NOD2 gene

Known as: CD, NLRC2, nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 2 
This gene is involved in immune responses and cell death.
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
Nucleotide-binding oligomerization domain–containing-2 (NOD2) acts as a bacterial sensor in dendritic cells (DCs), but it is not… (More)
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Highly Cited
2010
Highly Cited
2010
Autophagy is emerging as a crucial defense mechanism against bacteria, but the host intracellular sensors responsible for… (More)
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Review
2006
Review
2006
The NOD (nucleotide-binding oligomerization domain) proteins NOD1 and NOD2 have important roles in innate immunity as sensors of… (More)
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Highly Cited
2004
Highly Cited
2004
The mechanism by which mutations in CARD15, which encodes nucleotide-binding oligomerization domain 2 (NOD2), cause Crohn disease… (More)
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Highly Cited
2004
Highly Cited
2004
BACKGROUND Mutations in NOD2, a putative intracellular receptor for bacterial peptidoglycans, are associated with a subset of… (More)
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Highly Cited
2003
Highly Cited
2003
NOD2, a protein associated with susceptibility to Crohn's disease, confers responsiveness to bacterial preparations of… (More)
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Highly Cited
2002
Highly Cited
2002
CARD15/NOD2 encodes a protein involved in bacterial recognition by monocytes. Mutations in CARD15 have recently been found in… (More)
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Highly Cited
2001
Highly Cited
2001
Crohn's disease is a chronic inflammatory disorder of the gastrointestinal tract, which is thought to result from the effect of… (More)
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Highly Cited
2001
Highly Cited
2001
Crohn's disease and ulcerative colitis, the two main types of chronic inflammatory bowel disease, are multifactorial conditions… (More)
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Highly Cited
2001
Highly Cited
2001
Apaf-1 and Nod1 are members of a protein family, each of which contains a caspase recruitment domain (CARD) linked to a… (More)
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