MLH1 wt Allele

Known as: MGC5172, HNPCC2, COCA2 
Human MLH1 wild-type allele is located in the vicinity of 3p21.3 and is approximately 57 kb in length. This allele, which encodes DNA mismatch repair… (More)

Topic mentions per year

Topic mentions per year

1994-2018
05010019942018

Papers overview

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Highly Cited
2003
Highly Cited
2003
Hypermethylation of CpG islands in the promoter regions is an important mechanism to silence the expression of many important… (More)
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Highly Cited
2001
Highly Cited
2001
We are in an era where the potential exists for deriving comprehensive profiles of DNA alterations characterizing each form of… (More)
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Highly Cited
1999
Highly Cited
1999
Aberrant methylation of promoter region CpG islands is associated with transcriptional inactivation of tumor-suppressor genes in… (More)
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Highly Cited
1998
Highly Cited
1998
Inactivation of the genes involved in DNA mismatch repair is associated with microsatellite instability (MSI) in colorectal… (More)
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Highly Cited
1998
Highly Cited
1998
Recent studies have demonstrated the presence of microsatellite instability (MSI) in tumors from patients with hereditary… (More)
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Highly Cited
1997
Highly Cited
1997
Somatic mutations in DNA mismatch repair genes have been observed in sporadic tumors as well as cell lines and xenografts derived… (More)
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Highly Cited
1996
Highly Cited
1996
BACKGROUND & AIMS Hereditary nonpolyposis colorectal cancer is characterized by early-onset colorectal cancer and the occurrence… (More)
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Highly Cited
1994
Highly Cited
1994
The human DNA mismatch repair gene homologue hMSH2, on chromosome 2p is involved in hereditary non-polyposis colon cancer (HNPCC… (More)
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Highly Cited
1994
Highly Cited
1994
Some cases of hereditary nonpolyposis colorectal cancer (HNPCC) are due to alterations in a mutS-related mismatch repair gene. A… (More)
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Highly Cited
1994
Highly Cited
1994
Hereditary nonpolyposis colorectal cancer (HNPCC) is one of man's commonest hereditary diseases. Several studies have implicated… (More)
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