MLH1 gene

Known as: MutL Homolog 1 Gene, HNPCC, HNPCC2 
This gene plays a role in DNA mismatch repair.

Topic mentions per year

Topic mentions per year

1985-2017
02040608019852017

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2004
Highly Cited
2004
Epigenetic silencing can mimic genetic mutation by abolishing expression of a gene. We hypothesized that an epimutation could… (More)
  • figure 1
  • table 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2001
Highly Cited
2001
High-level microsatellite instability (MSI-H) is demonstrated in 10 to 15% of sporadic colorectal cancers and in most cancers… (More)
Is this relevant?
Highly Cited
1999
Highly Cited
1999
Loss of DNA mismatch repair due to mutation or diminished expression of the MLH1 gene is associated with genome instability and… (More)
  • table 1
  • figure 1
  • table 2
  • figure 2
  • table 3
Is this relevant?
1999
1999
An3 1 KAL I MutL homologue 1 (MLH1) is a member of the family of proteins required for DNA mismatch repair. Germ-line mutations… (More)
Is this relevant?
Highly Cited
1996
Highly Cited
1996
Germ line mutations in DNA mismatch repair genes including MLH1 cause hereditary nonpolyposis colon cancer. To understand the… (More)
  • figure 1
  • figure 3
  • figure 4
  • figure 5
  • figure 6
Is this relevant?
Highly Cited
1996
Highly Cited
1996
BACKGROUND & AIMS Microsatellite instability (replication error [RER]) is a characteristic of tumors in hereditary nonpolyposis… (More)
Is this relevant?
Highly Cited
1995
Highly Cited
1995
Identification of hereditary non-polyposis colorectal cancer (HNPCC) indicates theoretical life-time risks of 50% for the… (More)
Is this relevant?
Highly Cited
1994
Highly Cited
1994
A replication error (RER) phenotype has been documented both in sporadic colorectal tumors and in tumors from patients with… (More)
  • table 1
  • figure 1
  • table 2
Is this relevant?
Highly Cited
1994
Highly Cited
1994
The mechanism by which germline mutations of DNA mismatch repair genes cause susceptibility to tumour formation is not yet… (More)
Is this relevant?