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Moxonidine, a centrally acting antihypertensive agent, is a selective ligand for I1-imidazoline sites.
- P. Ernsberger, T. Damon, L. Graff, S. Schäfer, M. Christen
- Biology, ChemistryThe Journal of pharmacology and experimental…
The potent action of moxonidine on I1-imidazoline receptors may account for its antihypertensive efficacy.
A second generation of centrally acting antihypertensive agents act on putative I1-imidazoline receptors
The vasodepressor action of clonidine within its brainstem site of action in the ventrolateral medulla has been linked to a novel receptor that recognizes imidazoles and related compounds.
Tacrine-induced Reactive Oxygen Species in a Human Liver Cell Line: The Role of Anethole Dithiolethione as a Scavenger.
Quantification of two splicing events in the L-type calcium channel alpha-1 subunit of intestinal smooth muscle and other tissues.
From this quantitative study, carried out by PCR of reverse-transcribed mRNA, it clearly appears that the observed splicing processes in the IVS3-IVS4 region are not only tissue-dependent but also regulated during development.
Generation of slow wave type action potentials in the mouse small intestine involves a non-L-type calcium channel.
- J. Malysz, D. Richardson, L. Farraway, M. Christen, J. Huizinga
- BiologyCanadian journal of physiology and pharmacology
- 1 October 1995
The mouse small intestine has been established as a model for research into slow wave generation and electrical pacemaker activity and gradients in slow wave frequency, resting membrane potential, and occurrence of spiking activity were found.
A novel mechanism of action for hypertension control: Moxonidine as a selective I1-imidazoline agonist
- P. Ernsberger, M. Haxhiu, M. Christen
- Biology, ChemistryCardiovascular Drugs and Therapy
- 1 March 1994
In vivo studies in SHR rats confirmed the ability of moxonidine to normalize hypertension by an action within the RVLM and confirmed the correspondence of I1 binding affinity and antihypertensive efficacy.
Ultrastructural study of relationships between c-kit immunoreactive interstitial cells and other cellular elements in the human colon
- C. Mazzia, C. Porcher, Y. Julé, M. Christen, M. Henry
- BiologyHistochemistry and Cell Biology
- 1 May 2000
The results of the present study shed essential light on the relationships of c-kit immunoreactive interstitial cells with the neighboring muscle cells and nerve elements, and confirm that the intercalated c-Kit ICs well fit with the so-called "interstitial cells of Cajal".
I1-imidazoline-receptor agonists in the treatment of hypertension: an appraisal of clinical experience.
Because of its especially favorable benefit-to-risk ratio, moxonidine should be recommended as first-line treatment of hypertension and may also be useful in treating related problems such as LVH, coronary artery disease, and ventricular premature beats.
Anethole dithiolethione: biochemical considerations.
- M. Christen
- Biology, ChemistryMethods in enzymology