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MutL Protein Homolog 1

Known as: Colon Cancer, Nonpolyposis Type 2 Protein, COCA2 Protein, MLH1 Protein 
Eukaryotic homolog of the bacterial MutL DNA MISMATCH REPAIR protein. It heterodimerizes with MISMATCH REPAIR ENDONUCLEASE PMS2 to form MutL alpha… 
National Institutes of Health

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In BloodMLH1 geneProcess of secretionantagonists & inhibitors
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MLH1 protein, human

Papers overview

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2016
2016
Structural Features and Functional Dependency on β-Clamp Define Distinct Subfamilies of Bacterial Mismatch Repair Endonuclease MutL*
In early reactions of DNA mismatch repair, MutS recognizes mismatched bases and activates MutL endonuclease to incise the error… 
2015
2015
FancJ (Brip1) loss-of-function allele results in spermatogonial cell depletion during embryogenesis and altered processing of crossover sites during meiotic prophase I in mice
Fancj, the gene associated with Fanconi anemia (FA) Complementation Group J, encodes a DNA helicase involved in homologous… 
2013
2013
Complex Relationship between Mismatch Repair Proteins and MBD4 during Immunoglobulin Class Switch Recombination
Mismatch repair (MMR) safeguards against genomic instability and is required for efficient Ig class switch recombination (CSR… 
2011
2011
Impact of Ciprofloxacin Exposure on Staphylococcus aureus Genomic Alterations Linked with Emergence of Rifampin Resistance
ABSTRACT Intensive use of antimicrobial agents in health care settings not only leads to the selection of multiresistant… 
2011
2011
Non-Steroidal Anti-Inflammatory Drugs, DNA Repair and Cancer
Colorectal cancer is the third most common cancer in women and fourth in men, with respect to incidence, and 529,000 deaths… 
2009
2009
Functional properties of the thermostable mutL from Thermotoga maritima.
The methyl-directed mismatch repair (MMR) mechanism has been extensively studied in vitro and in vivo, but one of the… 
2006
2006
The DNA Binding Activity of MutL Is Required for Methyl-directed Mismatch Repair in Escherichia coli*
The DNA binding properties of the mismatch repair protein MutL and their importance in the repair process have been controversial… 
2003
2003
Apoptosis and mutation in the murine small intestine: loss of Mlh1- and Pms2-dependent apoptosis leads to increased mutation in vivo.
2003
2003
Human mismatch-repair protein MutL homologue 1 (MLH1) interacts with Escherichia coli MutL and MutS in vivo and in vitro: a simple genetic system to assay MLH1 function.
A simple genetic system has been developed to test the effect of over-expression of wild-type or mutated human MutL homologue 1… 
Highly Cited
1996
Highly Cited
1996
Transcription of the mutL repair, miaA tRNA modification, hfq pleiotropic regulator, and hflA region protease genes of Escherichia coli K-12 from clustered Esigma32-specific promoters during heat…
The amiB-mutL-miaA-hfq-hflX-hflK-hflC superoperon of Escherichia coli contains genes that are important for diverse cellular… 
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