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N-Nitrosopyrrolidine

Known as: Pyrrolidine, 1-nitroso-, N-Nitrosopyrrolidine [Chemical/Ingredient], NPYR 
A clear, yellow, oily, liquid nitrosamine that decomposes when exposed to light and emits toxic fumes of nitrogen oxides when heated to decomposition… 
National Institutes of Health

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3-hydroxy-1-nitrosopyrrolidine
analogs & derivativesaspects of radiation effectschemical synthesisstandards characteristics

Papers overview

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2007
2007
Protective effect of vitamin C towards N-nitrosamine-induced DNA damage in the single-cell gel electrophoresis (SCGE)/HepG2 assay.
2007
2007
Genotoxicity screening for N-nitroso compounds. Electrochemical and electrochemiluminescent detection of human enzyme-generated DNA damage from N-nitrosopyrrolidine.
We report for the first time voltammetric/electrochemiluminescent sensors applied to predict genotoxicity of N-nitroso compounds… 
1995
1995
Reactions of alpha-acetoxy-N-nitrosopyrrolidine and alpha-acetoxy-N-nitrosopiperidine with deoxyguanosine: formation of N2-tetrahydrofuranyl and N2-tetrahydropyranyl adducts.
The goal of this study was to compare the reactions of alpha-acetoxy-N-nitrosopyrrolidine (alpha-acetoxyNPYR) and alpha-acetoxy-N… 
1991
1991
The genotoxicities of N-nitrosamines in Drosophila melanogaster in vivo: the correlation of mutagenicity in the wing spot test with the DNA damages detected by the DNA-repair test.
1990
1990
Mutagenesis by N-nitroso compounds: relationships to DNA adducts, DNA repair, and mutational efficiencies.
Highly Cited
1989
Highly Cited
1989
Detection of cyclic 1,N2-propanodeoxyguanosine adducts in DNA of rats treated with N-nitrosopyrrolidine and mice treated with crotonaldehyde.
Cyclic 1,N2-propanodeoxyguanosine adducts are formed in vitro in DNA treated with alpha-acetoxy-N-nitrosopyrrolidine or its… 
1988
1988
Identification of crotonaldehyde as a hepatic microsomal metabolite formed by alpha-hydroxylation of the carcinogen N-nitrosopyrrolidine.
Crotonaldehyde (2-butenal), which reacts with DNA and is mutagenic and carcinogenic, was identified as a hepatic microsomal… 
Review
1986
Review
1986
Relevance of N‐nitrosamines to esophageal cancer in China
Studies on the relevance of the N‐nitrosamines to esophageal cancer in China are reviewed. Esophageal cancer is a complex and… 
Highly Cited
1983
Highly Cited
1983
Formation of cyclic 1,N2--adducts by reaction of deoxyguanosine with alpha-acetoxy-N-nitrosopyrrolidine, 4-(carbethoxynitrosamino)butanal, or crotonaldehyde.
The structures of the DNA adducts formed in the metabolism of cyclic N -nitrosamines are not known. To approach this problem, we… 
Review
1980
Review
1980
The roles of tobacco, alcohol, and diet in the etiology of upper alimentary and respiratory tract cancers.
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