NM-441

Known as: NM 441, NM441 
 
National Institutes of Health

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prulifloxacin

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1998
1998
Paraoxonase has a major role in the hydrolysis of prulifloxacin (NM441), a prodrug of a new antibacterial agent.
NM441 is a prodrug of the new quinolone carboxylic acid antibacterial agent NM394. A rat serum enzyme (NM441-hydrolase) that… Expand
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1997
1997
Pharmacokinetics of prulifloxacin. 1st communication: absorption, distribution and excretion in rats, dogs and monkeys after a single administration.
The pharmacokinetics of prulifloxacin ((+/-)-6-fluoro-1-methyl-7-[4-(5-methyl-2-oxo-1,3-dioxolen-4-yl) methyl-1-piperazinyl]-4… Expand
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1997
1997
Pharmacokinetics of prulifloxacin. 2nd communication: pharmacokinetics and effect on hepatic drug-metabolizing enzyme activities after repeated administration and transfer into fetus and milk after a…
Prulifloxacin ((+/-)-6-fluoro-1-methyl-7-[4-(5-methyl-2-oxo-1,3-dioxolen-4-yl) methyl-1-piperazinyl]-4-oxo-4H-[1,3]thiazeto[3,2-a… Expand
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1997
1997
Pharmacokinetics of prulifloxacin. 3rd communication: metabolism in rats, dogs and monkeys.
The metabolism of the new quinolone antibacterial prodrug prulifloxacin ((+/-)-6-fluoro-1-methyl-7-[4-(5-methyl-2-oxo-1, 3… Expand
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1997
1997
In vivo antibacterial activity of a prodrug of NM394, a thiazetoquinoline carboxylic acid derivative.
NM394 (6-fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-[1,3]-thiazeto [3,2-a]quinoline-3-carboxylic acid) has potent, broad-spectrum… Expand
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1995
1995
Penetration of NM441, a New Quinolone, into Human Bile and Gallbladder Tissue
NM441, 6-fluoro-1-methyl-7-[4-(5-methyl2-oxo-1,3,-dioxolen-4-yl) methyl-1-piperazinyl]4-oxo-4H- [1,3 ]thiazeto[3,2-a]quinoline3… Expand
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1994
1994
Pharmacokinetics and safety of NM441, a new quinolone, in healthy male volunteers.
The safety and pharmacokinetics of NM441, a prodrug of a new thiazeto-quinoline carboxylic acid derivative, NM394, were evaluated… Expand
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1993
1993
Antibacterial activity of NM394, the active form of prodrug NM441, a new quinolone.
The in vitro antibacterial activity of NM394 was compared with those of other new quinolones. NM394 showed potent and broad… Expand
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1992
1992
Studies on pyridonecarboxylic acids. 1. Synthesis and antibacterial evaluation of 7-substituted-6-halo-4-oxo-4H-[1,3]thiazeto[3,2-a]quinoline-3- carboxylic acids.
A series of [1,3]thiazeto[3,2-a]quinoline-3-carboxylic acids and their esters were prepared and evaluated for antibacterial… Expand
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1991
1991
In vivo evaluation of NM441, a new thiazeto-quinoline derivative.
NM441 is a lipophilic prodrug of a new thiazeto-quinoline carboxylic acid derivative NM394, and when it is administered orally it… Expand
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