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Leucovorin

Known as: Leucovorin [Chemical/Ingredient], N-[4-[[(2-Amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amnio]benzoyl]-L-glutamic Acid, 5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic Acid 
A derivative of folic acid with chemoprotectant, antidote and synergistic activity. Leucovorin does not require metabolism by dihydrofolate reductase… Expand
National Institutes of Health

Papers overview

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Review
2019
Review
2019
Importance Patients with locally advanced pancreatic cancer have historically poor outcomes. Evaluation of a total neoadjuvant… Expand
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Review
2018
Review
2018
The overall 5-year survival for pancreatic cancer has changed little over the past few decades, and pancreatic cancer is… Expand
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Review
2018
Review
2018
Purpose In 2016, ASCO published a guideline to assist in clinical decision making in metastatic pancreatic cancer for initial… Expand
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Review
2017
Review
2017
The objective of this systematic review was to provide current evidence regarding the use of adjuvant systemic chemotherapy for… Expand
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Review
2017
Review
2017
Pancreatic ductal adenocarcinoma (PDAC), commonly referred to as pancreatic cancer, ranks among the leading causes of cancer… Expand
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Review
2016
Review
2016
OBJECTIVE There is burgeoning interest in augmentation strategies for improving inadequate response to antidepressants. The… Expand
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Review
2016
Review
2016
BACKGROUND Pyridoxine-dependent epilepsy is a rare autosomal recessive epileptic encephalopathy caused by antiquitin (ALDH7A1… Expand
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Highly Cited
2004
Highly Cited
2004
BACKGROUND Bevacizumab, a monoclonal antibody against vascular endothelial growth factor, has shown promising preclinical and… Expand
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Highly Cited
2004
Highly Cited
2004
BACKGROUND The standard adjuvant treatment of colon cancer is fluorouracil plus leucovorin (FL). Oxaliplatin improves the… Expand
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Highly Cited
2000
Highly Cited
2000
PURPOSE In a previous study of treatment for advanced colorectal cancer, the LV5FU2 regimen, comprising leucovorin (LV) plus… Expand
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