S. Mitsuhashi

Publications711
h-index47
Citations10,175
Highly Influential Citations141
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Transferable imipenem resistance in Pseudomonas aeruginosa.
We isolated an imipenem-resistant strain, GN17203, of Pseudomonas aeruginosa. The strain produced a beta-lactamase that hydrolyzed imipenem. The beta-lactamase was encoded by a 31-MDa plasmid,… Expand
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Mutations producing resistance to norfloxacin in Pseudomonas aeruginosa.
Two genetically distinct classes of norfloxacin-resistant Pseudomonas aeruginosa PAO4009 mutants were isolated spontaneously. Two norfloxacin resistance genes, nfxA and nfxB, were mapped hex-9001 and… Expand
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Differences in susceptibility to quinolones of outer membrane mutants of Salmonella typhimurium and Escherichia coli.
The mechanism of penetration of quinolones through the bacterial outer membrane was studied with lipopolysaccharide-deficient and porin-deficient mutants. The data indicated that the… Expand
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Purification and properties of an inducible cephalosporinase from Pseudomonas maltophilia GN12873.
An inducible cephalosporinase was purified from Pseudomonas maltophilia GN12873. The pI was 8.4, and the molecular weight was ca. 56,000 by gel filtration or 27,000 by sodium dodecyl… Expand
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Purification and properties of inducible penicillin beta-lactamase isolated from Pseudomonas maltophilia.
Two types of beta-lactamase were found in the cell-free extract from Pseudomonas maltophilia GN12873. One was an inducible penicillin beta-lactamase, and the other was an inducible cephalosporin… Expand
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Isolation and characterization of norfloxacin-resistant mutants of Escherichia coli K-12.
We isolated spontaneous mutants from Escherichia coli K-12 with low-level resistance to norfloxacin. These mutants were classified into the following three types on the basis of their properties: (i)… Expand
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Mechanisms of high-level resistance to quinolones in urinary tract isolates of Pseudomonas aeruginosa.
Twenty-eight strains of Pseudomonas aeruginosa with various degrees of norfloxacin resistance were isolated from patients with urinary tract infections. P. aeruginosa strains (norfloxacin MICs, 3.13… Expand
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Sequences of Homologous β-Lactamases from Clinical Isolates of Serratia marcescens with Different Substrate Specificities
ABSTRACT Genes for two group 1 β-lactamases, SRT-1 and SST-1, were sequenced. These β-lactamases were produced by clinical isolates ofSerratia marcescens, isolates GN16694 and GN19450, respectively.… Expand
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New Antipseudomonal Penicillin, PC-904: Affinity to Penicillin-Binding Proteins and Inhibition of the Enzyme Cross-Linking Peptidoglycan
The mechanism of action of a new antipseudomonal penicillin, PC-904, was studied with respect to its binding affinities to penicillin-binding proteins (PBPs) and its inhibitory activities on… Expand
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Cloning and expression in Enterobacteriaceae of the extended-spectrum beta-lactamase gene from a Pseudomonas aeruginosa plasmid.
An extended-spectrum beta-lactamase, the gene for which is located on plasmid pMS350 in Pseudomonas aeruginosa strains, hydrolyzes carbapenems and other extended-spectrum beta-lactam antibiotics. We… Expand
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