S. Mitsuhashi

Publications711
h-index49
Citations12,032
Highly Influential Citations180
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Transferable imipenem resistance in Pseudomonas aeruginosa
TLDR
An imipenem-resistant strain of Pseudomonas aeruginosa was isolated, which produced a beta-lactamase that hydrolyzed imIPenem and showed a broad substrate profile, hydrolyzing imipanem, oxyiminocephalosporins, 7-methoxycephalosporains, and penicillins.
Transferable resistance to cefotaxime, cefoxitin, cefamandole and cefuroxime in clinical isolates of Klebsiella pneumoniae and Serratia marcescens
TLDR
From results obtained in this study, it may be concluded that in some strains of nosocomialEnterobacteriaceae, resistance to newer cephalosporins could be transmissible and thus plasmid-located.
Mutations producing resistance to norfloxacin in Pseudomonas aeruginosa
TLDR
Two genetically distinct classes of norfloxacin-resistant Pseudomonas aeruginosa PAO4009 mutants were isolated spontaneously and it was suggested that the norfl oxacin resistance mechanism in the nfxB mutant might be an alteration in outer membrane permeability to norflxacin.
Differences in susceptibility to quinolones of outer membrane mutants of Salmonella typhimurium and Escherichia coli
TLDR
The mechanism of penetration of quinolones through the bacterial outer membrane was studied and indicated that the lipopolysaccharide layer might form a permeability barrier for hydrophobic quInolones such as nalidixic acid but not forhydrophilic quinolate such as norfloxacin and ciprofloxACin.
In vitro and in vivo antibacterial activities of CS-807, a new oral cephalosporin
TLDR
Systemic infections in mice caused by various pathogens, including beta-lactamase-producing strains, responded well to therapy with oral doses of CS-807, a new oral prodrug of R-3746, a cephalosporin derivative, with potent in vitro and in vivo antibacterial activity against both gram-positive and gram-negative bacteria.
Purification and properties of inducible penicillin beta-lactamase isolated from Pseudomonas maltophilia
TLDR
The purified penicillin beta-lactamase gave a single protein band on polyacrylamide gel electrophoresis, and showed a unique substrate profile, hydrolyzing N-formimidoyl thienamycin at a significant rate.
Frequency of heavy-metal resistance in bacteria from inpatients in Japan
TLDR
The frequency of drug and heavy-metal resistance in clinical isolates of E. coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and S. aureus was the same as, or higher than that of antibiotic resistance.
Isolation and characterization of norfloxacin-resistant mutants of Escherichia coli K-12
TLDR
Both NorB and NorC mutants had a lower rate of norfloxacin uptake, and it was found that the NorB mutant was altered in OmpF porin and that theNorC mutant was alteration in both Ompf porinand apparently in the lipopolysaccharide structure of the outer membrane.
Purification and properties of an inducible cephalosporinase from Pseudomonas maltophilia GN12873
TLDR
An inducible cephalosporinase was purified from Pseudomonas maltophilia GN12873, and showed a broad substrate profile, hydrolyzing cefazolin, cefsulodin, penicillin G, ceftizoxime, and ampicillin at a high rate.
Mechanisms of high-level resistance to quinolones in urinary tract isolates of Pseudomonas aeruginosa
TLDR
Findings suggest that GN17605 is a gyrA-nfxB double mutant and that strain GN17434-2 possesses double mutations in both nfxB and some unknown gene.
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