Muzolimine

Known as: 3H-Pyrazol-3-one, 5-amino-2-(1-(3,4-dichlorophenyl)ethyl)-2,4-dihydro-, Muzolimine [Chemical/Ingredient]

A pyrazole diuretic with long duration and high capacity of action. It was proposed for kidney failure and hypertension but was withdrawn worldwide…

National Institutes of Health

Papers overview

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1993

The tubuloglomerular feedback mechanism is inhibited by diuretics such as furosemide. For the macula densa (MD) cells similar…

1985

Muzolimine, a new saliuretic, has been shown to combine high ceiling and long-acting effects in animal experiments. This study…

1985

The metabolism of muzolimine, 3-amino-1-(3,4-dichloro-alpha-methyl-benzyl)-2-pyrazoline-5-one has been studied both in vivo and…

1985

Thirty patients with moderate to severe hypertension (diastolic blood pressure greater than or equal to 115 mmHg), after a run-in…

1985

The importance of the urine volume and the residual functional capacity of the kidneys has been emphasized by several authors in…

1985

It is known that the diuretic activity of so-called loop diuretics is characterized by the ability of such compounds to inhibit…

1985

Muzolimine is a diuretic with chemical features different from all other known diuretics, and its use seem to be particularly…

1985

In a controlled double-blind study the effect of muzolimine (20 mg o.d.) and acebutolol (400 mg o.d.) were investigated in…

1983

A prospective evaluation was started in 1976 to study the influence of diuretics alone or combined with beta-blockers on serum…

1978

SummaryIn a double blind cross-over study of 11 patients suffering from advanced chronic renal failure, the diuretic effect of…