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Substrate Specificities of MexAB-OprM, MexCD-OprJ, and MexXY-OprM Efflux Pumps in Pseudomonas aeruginosa
TLDR
To find the exact substrate specificities of three species of tripartite efflux systems of Pseudomonas aeruginosa, MexAB-OprM, MexCD- oprJ, and MexXY-OPRM, a series of isogenic mutants were constructed, each constitutively overproduced one of the three efflux system and lacked the other two. Expand
Emergence of a unique O3:K6 clone of Vibrio parahaemolyticus in Calcutta, India, and isolation of strains from the same clonal group from Southeast Asian travelers arriving in Japan.
TLDR
The results suggest that this unique O3:K6 clone may have become prevalent not only in Calcutta but also in Southeast Asian countries very recently. Expand
Crystal structures of bovine milk xanthine dehydrogenase and xanthine oxidase: structure-based mechanism of conversion.
TLDR
The crystal structure of the dimeric bovine milk XDH is presented and the major changes that occur on the proteolytic transformation of XDH to the XO form are described, reflecting the switch of substrate specificity observed for the two forms of this enzyme. Expand
Overexpression of the mexC–mexD–oprJ efflux operon in nfxB‐type multidrug‐resistant strains of Pseudomonas aeruginosa
TLDR
Data indicate that the multidrug resistance of nfxB strains is due to overexpression of an efflux operon, mexC–mexD–oprJ, encoding components of a second efflux pump in P. aeruginosa. Expand
Contribution of the MexX-MexY-OprM Efflux System to Intrinsic Resistance in Pseudomonas aeruginosa
TLDR
The results suggest that MexXY induced by these agents is functionally associated with spontaneously expressed OprM and contributes to the intrinsic resistance to these agents. Expand
Characterization of the MexC-MexD-OprJ Multidrug Efflux System in ΔmexA-mexB-oprM Mutants of Pseudomonas aeruginosa
TLDR
Characterization of mutants lacking themexA-mexB-oprM region clearly indicated that the MexC-MexD-OprJ efflux system is involved in resistance to the ordinary cephems as well as fluoroquinolones and the fourth-generation cEPhems but not to carbenicillin and aztreonam. Expand
Crystal structure of a multifunctional 2-Cys peroxiredoxin heme-binding protein 23 kDa/proliferation-associated gene product.
TLDR
An unusual dimer structure of rat HBP23 in oxidized form revealed an unusual cysteine disulfide bond, involved in peroxidation catalysis by using thioredoxin as the source of reducing equivalents, which provides a clue to possible interaction surfaces for c-Abl and heme. Expand
Mammalian xanthine oxidoreductase – mechanism of transition from xanthine dehydrogenase to xanthine oxidase
TLDR
This review focuses on recent advances in the understanding of the mechanism of conversion from XDH to XO, suggesting that the conversion is not a simple artefact, but rather has a function in mammalian organisms. Expand
An Extremely Potent Inhibitor of Xanthine Oxidoreductase
TLDR
Although the inhibitor did not directly coordinate to the molybdenum ion, numerous hydrogen bonds as well as hydrophobic interactions with the protein matrix were observed, most of which are also used in substrate recognition. Expand
Mutation of human molybdenum cofactor sulfurase gene is responsible for classical xanthinuria type II.
TLDR
Results indicate that a functional defect of the HMCS gene is responsible for classical xanthinuria type II, and that HMCS protein functions to provide a sulfur atom for the molybdenum cofactor of XDH and AO. Expand
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