MutL Protein Homolog 1

Known as: Colon Cancer, Nonpolyposis Type 2 Protein, COCA2 Protein, MLH1 Protein 
Eukaryotic homolog of the bacterial MutL DNA MISMATCH REPAIR protein. It heterodimerizes with MISMATCH REPAIR ENDONUCLEASE PMS2 to form MutL alpha… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2000-2017
0520002017

Papers overview

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2017
2017
Molecular alterations in genes involved in DNA mismatch repair (MMR) promote cancer initiation and foster tumour progression… (More)
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2014
2014
To determine the relevance of O-6-methylguanine-DNA methyltransferase (MGMT), human mutS homolog 2 (hMSH2), and human mutL… (More)
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2013
2013
MicroRNAs (miRNAs) and DNA mismatch repair (MMR) have been linked to human cancer progression. Human mutL homolog 1 (hMLH1), one… (More)
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2013
2013
Mismatch repair (MMR) safeguards against genomic instability and is required for efficient Ig class switch recombination (CSR… (More)
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2008
2008
DNA interstrand crosslinks (ICLs) are among the most toxic types of damage to a cell. For this reason, many ICL-inducing agents… (More)
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2006
2006
BACKGROUND Methylation-mediated suppression of detoxification, DNA repair, and tumor suppressor genes has been implicated in… (More)
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2006
2006
Monoclonal gammopathies are a group of disorders characterized by clonal proliferation and accumulation of immunoglobulin… (More)
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2003
2003
Patients who develop tumors with Lynch syndrome, which is caused by mutational inactivation of the DNA mismatch repair (MMR… (More)
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2003
2003
The mismatch repair (MMR) protein Msh2 has been shown to function in the apoptotic response to alkylating agents in vivo. Here… (More)
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