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NM-441

Known as: NM 441, NM441 
National Institutes of Health

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1 relation

Broader (1)

prulifloxacin

Papers overview

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Highly Cited
1998
Highly Cited
1998
Paraoxonase has a major role in the hydrolysis of prulifloxacin (NM441), a prodrug of a new antibacterial agent.
NM441 is a prodrug of the new quinolone carboxylic acid antibacterial agent NM394. A rat serum enzyme (NM441-hydrolase) that… 
1998
1998
Pharmacokinetic Interactions between Theophylline and Prulifloxacin in Healthy Volunteers
AbstractObjective: To determine the potential influence of prulifloxacin (AF3012, NM441), a new antibacterial fluoroquinolone, on… 
1997
1997
Pharmacokinetics of prulifloxacin. 1st communication: absorption, distribution and excretion in rats, dogs and monkeys after a single administration.
The pharmacokinetics of prulifloxacin ((+/-)-6-fluoro-1-methyl-7-[4-(5-methyl-2-oxo-1,3-dioxolen-4-yl) methyl-1-piperazinyl]-4… 
1997
1997
Pharmacokinetics of prulifloxacin. 2nd communication: pharmacokinetics and effect on hepatic drug-metabolizing enzyme activities after repeated administration and transfer into fetus and milk after a…
Prulifloxacin ((+/-)-6-fluoro-1-methyl-7-[4-(5-methyl-2-oxo-1,3-dioxolen-4-yl) methyl-1-piperazinyl]-4-oxo-4H-[1,3]thiazeto[3,2-a… 
1997
1997
Pharmacokinetics of prulifloxacin. 3rd communication: metabolism in rats, dogs and monkeys.
The metabolism of the new quinolone antibacterial prodrug prulifloxacin ((+/-)-6-fluoro-1-methyl-7-[4-(5-methyl-2-oxo-1, 3… 
1997
1997
In vivo Antibacterial Activity of a Prodrug of NM394, a Thiazetoquinoline Carboxylic Acid Derivative
NM394 (6-fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid) has potent, broad-spectrum… 
1996
1996
Therapeutic effect of the quinolone prodrug prulifloxacin against experimental urinary tract infections in mice.
The in vitro antibacterial activity of prulifloxacin (CAS 123447-62-1, NM441), a new quinoline prodrug, against clinical isolates… 
1996
1996
[A 13-week oral toxicity study of prulifloxacin (NM441) in dogs followed by a 5-week recovery test].
A repeated dose toxicity study of prulifloxacin, a new antibacterial agent, was conducted in beagle dogs. Male and female dogs… 
1993
1993
Antibacterial activity of NM394, the active form of prodrug NM441, a new quinolone
The in vitro antibacterial activity of NM394 was compared with those of other new quinolones. NM394 showed potent and broad… 
1991
1991
In vivo evaluation of NM441, a new thiazeto-quinoline derivative
NM441 is a lipophilic prodrug of a new thiazeto-quinoline carboxylic acid derivative NM394, and when it is administered orally it… 
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