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NM-441

Known as: NM 441, NM441 
 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

prulifloxacin

Papers overview

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2012
2012
NM441: Penetration into Gynaecological Tissues and In Vitro Activity against Clinical Isolates from Obstetric and Gynaecological Patients
Since the development of norfloxacin, many fluoroquinolones with broad spectrum antibacterial activity, such as ciprofloxacin or… Expand
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Highly Cited
1998
Highly Cited
1998
Paraoxonase has a major role in the hydrolysis of prulifloxacin (NM441), a prodrug of a new antibacterial agent.
NM441 is a prodrug of the new quinolone carboxylic acid antibacterial agent NM394. A rat serum enzyme (NM441-hydrolase) that… Expand
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1998
1998
Pharmacokinetic Interactions between Theophylline and Prulifloxacin in Healthy Volunteers
AbstractObjective: To determine the potential influence of prulifloxacin (AF3012, NM441), a new antibacterial fluoroquinolone, on… Expand
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1997
1997
Pharmacokinetics of prulifloxacin. 1st communication: absorption, distribution and excretion in rats, dogs and monkeys after a single administration.
The pharmacokinetics of prulifloxacin ((+/-)-6-fluoro-1-methyl-7-[4-(5-methyl-2-oxo-1,3-dioxolen-4-yl) methyl-1-piperazinyl]-4… Expand
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1997
1997
Pharmacokinetics of prulifloxacin. 2nd communication: pharmacokinetics and effect on hepatic drug-metabolizing enzyme activities after repeated administration and transfer into fetus and milk after a…
Prulifloxacin ((+/-)-6-fluoro-1-methyl-7-[4-(5-methyl-2-oxo-1,3-dioxolen-4-yl) methyl-1-piperazinyl]-4-oxo-4H-[1,3]thiazeto[3,2-a… Expand
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1997
1997
Pharmacokinetics of prulifloxacin. 3rd communication: metabolism in rats, dogs and monkeys.
The metabolism of the new quinolone antibacterial prodrug prulifloxacin ((+/-)-6-fluoro-1-methyl-7-[4-(5-methyl-2-oxo-1, 3… Expand
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1994
1994
Pharmacokinetics and Safety of NM441, a New Quinolone, in Healthy Male Volunteers
The safety and pharmacokinetics of NM441, a prodrug of a new thiazeto‐quinoline carboxylic acid derivative, NM394, were evaluated… Expand
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1993
1993
Antibacterial activity of NM394, the active form of prodrug NM441, a new quinolone.
The in vitro antibacterial activity of NM394 was compared with those of other new quinolones. NM394 showed potent and broad… Expand
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1992
1992
Studies on pyridonecarboxylic acids. 1. Synthesis and antibacterial evaluation of 7-substituted-6-halo-4-oxo-4H-[1,3]thiazeto[3,2-a]quinoline-3- carboxylic acids.
A series of [1,3]thiazeto[3,2-a]quinoline-3-carboxylic acids and their esters were prepared and evaluated for antibacterial… Expand
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1991
1991
In vivo evaluation of NM441, a new thiazeto-quinoline derivative.
NM441 is a lipophilic prodrug of a new thiazeto-quinoline carboxylic acid derivative NM394, and when it is administered orally it… Expand
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