Muzolimine

Known as: 3H-Pyrazol-3-one, 5-amino-2-(1-(3,4-dichlorophenyl)ethyl)-2,4-dihydro-, Muzolimine [Chemical/Ingredient] 
A pyrazole diuretic with long duration and high capacity of action. It was proposed for kidney failure and hypertension but was withdrawn worldwide… (More)

Topic mentions per year

Topic mentions per year

1976-2016
051019762016

Papers overview

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1990
1990
Muzolimine (10–500 μM) induced a concentration-dependent reduction of both the contractile force and frequency in spontaneously… (More)
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1987
1987
Muzolimine produces a diuresis in the loop of Henle. Unlike other diuretics of this kind, the effect of muzolimine is slow and… (More)
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1985
1985
The metabolism of muzolimine, 3-amino-1-(3,4-dichloro-alpha-methyl-benzyl)-2-pyrazoline-5-one has been studied both in vivo and… (More)
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1985
1985
The effect of muzolimine (initial dose 60 mg followed by 30 mg/day for 14 days) on 15 patients with aortic and mitral… (More)
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1985
1985
This is an interim report of haemodynamic studies with oral muzolimine in male patients under 70 yr with haemodynamically… (More)
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1985
1985
Thirty patients with moderate to severe hypertension (diastolic blood pressure greater than or equal to 115 mmHg), after a run-in… (More)
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1984
1984
Muzolimine, 3-amino-1-(3,4-dichloro-alpha-methylbenzyl)-2- pyrazolin -5-one, an antihypertensive and diuretic drug, accumulates… (More)
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1983
1983
The group of “high ceiling” diuretics consists of a variety of chemically different potent diuretic and saluretic substances… (More)
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1982
1982
Eighteen patients with mild impairment of renal function (glomerular filtration rate 65±5 ml/min: m±SEM) and hypertension (168… (More)
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1978
1978
In a double blind cross-over study of 11 patients suffering from advanced chronic renal failure, the diuretic effect of single… (More)
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