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NM-441
Known as:
NM 441
, NM441
National Institutes of Health
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Related topics
Related topics
1 relation
Broader (1)
prulifloxacin
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1998
Highly Cited
1998
Paraoxonase has a major role in the hydrolysis of prulifloxacin (NM441), a prodrug of a new antibacterial agent.
K. Tougou
,
A. Nakamura
,
S. Watanabe
,
Y. Okuyama
,
A. Morino
Drug metabolism and disposition: the biological…
1998
Corpus ID: 11352755
NM441 is a prodrug of the new quinolone carboxylic acid antibacterial agent NM394. A rat serum enzyme (NM441-hydrolase) that…
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1998
1998
Pharmacokinetic Interactions between Theophylline and Prulifloxacin in Healthy Volunteers
C. Fattore
,
G. Cipolla
,
+6 authors
E. Perucca
1998
Corpus ID: 71905117
AbstractObjective: To determine the potential influence of prulifloxacin (AF3012, NM441), a new antibacterial fluoroquinolone, on…
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1997
1997
Pharmacokinetics of prulifloxacin. 1st communication: absorption, distribution and excretion in rats, dogs and monkeys after a single administration.
Y. Okuyama
,
K. Momota
,
A. Morino
Arzneimittel-Forschung
1997
Corpus ID: 12689778
The pharmacokinetics of prulifloxacin ((+/-)-6-fluoro-1-methyl-7-[4-(5-methyl-2-oxo-1,3-dioxolen-4-yl) methyl-1-piperazinyl]-4…
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1997
1997
Pharmacokinetics of prulifloxacin. 2nd communication: pharmacokinetics and effect on hepatic drug-metabolizing enzyme activities after repeated administration and transfer into fetus and milk after a…
Y. Okuyama
,
K. Momota
,
A. Morino
Arzneimittel-Forschung
1997
Corpus ID: 40497105
Prulifloxacin ((+/-)-6-fluoro-1-methyl-7-[4-(5-methyl-2-oxo-1,3-dioxolen-4-yl) methyl-1-piperazinyl]-4-oxo-4H-[1,3]thiazeto[3,2-a…
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1997
1997
In vivo Antibacterial Activity of a Prodrug of NM394, a Thiazetoquinoline Carboxylic Acid Derivative
M. Ozaki
,
Y. Tomii
,
+4 authors
T. Nishino
Chemotherapy
1997
Corpus ID: 46816749
NM394 (6-fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid) has potent, broad-spectrum…
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1997
1997
Pharmacokinetics of prulifloxacin. 3rd communication: metabolism in rats, dogs and monkeys.
Y. Okuyama
,
A. Morino
Arzneimittel-Forschung
1997
Corpus ID: 23611689
The metabolism of the new quinolone antibacterial prodrug prulifloxacin ((+/-)-6-fluoro-1-methyl-7-[4-(5-methyl-2-oxo-1, 3…
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1994
1994
Pharmacokinetics and Safety of NM441, a New Quinolone, in Healthy Male Volunteers
M. Nakashima
,
T. Uematsu
,
+4 authors
Y. Takebe
Journal of clinical pharmacology
1994
Corpus ID: 20454608
The safety and pharmacokinetics of NM441, a prodrug of a new thiazeto‐quinoline carboxylic acid derivative, NM394, were evaluated…
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1993
1993
Antibacterial activity of NM394, the active form of prodrug NM441, a new quinolone
T. Yoshida
,
S. Mitsuhashi
Antimicrobial Agents and Chemotherapy
1993
Corpus ID: 23238555
The in vitro antibacterial activity of NM394 was compared with those of other new quinolones. NM394 showed potent and broad…
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1992
1992
Studies on pyridonecarboxylic acids. 1. Synthesis and antibacterial evaluation of 7-substituted-6-halo-4-oxo-4H-[1,3]thiazeto[3,2-a]quinoline-3- carboxylic acids.
J. Segawa
,
M. Kitano
,
+6 authors
M. Kise
Journal of medicinal chemistry
1992
Corpus ID: 7748375
A series of [1,3]thiazeto[3,2-a]quinoline-3-carboxylic acids and their esters were prepared and evaluated for antibacterial…
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1991
1991
In vivo evaluation of NM441, a new thiazeto-quinoline derivative
M. Ozaki
,
M. Matsuda
,
+7 authors
T. Nishino
Antimicrobial Agents and Chemotherapy
1991
Corpus ID: 46207676
NM441 is a lipophilic prodrug of a new thiazeto-quinoline carboxylic acid derivative NM394, and when it is administered orally it…
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