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MutL Protein Homolog 1

Known as: Colon Cancer, Nonpolyposis Type 2 Protein, COCA2 Protein, MLH1 Protein 
Eukaryotic homolog of the bacterial MutL DNA MISMATCH REPAIR protein. It heterodimerizes with MISMATCH REPAIR ENDONUCLEASE PMS2 to form MutL alpha… 
National Institutes of Health

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In BloodMLH1 geneProcess of secretionantagonists & inhibitors

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MLH1 protein, human

Papers overview

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2018
2018
Promoter methylation of human mutL homolog 1 and colorectal cancer risk: A meta-analysis
Aims: Several studies suggested that promoter methylation of human mutL homolog 1 (hMLH1) was associated with the risk of… 
2018
2018
Abstract 5723: Inactivation of DNA repair triggers neoantigen generation and impairs tumor growth
Colorectal, ovarian, endometrial and other tumors carrying defects in DNA mismatch repair often show favorable prognosis and… 
2013
2013
Reduced expression of mutS homolog 2 and mutL homolog 1 affects overall survival in laryngeal squamous cell carcinoma patients: Investigation into a potential cause.
The risk factors affecting the survival rates of laryngeal carcinoma are not well understood. In this study, we investigated the… 
2011
2011
Non-Steroidal Anti-Inflammatory Drugs, DNA Repair and Cancer
Colorectal cancer is the third most common cancer in women and fourth in men, with respect to incidence, and 529,000 deaths… 
2011
2011
Residue sequence conservation and crosslinking results mapped onto the structures of MutH (pdb code 2azo chain B), MutL NTD (pdb code 1b63) and MutL CTD pdb code 1x9z, ()
2008
2008
Sex-specific crossover patterns in Zebrafish (Danio rerio)
Some species display intersex variation in their rate of meiotic recombination, where recombination is usually suppressed in the… 
2007
2007
Immunohistochemical staining for mismatch repair proteins, and its relevance in the diagnosis of hereditary non‐polyposis colorectal cancer
Hereditary non‐polyposis colorectal cancer (HNPCC) arises mostly from germline mutations of the mismatch repair genes MSH2 and… 
2005
2005
Sebaceous adenoma of the eyelid in Muir-Torre syndrome.
Muir-Torre syndrome is a rare cancer predisposition syndrome characterized by unusual cutaneous tumors and internal malignancy… 
2003
2003
Apoptosis and mutation in the murine small intestine: loss of Mlh1- and Pms2-dependent apoptosis leads to increased mutation in vivo.
2003
2003
Frequent genomic disorganisation of MLH1 in hereditary non-polyposis colorectal cancer (HNPCC) screened by RT-PCR on puromycin treated samples
Hereditary non-polyposis colorectal cancer (HNPCC) is a dominantly inherited autosomal disease presumed to comprise at least 5-8… 
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