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NOS2 gene

Known as: NOS2, NOS2A, NITRIC OXIDE SYNTHASE, INDUCIBLE 
This gene is involved in vasodilation and regulation of the bactericidal/tumoricidal actions of macrophages.
National Institutes of Health

Related topics

Related topics

6 relations
Intercellular Communication ProcessNOS2A protein, humanNitric Oxide SynthaseNitric Oxide Synthase Type II
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NOS2 wt Allele

Papers overview

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Highly Cited
2012
Highly Cited
2012
High Fat Diet-Induced Gut Microbiota Exacerbates Inflammation and Obesity in Mice via the TLR4 Signaling Pathway
Background & Aims While it is widely accepted that obesity is associated with low-grade systemic inflammation, the molecular… Expand
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Highly Cited
2012
Highly Cited
2012
Inflammation switches the differentiation program of Ly6Chi monocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon
Dendritic cells (DCs) and macrophages (MPs) are important for immunological homeostasis in the colon. We found that F4/80(hi… Expand
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Highly Cited
2011
Highly Cited
2011
Interleukin-10 reduces the pathology of mdx muscular dystrophy by deactivating M1 macrophages and modulating macrophage phenotype.
M1 macrophages play a major role in worsening muscle injury in the mdx mouse model of Duchenne muscular dystrophy. However, mdx… Expand
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Review
2010
Review
2010
The role of TLRs, NLRs, and RLRs in mucosal innate immunity and homeostasis
The mucosal surfaces of the gastrointestinal tract are continually exposed to an enormous antigenic load of microbial and dietary… Expand
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Highly Cited
2008
Highly Cited
2008
High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice.
Recent findings suggest that hypercholesterolemia may contribute to the onset of Alzheimer's disease-like dementia but the… Expand
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Highly Cited
2006
Highly Cited
2006
Inhibition of pro-inflammatory markers in primary bone marrow-derived mouse macrophages by naturally occurring flavonoids: analysis of the structure-activity relationship.
Flavonoids possess several biological/pharmacological activities including anticancer, antimicrobial, antiviral, anti… Expand
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Highly Cited
2003
Highly Cited
2003
TNF/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection.
Dendritic cells (DCs) present microbial antigens to T cells and provide inflammatory signals that modulate T cell differentiation… Expand
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Highly Cited
2002
Highly Cited
2002
Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway…
In an effort to better understand the phenomenon of lipotoxicity in human beta-cells, we evaluated the effects of 48-h preculture… Expand
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Highly Cited
2002
Highly Cited
2002
Evaluation of natural products on inhibition of inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) in cultured mouse macrophage cells.
The inhibitors of prostaglandin biosynthesis and nitric oxide production have been considered as potential anti-inflammatory and… Expand
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Highly Cited
1996
Highly Cited
1996
Reactivation of latent leishmaniasis by inhibition of inducible nitric oxide synthase
Nitric oxide (NO) synthase (iNOS) is required for the resolution of acute cutaneous leishmaniasis in resistant C57BL/6 mice. As… Expand
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