• Publications
  • Influence
Reactive oxygen species regulate activation-induced T cell apoptosis.
Reactive oxygen species (ROS) mediate apoptosis in a number of cell types. We studied the role that ROS play in activated T cell apoptosis by activating T cells in vivo and then culturing them for aExpand
  • 461
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Mitochondrial toxicity of nrti antiviral drugs: an integrated cellular perspective
Highly active antiretroviral therapy (HAART) regimes based on nucleoside reverse transcriptase inhibitors (NRTIs) have revolutionized the treatment of AIDS in recent years. Although HAART canExpand
  • 422
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Requirement for Superoxide in Excitotoxic Cell Death
We tested the pathogenic role of O2-) radicals in excitotoxic injury. Inactivation of the TCA cycle enzyme, aconitase, was used as a marker of intracellular O2- levels, and a porphyrin SOD mimeticExpand
  • 427
  • 19
A mechanism of paraquat toxicity involving nitric oxide synthase.
Paraquat (PQ) is a well described pneumotoxicant that produces toxicity by redox cycling with cellular diaphorases, thereby elevating intracellular levels of superoxide (O-(2)). NO synthase (NOS) hasExpand
  • 196
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On topological quotient maps preserved by pullbacks or products
We are concerned with the category of topological spaces and continuous maps. A surjection f : X → Y in this category is called a quotient map if G is open in Y whenever f −1 G is open in X . OurExpand
  • 96
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A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase
Reactive oxygen species (ROS) have been implicated in a wide range of degenerative processes including amyotrophic lateral sclerosis, ischemic heart disease, Alzheimer disease, Parkinson disease andExpand
  • 478
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Metalloporphyrin class of therapeutic catalytic antioxidants.
  • M. Patel, B. Day
  • Medicine, Chemistry
  • Trends in pharmacological sciences
  • 1 September 1999
Metalloporphyrins have emerged as a novel class of catalytic antioxidants that scavenge a wide range of reactive oxygen species (ROS) such as superoxide, peroxide, peroxynitrite and lipid peroxylExpand
  • 228
  • 10
Catalase and glutathione peroxidase mimics.
  • B. Day
  • Medicine, Chemistry
  • Biochemical pharmacology
  • 1 February 2009
Overproduction of the reactive oxygen species (ROS) superoxide (O(2)(-)) and hydrogen peroxide (H(2)O(2)) are increasingly implicated in human disease and aging. ROS are also being explored asExpand
  • 168
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Basal and Stimulated Protein S-Nitrosylation in Multiple Cell Types and Tissues*
There is substantial evidence that proteinS-nitrosylation provides a significant route through which nitric oxide (NO)-derived bioactivity is conveyed. However, most examples of S-nitrosylation haveExpand
  • 280
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Manganic porphyrins possess catalase activity and protect endothelial cells against hydrogen peroxide-mediated injury.
Manganic porphyrins are redox active metal complexes that have been employed as superoxide dismutase mimics. We tested whether these metalloporphyrins could also dismute hydrogen peroxide (H2O2) andExpand
  • 282
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