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Muzolimine

Known as: 3H-Pyrazol-3-one, 5-amino-2-(1-(3,4-dichlorophenyl)ethyl)-2,4-dihydro-, Muzolimine [Chemical/Ingredient] 
A pyrazole diuretic with long duration and high capacity of action. It was proposed for kidney failure and hypertension but was withdrawn worldwide… Expand
National Institutes of Health

Papers overview

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2005
2005
SummaryMuzolimine (10–500 μM) induced a concentration-dependent reduction of both the contractile force and frequency in… Expand
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1997
1997
The aim of this study was to investigate the interaction between drugs chosen for their clinical neurotoxicity or chemical… Expand
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1985
1985
Muzolimine, a new saliuretic, has been shown to combine high ceiling and long-acting effects in animal experiments. This study… Expand
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1985
1985
The metabolism of muzolimine, 3-amino-1-(3,4-dichloro-alpha-methyl-benzyl)-2-pyrazoline-5-one has been studied both in vivo and… Expand
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1985
1985
Ten male cirrhotic patients with ascites and reduced renal function were randomly given equivalent doses of furosemide and… Expand
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1985
1985
In a controlled double-blind study the effect of muzolimine (20 mg o.d.) and acebutolol (400 mg o.d.) were investigated in… Expand
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Highly Cited
1983
Highly Cited
1983
The group of “high ceiling” diuretics consists of a variety of chemically different potent diuretic and saluretic substances… Expand
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1982
1982
SummaryEighteen patients with mild impairment of renal function (glomerular filtration rate 65±5 ml/min: m±SEM) and hypertension… Expand
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1981
1981
SummaryThe pharmacodynamic effects of muzolimine and furosemide were compared in a single dose cross-over study in 8 patients on… Expand
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1977
1977
A sensitive and specific thin-layer densitometric method was developed for the determination of muzolimine (BAY g 2821), a… Expand
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