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Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy
BACKGROUND Invasive fungal diseases are important causes of morbidity and mortality. Clarity and uniformity in defining these infections are important factors in improving the quality of clinicalExpand
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Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America.
Guidelines for the management of patients with invasive candidiasis and mucosal candidiasis were prepared by an Expert Panel of the Infectious Diseases Society of America. These updated guidelinesExpand
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An integrated model of the recognition of Candida albicans by the innate immune system
The innate immune response was once considered to be a limited set of responses that aimed to contain an infection by primitive 'ingest and kill' mechanisms, giving the host time to mount a specificExpand
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ESCMID* guideline for the diagnosis and management of Candida diseases 2012: non-neutropenic adult patients.
This part of the EFISG guidelines focuses on non-neutropenic adult patients. Only a few of the numerous recommendations can be summarized in the abstract. Prophylactic usage of fluconazole isExpand
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Invasive Candidiasis.
Invasive candidiasis is the most common fungal disease among hospitalized patients in the developed world. Invasive candidiasis comprises both candidemia and deep-seated tissue candidiasis.Expand
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Toll-like receptor 2 controls expansion and function of regulatory T cells.
Tregs play a central role in the suppression of immune reactions and prevention of autoimmune responses harmful to the host. During acute infection, however, Tregs might hinder effector T cellExpand
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Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors.
The fungal pathogen Candida albicans has a multilayered cell wall composed of an outer layer of proteins glycosylated with N- or O-linked mannosyl residues and an inner skeletal layer of beta-glucansExpand
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Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages.
The processing of pro-interleukin-1beta depends on activation of caspase-1. Controversy has arisen whether Toll-like receptor (TLR) ligands alone can activate caspase-1 for release ofExpand
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Candida albicans infection affords protection against reinfection via functional reprogramming of monocytes.
Immunological memory in vertebrates is often exclusively attributed to T and B cell function. Recently it was proposed that the enhanced and sustained innate immune responses following initialExpand
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STAT1 mutations in autosomal dominant chronic mucocutaneous candidiasis.
BACKGROUND Chronic mucocutaneous candidiasis (CMC) is characterized by susceptibility to candida infection of skin, nails, and mucous membranes. Patients with recessive CMC and autoimmunity haveExpand
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