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Somatic point mutations in the p53 gene of human tumors and cell lines: updated compilation
This report describes the criteria for inclusion of data in this database, a description of the current format and a brief discussion of theCurrent relevance of p53 mutation analysis to clinical and biological questions. Expand
Database of p53 gene somatic mutations in human tumors and cell lines.
A data base is described in which over 2,500 mutations in the p53 gene of human tumors and tumor cell lines are compiled from a systematic search of reports published before 1 January 1994. Data fromExpand
Dietary intake of aflatoxins and the level of albumin-bound aflatoxin in peripheral blood in The Gambia, West Africa.
The validity of aflatoxin-albumin adducts as a marker of human exposure to this carcinogen is demonstrated and matched chronic hepatitis B surface antigen carriers with noncarriers did not reveal any difference in adduct formation. Expand
Aflatoxin M1 in human breast milk from The Gambia, west Africa, quantified by combined monoclonal antibody immunoaffinity chromatography and HPLC.
Data indicate that a rapid methodology exists to assess the levels of AFM1 excretion in human milk and to use this approach as a biomarker for exposure of children to this carcinogen. Expand
IARC Database of p53 gene mutations in human tumors and cell lines: updated compilation, revised formats and new visualisation tools
The criteria for inclusion of data, the revised format and the new visualisation tools for data retrieval are described, and the relevance of p 53 mutations to clinical and biological questions are discussed. Expand
A model of interaction: aflatoxins and hepatitis viruses in liver cancer aetiology and prevention.
Aflatoxin B1, the most commonly occurring and potent of the aflatoxins is associated with a specific AGG to AGT transversion mutation at codon 249 of the p53 gene in human HCC, providing mechanistic support to a causal link between exposure and disease. Expand
Absence of association between HPV DNA, TP53 codon 72 polymorphism, and risk of oesophageal cancer in a high-risk area of China.
The findings do not support the association between risk of oesophageal cancer, human papilloma virus infection, and TP53 codon 72 polymorphism in a Chinese population at high risk of OesophAGEal cancer. Expand
Altered expression of the cyclin D1 and retinoblastoma genes in human esophageal cancer.
The results suggest that the inhibitory effect of RB on cell cycle progression can be abrogated during tumor development either by loss of expression of the RB gene or by increased expression ofThe cyclin D1 gene. Expand
Hepatocellular carcinoma: from gene to public health.
The relevance of the biochemical/molecular markers of aflatoxin exposure, HBV vaccination, and the reduction of a Flatoxins exposure, in addition to the interaction between HBV infection and other risk factors in liver carcinogenesis, are discussed with regard to the implementation of measures for primary prevention. Expand
Genetic analysis of human esophageal tumors from two high incidence geographic areas: frequent p53 base substitutions and absence of ras mutations.
Esophageal squamous cell carcinoma (ESC) samples from patients residing in Uruguay and in Normandy, France, where alcoholic beverages and tobacco smoke are major risk factors, were analyzed for pointExpand