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Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and…
Association between body-mass index and risk of death in more than 1 million Asians.
Underweight was associated with a substantially increased risk of death in all Asian populations, however, the excess risk of died was seen among East Asians but not among Indians and Bangladeshis.
Association analysis identifies 65 new breast cancer risk loci
A genome-wide association study of breast cancer in 122,977 cases and 105,974 controls of European ancestry and 14,068 cases and 13,104 controls of East Asian ancestry finds that heritability of Breast cancer due to all single-nucleotide polymorphisms in regulatory features was 2–5-fold enriched relative to the genome- wide average.
Decreased Serum Free Testosterone in Workers Exposed to High Levels of Di-n-butyl Phthalate (DBP) and Di-2-ethylhexyl Phthalate (DEHP): A Cross-Sectional Study in China
A modest and significant reduction of serum fT is observed in workers with higher levels of urinary MBP and MEHP compared with unexposed workers, and regression analyses revealed that fT decreases significantly with increasing total phthalate ester score.
Diabetes mellitus and the risk of cancer: results from a large-scale population-based cohort study in Japan.
- M. Inoue, M. Iwasaki, T. Otani, S. Sasazuki, M. Noda, S. Tsugane
- MedicineArchives of internal medicine
- 25 September 2006
Patients with DM drawn from the general Japanese population may be at increased risk of total cancer and of cancer in specific sites.
Intake of Fish and n3 Fatty Acids and Risk of Coronary Heart Disease Among Japanese: The Japan Public Health Center-Based (JPHC) Study Cohort I
Compared with a modest fish intake of once a week or ≈20 g/d, a higher intake was associated with substantially reduced risk of coronary heart disease, primarily nonfatal cardiac events, among middle-aged persons.
Impact of metabolic factors on subsequent cancer risk: results from a large-scale population-based cohort study in Japan
- M. Inoue, M. Noda, S. Tsugane
- Medicine, BiologyEuropean journal of cancer prevention : the…
- 1 June 2009
In both sexes, the presence of metabolic factors in the aggregate did not predict subsequent occurrence of cancer as a whole, although the association between specific components and specific cancers suggests an etiologic link between them.
Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases
A large-scale genome-wide association study in a Japanese population provides insights into the etiology of complex diseases and highlights the importance of performing GWAS in non-European populations.
Single measurement of serum phospholipid fatty acid as a biomarker of specific fatty acid intake in middle-aged Japanese men
- M. Kobayashi, S. Sasaki, T. Kawabata, K. Hasegawa, M. Akabane, S. Tsugane
- MedicineEuropean Journal of Clinical Nutrition
- 1 August 2001
Assessment of serum phospholipid fatty acid levels in Japanese suggests that in populations with a high and stable over time intake of n-3 PUFA of marine origin, a single measurement of serumospholipids reflects the ranking of habitual intake of marineorigin n- 3 PUFA.
Folate, Vitamin B6, Vitamin B12, and Vitamin B2 Intake, Genetic Polymorphisms of Related Enzymes, and Risk of Colorectal Cancer in a Hospital-Based Case-Control Study in Japan
The study did not support the existing hypothesis of gene-nutrient interaction in colorectal carcinogenesis and the association of nutrient intake involved in the one-carbon pathway of folate for DNA methylation and DNA synthesis and the related enzyme genetic polymorphisms with coloreCTal cancer.