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Leucovorin

Known as: Leucovorin [Chemical/Ingredient], N-[4-[[(2-Amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amnio]benzoyl]-L-glutamic Acid, 5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic Acid 
A derivative of folic acid with chemoprotectant, antidote and synergistic activity. Leucovorin does not require metabolism by dihydrofolate reductase… 
National Institutes of Health

Related topics

Related topics

45 relations
10-formyl-7,8-dihydrofolic acidAnemia, PerniciousDrug AllergyDrug toxicity

Broader (3)

AntidoteFolacinFormyltetrahydrofolates

Narrower (26)

DCCM protocolELFE regimenEMACO protocolElvorine, Isovorin, Levofolene, Levorin

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2002
Highly Cited
2002
Prognostic value of tumoral thymidylate synthase and p53 in metastatic colorectal cancer patients receiving fluorouracil-based chemotherapy: phenotypic and genotypic analyses.
PURPOSE The aim of this multicenter prospective study was to evaluate the role of intratumoral parameters related to fluorouracil… 
Highly Cited
1997
Highly Cited
1997
Human intestinal folate transport: cloning, expression, and distribution of complementary RNA.
BACKGROUND & AIMS Despite intensive investigations, very little is known about the molecular identity(ies) of the intestinal… 
Highly Cited
1996
Highly Cited
1996
Phase I clinical and pharmacokinetic study of irinotecan, fluorouracil, and leucovorin in patients with advanced solid tumors.
PURPOSE To determine the maximum-tolerable dose (MTD) of fluorouracil (5FU) when given with fixed doses of leucovorin and… 
Highly Cited
1995
Highly Cited
1995
Highly enantioselective capillary electrophoretic separations with dilute solutions of the macrocyclic antibiotic ristocetin A.
Highly Cited
1993
Highly Cited
1993
Cigarette smoking and human papillomavirus in patients with reported cervical cytological abnormality.
OBJECTIVE--To assess the relation between two risk factors for cervical neoplasia: smoking and infection with oncogenic human… 
Highly Cited
1992
Highly Cited
1992
Chiral separation of leucovorin with bovine serum albumin using affinity capillary electrophoresis.
A method for the determination of the (6R)- and (6S)-stereoisomers of leucovorin using electrokinetic chromatography (EKC) in the… 
Review
1987
Review
1987
Overview of current status and future direction of clinical trials with 5-fluorouracil in combination with folinic acid.
Highly Cited
1986
Highly Cited
1986
Conservative treatment of ectopic pregnancy with methotrexate.
Highly Cited
1981
Highly Cited
1981
The influence of methotrexate pretreatment on 5-fluorouracil metabolism in L1210 cells.
Highly Cited
1961
Highly Cited
1961
Relation of folic acid reductase to amethopterin resistance in cultured mammalian cells.
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