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NOD2 gene

Known as: CD, NLRC2, nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 2 
This gene is involved in immune responses and cell death.
National Institutes of Health

Related topics

Related topics

6 relations
ApoptosisCaspase-Dependent ApoptosisNOD2 wt AlleleNucleotide-Binding Oligomerization Domain-Containing Protein 2

Papers overview

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Highly Cited
2009
Highly Cited
2009
Perforated Duodenal Diverticulitis Caused by Retained Common Bile Duct Stone in the Diverticulum
OBJECTIVES:Recently, genome-wide association analyses have identified single nucleotide polymorphisms in the IRGM gene (rs1000113… 
Review
2008
Review
2008
CARD15 and IL23R influences Crohn's disease susceptibility but not disease phenotype in a Brazilian population
Background: Although many genetic variants are identified in association with Crohn's disease (CD), CARD15, IL23R, and ATG16L1… 
Highly Cited
2008
Highly Cited
2008
Nod2 Mediates Susceptibility to Yersinia pseudotuberculosis in Mice
Nucleotide oligomerisation domain 2 (NOD2) is a component of the innate immunity known to be involved in the homeostasis of Peyer… 
Highly Cited
2008
Highly Cited
2008
Novel NOD2 haplotype strengthens the association between TLR4 Asp299gly and Crohn's disease in an Australian population
Background: The first major Crohn's disease (CD) susceptibility gene, NOD2, implicates the innate intestinal immune system and… 
Highly Cited
2006
Highly Cited
2006
Extreme heterogeneity in CARD15 and DLG5 Crohn disease-associated polymorphisms between German and Norwegian populations
The first gene associated with Crohn disease (CD) has been identified as CARD15 (16q12). Three variants, R702W, G908R and… 
Highly Cited
2006
Highly Cited
2006
Relationship between CARD15, SLC22A4/5, and DLG5 polymorphisms and early-onset inflammatory bowel diseases: an Italian multicentric study.
BACKGROUND Inflammatory bowel disease (IBD) has been associated with several polymorphisms in genes likely involved in innate… 
Highly Cited
2005
Highly Cited
2005
NOD2 3020insC mutation and the pathogenesis of Crohn's disease: impaired IL-1beta production points to a loss-of-function phenotype.
BACKGROUND Mutations of the NOD2 gene increase the susceptibility of humans to Crohn's disease. NOD2 is a cytoplasmic receptor… 
Highly Cited
2004
Highly Cited
2004
Transmission of CARD15 (NOD2) Variants Within Families of Patients with Inflammatory Bowel Disease
OBJECTIVES:Three single nucleotide polymorphisms (SNPs) in CARD15 have been independently associated with Crohn's disease (CD… 
Highly Cited
2003
Highly Cited
2003
CARD15 Genotype and Phenotype Analysis in 55 Pediatric Patients With Crohn Disease From Saxony, Germany
Objectives Crohn disease is a chronic inflammatory bowel disorder that is caused by environmental and genetic factors. Mutations… 
Highly Cited
2002
Highly Cited
2002
Role of NOD2 variants in spondylarthritis.
OBJECTIVE To investigate the role of the gene NOD2 in susceptibility to, and clinical manifestations of, ankylosing spondylitis… 
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