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NOS2 gene

Known as: NOS2, NOS2A, NITRIC OXIDE SYNTHASE, INDUCIBLE 
This gene is involved in vasodilation and regulation of the bactericidal/tumoricidal actions of macrophages.
National Institutes of Health

Related topics

Related topics

6 relations
Intercellular Communication ProcessNOS2A protein, humanNitric Oxide SynthaseNitric Oxide Synthase Type II

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NOS2 wt Allele

Papers overview

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Highly Cited
2012
Highly Cited
2012
1,25-Dihydroxyvitamin D3 curtails the inflammatory and T cell stimulatory capacity of macrophages through an IL-10-dependent mechanism.
Highly Cited
2009
Highly Cited
2009
iNOS-Producing Inflammatory Dendritic Cells Constitute the Major Infected Cell Type during the Chronic Leishmania major Infection Phase of C57BL/6 Resistant Mice
Leishmania major parasites reside and multiply in late endosomal compartments of host phagocytic cells. Immune control of… 
Highly Cited
2008
Highly Cited
2008
Progression of Amyloid Pathology to Alzheimer's Disease Pathology in an Amyloid Precursor Protein Transgenic Mouse Model by Removal of Nitric Oxide Synthase 2
Alzheimer's disease (AD) is characterized by three primary pathologies in the brain: amyloid plaques, neurofibrillary tangles… 
Highly Cited
2004
Highly Cited
2004
Evidence for a cluster of genes on chromosome 17q11–q21 controlling susceptibility to tuberculosis and leprosy in Brazilians
The region of conserved synteny on mouse chromosome 11/human 17q11–q21 is known to carry a susceptibility gene(s) for… 
Highly Cited
2003
Highly Cited
2003
Improvement of the mitochondrial antioxidant defense status prevents cytokine-induced nuclear factor-kappaB activation in insulin-producing cells.
Proinflammatory cytokines (interleukin-1beta [IL-1beta], tumor necrosis factor-alpha [TNF-alpha], and gamma-interferon [IFN-gamma… 
Highly Cited
2003
Highly Cited
2003
Bacterial Lipopolysaccharide Signaling Through Toll-Like Receptor 4 Suppresses Asthma-Like Responses Via Nitric Oxide Synthase 2 Activity1
Asthma results from an intrapulmonary allergen-driven Th2 response and is characterized by intermittent airway obstruction… 
Highly Cited
1996
Highly Cited
1996
Reactivation of latent leishmaniasis by inhibition of inducible nitric oxide synthase
Nitric oxide (NO) synthase (iNOS) is required for the resolution of acute cutaneous leishmaniasis in resistant C57BL/6 mice. As… 
Highly Cited
1995
Highly Cited
1995
Marked Induction of Calcium-Independent Nitric Oxide Synthase Activity after Focal Cerebral Ischemia
We studied the effect of focal cerebral ischemia on inducible (iNOS) and constitutive (cNOS) nitric oxide synthase enzymatic… 
Highly Cited
1994
Highly Cited
1994
Attenuation of the induction of nitric oxide synthase by endogenous glucocorticoids accounts for endotoxin tolerance in vivo.
An enhanced formation of nitric oxide (NO) due to induction of a calcium-independent (inducible) NO synthase (iNOS) contributes… 
Highly Cited
1993
Highly Cited
1993
Acute cerebral toxoplasmosis is induced by in vivo neutralization of TNF-alpha and correlates with the down-regulated expression of inducible nitric oxide synthase and other markers of macrophage…
C57BL/6 mice infected with the ME-49 strain of Toxoplasma gondii develop a progressive encephalitis culminating in 100% mortality… 
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