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Muzolimine

Known as: 3H-Pyrazol-3-one, 5-amino-2-(1-(3,4-dichlorophenyl)ethyl)-2,4-dihydro-, Muzolimine [Chemical/Ingredient] 
A pyrazole diuretic with long duration and high capacity of action. It was proposed for kidney failure and hypertension but was withdrawn worldwide… Expand
National Institutes of Health

Papers overview

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2005
2005
SummaryMuzolimine (10–500 μM) induced a concentration-dependent reduction of both the contractile force and frequency in… Expand
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Highly Cited
2004
Highly Cited
2004
The group of “high ceiling” diuretics consists of a variety of chemically different potent diuretic and saluretic substances… Expand
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2004
2004
Muzolimine produces a diuresis in the loop of Henle. Unlike other diuretics of this kind, the effect of muzolimine is slow and… Expand
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Highly Cited
1997
Highly Cited
1997
The aim of this study was to investigate the interaction between drugs chosen for their clinical neurotoxicity or chemical… Expand
1986
1986
Muzolimine is a loop diuretic with both the dosedepend increasing effectiveness of loop diurexctics and the long‐lasting effect… Expand
1985
1985
Muzolimine, a new saliuretic, has been shown to combine high ceiling and long-acting effects in animal experiments. This study… Expand
1985
1985
The metabolism of muzolimine, 3-amino-1-(3,4-dichloro-alpha-methyl-benzyl)-2-pyrazoline-5-one has been studied both in vivo and… Expand
1985
1985
Ten male cirrhotic patients with ascites and reduced renal function were randomly given equivalent doses of furosemide and… Expand
1981
1981
Muzolimine was administered by mouth to 24 patients with creatinine clearances ranging from 4 to 28 ml/min to treat oedema or… Expand
1977
1977
  • W. Ritter
  • Journal of chromatography
  • 1977
  • Corpus ID: 2045247
A sensitive and specific thin-layer densitometric method was developed for the determination of muzolimine (BAY g 2821), a… Expand