metal complexes that have been employed as superoxide dismutase mimics. We tested whether these metalloporphyrins could also dismute hydrogen peroxide (H2O2) and… Expand