A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite.
- K. Miranda, M. Espey, D. Wink
- Chemistry, BiologyNitric oxide
- 1 February 2001
A method for simultaneous evaluation of nitrate and nitrite concentrations in a microtiter plate format is developed and S-Nitrosothiols and L-arginine derivatives were found to be potential interfering agents.
Chemical biology of nitric oxide: Insights into regulatory, cytotoxic, and cytoprotective mechanisms of nitric oxide.
- D. Wink, J. Mitchell
- Biology, ChemistryFree Radical Biology & Medicine
- 1 September 1998
Methods for detection of reactive metabolites of oxygen and nitrogen: in vitro and in vivo considerations.
- M. Tarpey, D. Wink, M. Grisham
- Biology, ChemistryAmerican Journal of Physiology. Regulatory…
- 1 March 2004
This review describes approaches to the direct and indirect measurement of different reactive metabolites of oxygen and nitrogen and particular attention to a method's applicability for in vivo determinations will be addressed.
The chemical biology of nitric oxide: implications in cellular signaling.
- D. Thomas, L. Ridnour, D. Wink
- Biology, ChemistryFree Radical Biology & Medicine
- 1 July 2008
Complexes of .NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects.
- C. Maragos, D. Morley, L. Keefer
- Chemistry, BiologyJournal of Medicinal Chemistry
- 1 November 1991
Vasorelaxant potency (expressed as 1/EC50) was strongly correlated with the quantity of .NO calculated from the physicochemical data to be released in the interval required to achieve maximum relaxation at the EC50 doses, suggesting that such nucleophile/.NO adducts might generally be useful as vehicles for the nonenzymatic generation of nitric oxide, in predictable amounts and at predictable rates, for biological purposes.
New nitric oxide-releasing zwitterions derived from polyamines
The reaction of nitric oxide (NO) with polyamines has been studied, resulting in the discovery of a new type of NO-releasing compound having the structure RN[N(O)NO][sup [minus]](CH[sub 2])[sub…
"NONOates" (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: convenient nitric oxide dosage forms.
- L. Keefer, R. Nims, K. M. Davies, D. Wink
- BiologyMethods in Enzymology
- 1996
DNA deaminating ability and genotoxicity of nitric oxide and its progenitors.
- D. Wink, K. Kasprzak, J. S. Allen
- BiologyScience
- 15 November 1991
Nitric oxide (NO), a multifaceted bioregulatory agent and an environmental pollutant, can also cause genomic alterations that may contribute to the incidence of deamination-related genetic disease and cancer.
Nitric oxide and redox mechanisms in the immune response
The chemistry of NO and ROS in the context of antipathogen activity and immune regulation is discussed and similarities and differences between murine and human production of these intermediates are discussed.
The multifaceted roles of nitric oxide in cancer.
- D. Wink, Y. Vodovotz, J. Laval, F. Laval, M. Dewhirst, J. Mitchell
- Chemistry, BiologyCarcinogenesis
- 1 May 1998
How the chemistry of NO may impact the initiation and progression stages of cancer is discussed.
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