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MLH1 wt Allele

Known as: MGC5172, HNPCC2, COCA2 
Human MLH1 wild-type allele is located in the vicinity of 3p21.3 and is approximately 57 kb in length. This allele, which encodes DNA mismatch repair… 
National Institutes of Health

Related topics

Related topics

8 relations
3p21.3DNA RepairHereditary Non-Polyposis Colon Cancer Type 2Homo sapiens

Broader (1)

MLH1 gene

Papers overview

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2011
2011
Two novel mutations in hMLH1 gene in Iranian hereditary non-polyposis colorectal cancer patients
Hereditary non-polyposis colorectal cancer (HNPCC) is one of the most common forms of hereditary colorectal cancer. It is an… 
2011
2011
Microsatellite instability in young patients with sporadic colorectal adenomas.
BACKGROUND/AIMS This study was designed to determine the prevalence of microsatellite instability (MSI) among colorectal adenomas… 
2008
2008
Hypermethylation status of APC inversely correlates with the presence of submucosal invasion in laterally spreading colorectal tumors
Little is known about epigenetic alterations in laterally spreading colorectal tumors (LSTs). The goal of the present study was… 
2006
2006
Hypermethylation of Chfr and hMLH1 in gastric noninvasive and early invasive neoplasias
2006
2006
Hypermethylation of the hMLHl Promoter in Colon Cancer with Microsatellite Instability 1
Recent studies have demonstrated the presence of microsatellite insta bility (MSI) in tumors from patients with hereditary… 
2003
2003
Frequent Loss of hMLH 1 by Promoter Hypermethylation Leads to Microsatellite Instability in Adenomatous Polyps of Patients with a Single First-Degree Member Affected by Colon Cancer 1
The first-degree relatives of patients affected by colorectal cancer, who do not belong to familial adenomatous polyposis and… 
2000
2000
Hypermethylation of Multiple Genes in Pancreatic Adenocarcinoma 1
Hypermethylation of CpG islands is a common mechanism by which tumor suppressor genes are inactivated. We studied 45 pancreatic… 
1999
1999
Advances in Brief Neurofibromatosis and Early Onset of Cancers in h MLH 1-deficient Children 1
Hereditary nonpolyposis colon cancer is a common hereditary disorder caused by the germ-line mutations of DNA mismatch repair… 
1996
1996
Microsatellite instability and loss of heterozygosity at the hMLH1 locus on chromosome 3p21 occur in a subset of nonsmall cell lung carcinomas.
Microsatellite alterations observed in tumor specimens may reflect genomic instability due to defective mismatch repair genes. To… 
1994
1994
Correction des erreurs dans l'ADN : de la génétique bactérienne aux mécanismes de prédisposition héréditaire aux cancers chez l'homme
D'apres le journal Science du 1 8 mars 1 994, il n ' a fal lu que << q uelques minutes , pour identifier le deuxie­ me gene…