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Muzolimine

Known as: 3H-Pyrazol-3-one, 5-amino-2-(1-(3,4-dichlorophenyl)ethyl)-2,4-dihydro-, Muzolimine [Chemical/Ingredient] 
A pyrazole diuretic with long duration and high capacity of action. It was proposed for kidney failure and hypertension but was withdrawn worldwide… 
National Institutes of Health

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9 relations

Broader (2)

Antihypertensive AgentsDiuretics
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1987
1987
Inhibition of the Cl-/NaCO3- anion exchanger by xipamide in human red blood cells.
1987
1987
The diuretic effect of muzolimine
Muzolimine produces a diuresis in the loop of Henle. Unlike other diuretics of this kind, the effect of muzolimine is slow and… 
1986
1986
Effects of a new loop diuretic (muzolimine) in cirrhosis with ascites: Comparison with furosemide
Muzolimine is a loop diuretic with both the dosedepend increasing effectiveness of loop diurexctics and the long‐lasting effect… 
1985
1985
The metabolism of muzolimine.
The metabolism of muzolimine, 3-amino-1-(3,4-dichloro-alpha-methyl-benzyl)-2-pyrazoline-5-one has been studied both in vivo and… 
1985
1985
Clinical evaluation of muzolimine and indapamide during treatment for essential hypertension.
Muzolimine, a new saliuretic, has been shown to combine high ceiling and long-acting effects in animal experiments. This study… 
1985
1985
Comparative pharmacodynamics of furosemide and muzolimine in cirrhosis. Study on renal sodium and potassium handling and renin-aldosterone axis.
Ten male cirrhotic patients with ascites and reduced renal function were randomly given equivalent doses of furosemide and… 
1985
1985
Demonstration of action of muzolimine on the serosal side of Henle's loop cells.
Muzolimine, a new diuretic, is known to act by inhibiting Na transport along the ascending limb of Henle's loop. Because of its… 
1985
1985
Muzolimine and nitrendipine in the treatment of arterial hypertension.
Thirty patients with moderate to severe hypertension (diastolic blood pressure greater than or equal to 115 mmHg), after a run-in… 
1985
1985
Muzolimine in patients on chronic hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD).
The importance of the urine volume and the residual functional capacity of the kidneys has been emphasized by several authors in… 
1982
1982
Adequate substitution with electrolytes in toxicological testing of "loop" diuretics in the dog.
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