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- Publications
- Influence
Transferable imipenem resistance in Pseudomonas aeruginosa.
- M. Watanabe, S. Iyobe, M. Inoue, S. Mitsuhashi
- Medicine, Biology
- Antimicrobial Agents and Chemotherapy
- 1 January 1991
We isolated an imipenem-resistant strain, GN17203, of Pseudomonas aeruginosa. The strain produced a beta-lactamase that hydrolyzed imipenem. The beta-lactamase was encoded by a 31-MDa plasmid,… Expand
Mutations producing resistance to norfloxacin in Pseudomonas aeruginosa.
- K. Hirai, S. Suzue, T. Irikura, S. Iyobe, S. Mitsuhashi
- Medicine, Biology
- Antimicrobial Agents and Chemotherapy
- 1 April 1987
Two genetically distinct classes of norfloxacin-resistant Pseudomonas aeruginosa PAO4009 mutants were isolated spontaneously. Two norfloxacin resistance genes, nfxA and nfxB, were mapped hex-9001 and… Expand
Differences in susceptibility to quinolones of outer membrane mutants of Salmonella typhimurium and Escherichia coli.
- K. Hirai, H. Aoyama, T. Irikura, S. Iyobe, S. Mitsuhashi
- Biology, Medicine
- Antimicrobial Agents and Chemotherapy
- 1 March 1986
The mechanism of penetration of quinolones through the bacterial outer membrane was studied with lipopolysaccharide-deficient and porin-deficient mutants. The data indicated that the… Expand
Purification and properties of an inducible cephalosporinase from Pseudomonas maltophilia GN12873.
- Y. Saino, M. Inoue, S. Mitsuhashi
- Biology, Medicine
- Antimicrobial Agents and Chemotherapy
- 1 March 1984
An inducible cephalosporinase was purified from Pseudomonas maltophilia GN12873. The pI was 8.4, and the molecular weight was ca. 56,000 by gel filtration or 27,000 by sodium dodecyl… Expand
Purification and properties of inducible penicillin beta-lactamase isolated from Pseudomonas maltophilia.
- Y. Saino, F. Kobayashi, M. Inoue, S. Mitsuhashi
- Biology, Medicine
- Antimicrobial Agents and Chemotherapy
- 1 October 1982
Two types of beta-lactamase were found in the cell-free extract from Pseudomonas maltophilia GN12873. One was an inducible penicillin beta-lactamase, and the other was an inducible cephalosporin… Expand
Isolation and characterization of norfloxacin-resistant mutants of Escherichia coli K-12.
- K. Hirai, H. Aoyama, S. Suzue, T. Irikura, S. Iyobe, S. Mitsuhashi
- Biology, Medicine
- Antimicrobial Agents and Chemotherapy
- 1 August 1986
We isolated spontaneous mutants from Escherichia coli K-12 with low-level resistance to norfloxacin. These mutants were classified into the following three types on the basis of their properties: (i)… Expand
Mechanisms of high-level resistance to quinolones in urinary tract isolates of Pseudomonas aeruginosa.
- T. Yoshida, T. Muratani, S. Iyobe, S. Mitsuhashi
- Biology, Medicine
- Antimicrobial Agents and Chemotherapy
- 1 July 1994
Twenty-eight strains of Pseudomonas aeruginosa with various degrees of norfloxacin resistance were isolated from patients with urinary tract infections. P. aeruginosa strains (norfloxacin MICs, 3.13… Expand
Sequences of Homologous β-Lactamases from Clinical Isolates of Serratia marcescens with Different Substrate Specificities
- N. Matsumura, S. Minami, S. Mitsuhashi
- Medicine, Biology
- Antimicrobial Agents and Chemotherapy
- 1 January 1998
ABSTRACT Genes for two group 1 β-lactamases, SRT-1 and SST-1, were sequenced. These β-lactamases were produced by clinical isolates ofSerratia marcescens, isolates GN16694 and GN19450, respectively.… Expand
New Antipseudomonal Penicillin, PC-904: Affinity to Penicillin-Binding Proteins and Inhibition of the Enzyme Cross-Linking Peptidoglycan
- H. Noguchi, M. Matsuhashi, M. Takaoka, S. Mitsuhashi
- Biology, Medicine
- Antimicrobial Agents and Chemotherapy
- 1 October 1978
The mechanism of action of a new antipseudomonal penicillin, PC-904, was studied with respect to its binding affinities to penicillin-binding proteins (PBPs) and its inhibitory activities on… Expand
Cloning and expression in Enterobacteriaceae of the extended-spectrum beta-lactamase gene from a Pseudomonas aeruginosa plasmid.
- S. Iyobe, M. Tsunoda, S. Mitsuhashi
- Biology, Medicine
- FEMS microbiology letters
- 15 August 1994
An extended-spectrum beta-lactamase, the gene for which is located on plasmid pMS350 in Pseudomonas aeruginosa strains, hydrolyzes carbapenems and other extended-spectrum beta-lactam antibiotics. We… Expand