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N(5)-Formyltetrahydrofolate

Known as: 5 Formyltetrahydropteroylglutamate, 5-Formyltetrahydrofolate, 5 Formyltetrahydrofolate 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1964-2018
051019642018

Related topics

Related topics

8 relations

Narrower (5)

Elvorine, Isovorin, Levofolene, LevorinIsovorinLeucovorin 350 MG InjectionLeucovorin Calcium
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Broader (3)

FolacinFormyltetrahydrofolatesLeucovorin

Related mentions per year

Related mentions per year

1940-2018
19401960198020002020
N(5)-Formyltetrahydrofolate
Leucovorin
Leucovorin Calcium
levoleucovorin
Folacin
Formyltetrahydrofolates

Papers overview

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2008
2008
Polymorphisms in folate-related genes: association with side effects of high-dose methotrexate in childhood acute lymphoblastic leukemia
Acute lymphoblastic leukemia (ALL) is the most common form of cancer in children. Survival rates for ALL have improved… (More)
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2008
2008
The proton-coupled folate transporter: impact on pemetrexed transport and on antifolates activities compared with the reduced folate carrier.
The reduced folate carrier (RFC) and the proton-coupled folate transporter (PCFT) are ubiquitously expressed in normal and… (More)
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2005
2005
Higher plant plastids and cyanobacteria have folate carriers related to those of trypanosomatids.
Cyanobacterial and plant genomes encode proteins with some similarity to the folate and biopterin transporters of the… (More)
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Highly Cited
2004
Highly Cited
2004
A prominent low-pH methotrexate transport activity in human solid tumors: contribution to the preservation of methotrexate pharmacologic activity in HeLa cells lacking the reduced folate carrier.
Whereas the major folate transporter, the reduced folate carrier (RFC), has a physiological pH optimum, transport activities for… (More)
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Highly Cited
2004
Highly Cited
2004
Cerebral folate deficiency.
Cerebral folate deficiency (CFD) can be defined as any neurological syndrome associated with low cerebrospinal fluid (CSF) 5… (More)
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2000
2000
The mechanism of transport of the multitargeted antifolate (MTA) and its cross-resistance pattern in cells with markedly impaired transport of methotrexate.
MTA (LY231514) is an antifolate that targets multiple folate-dependent enzymes. In this report, MTA transport was characterized… (More)
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Highly Cited
1992
Highly Cited
1992
Microbiological assay on microtitre plates of folate in serum and red cells.
AIMS To develop a simple microbiological assay for serum and red cell folates on 96-well microtitre plates, suitable for use in… (More)
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1990
1990
Methotrexate transport in variant human CCRF-CEM leukemia cells with elevated levels of the reduced folate carrier. Selective effect on carrier-mediated transport of physiological concentrations of…
This study reports the isolation and characterization of a variant of the human CCRF-CEM leukemia cell line that overproduces the… (More)
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Highly Cited
1989
Highly Cited
1989
A new folate antimetabolite, 5,10-dideaza-5,6,7,8-tetrahydrofolate is a potent inhibitor of de novo purine synthesis.
5,10-Dideazatetrahydrofolate (DDATHF) is a new antimetabolite designed as an inhibitor of folate metabolism at sites other than… (More)
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1988
1988
Mediated uptake of folate by a high-affinity binding protein in sublines of L1210 cells adapted to nanomolar concentrations of folate
An L1210 cell line (JT-1), which can grow in medium supplemented with 1nm folate, has been isolated. These cells exhibit a slower… (More)
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