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MutL Protein Homolog 1
Known as:
Colon Cancer, Nonpolyposis Type 2 Protein
, COCA2 Protein
, MLH1 Protein
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Eukaryotic homolog of the bacterial MutL DNA MISMATCH REPAIR protein. It heterodimerizes with MISMATCH REPAIR ENDONUCLEASE PMS2 to form MutL alpha…
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National Institutes of Health
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Related topics
Related topics
9 relations
In Blood
MLH1 gene
Process of secretion
antagonists & inhibitors
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Narrower (1)
MLH1 protein, human
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Structural Features and Functional Dependency on β-Clamp Define Distinct Subfamilies of Bacterial Mismatch Repair Endonuclease MutL*
K. Fukui
,
S. Baba
,
T. Kumasaka
,
T. Yano
The Journal of Biological Chemistry
2016
Corpus ID: 6509031
In early reactions of DNA mismatch repair, MutS recognizes mismatched bases and activates MutL endonuclease to incise the error…
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2015
2015
FancJ (Brip1) loss-of-function allele results in spermatogonial cell depletion during embryogenesis and altered processing of crossover sites during meiotic prophase I in mice
X. Sun
,
M. Brieño-Enríquez
,
+5 authors
P. Cohen
Chromosoma
2015
Corpus ID: 13758825
Fancj, the gene associated with Fanconi anemia (FA) Complementation Group J, encodes a DNA helicase involved in homologous…
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2013
2013
Complex Relationship between Mismatch Repair Proteins and MBD4 during Immunoglobulin Class Switch Recombination
F. Grigera
,
A. Bellacosa
,
A. Kenter
PloS one
2013
Corpus ID: 8157877
Mismatch repair (MMR) safeguards against genomic instability and is required for efficient Ig class switch recombination (CSR…
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2011
2011
Impact of Ciprofloxacin Exposure on Staphylococcus aureus Genomic Alterations Linked with Emergence of Rifampin Resistance
Jean-Philippe Didier
,
R. Villet
,
+4 authors
P. Vaudaux
Antimicrobial Agents and Chemotherapy
2011
Corpus ID: 30609096
ABSTRACT Intensive use of antimicrobial agents in health care settings not only leads to the selection of multiresistant…
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2011
2011
Non-Steroidal Anti-Inflammatory Drugs, DNA Repair and Cancer
H. Dibra
,
C. Perry
,
I. Nicholl
2011
Corpus ID: 22583060
Colorectal cancer is the third most common cancer in women and fourth in men, with respect to incidence, and 529,000 deaths…
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2009
2009
Functional properties of the thermostable mutL from Thermotoga maritima.
Tae Gyun Kim
,
Seong-Dal Heo
,
Jakang Ku
,
C. Ban
BMB reports
2009
Corpus ID: 25728729
The methyl-directed mismatch repair (MMR) mechanism has been extensively studied in vitro and in vivo, but one of the…
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2006
2006
The DNA Binding Activity of MutL Is Required for Methyl-directed Mismatch Repair in Escherichia coli*
A. Robertson
,
Steven R Pattishall
,
S. W. Matson
Journal of Biological Chemistry
2006
Corpus ID: 41544041
The DNA binding properties of the mismatch repair protein MutL and their importance in the repair process have been controversial…
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2003
2003
Apoptosis and mutation in the murine small intestine: loss of Mlh1- and Pms2-dependent apoptosis leads to increased mutation in vivo.
O. Sansom
,
S. M. Bishop
,
Helen R Court
,
S. Dudley
,
R. Liskay
,
A. Clarke
DNA repair
2003
Corpus ID: 22622916
2003
2003
Human mismatch-repair protein MutL homologue 1 (MLH1) interacts with Escherichia coli MutL and MutS in vivo and in vitro: a simple genetic system to assay MLH1 function.
B. Quaresima
,
P. Alifano
,
P. Tassone
,
E. Avvedimento
,
F. Costanzo
,
S. Venuta
The Biochemical journal
2003
Corpus ID: 11300029
A simple genetic system has been developed to test the effect of over-expression of wild-type or mutated human MutL homologue 1…
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Highly Cited
1996
Highly Cited
1996
Transcription of the mutL repair, miaA tRNA modification, hfq pleiotropic regulator, and hflA region protease genes of Escherichia coli K-12 from clustered Esigma32-specific promoters during heat…
H. C. Tsui
,
G. Feng
,
M. Winkler
Journal of bacteriology
1996
Corpus ID: 25222458
The amiB-mutL-miaA-hfq-hflX-hflK-hflC superoperon of Escherichia coli contains genes that are important for diverse cellular…
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