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MLH1 wt Allele

Known as: MGC5172, HNPCC2, COCA2 
Human MLH1 wild-type allele is located in the vicinity of 3p21.3 and is approximately 57 kb in length. This allele, which encodes DNA mismatch repair… 
National Institutes of Health

Related topics

Related topics

8 relations
3p21.3DNA RepairHereditary Non-Polyposis Colon Cancer Type 2Homo sapiens

Broader (1)

MLH1 gene

Papers overview

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Highly Cited
2004
Highly Cited
2004
Relationship between CDX2 gene methylation and dietary factors in gastric cancer patients.
Epigenetic gene silencing through DNA methylation is one of the important steps in the mechanism underlying tumorigenesis… 
Highly Cited
2002
Highly Cited
2002
Involvement of hMSH6 in the development of hereditary and sporadic colorectal cancer revealed by immunostaining is based on germline mutations, but rarely on somatic inactivation
Germline mutations in human mismatch repair (MMR) genes yield a predisposition for the hereditary nonpolyposis colon cancer… 
Highly Cited
2001
Highly Cited
2001
Loss of DNA mismatch repair imparts defective cdc2 signaling and G(2) arrest responses without altering survival after ionizing radiation.
Our previous data demonstrated that cells deficient in MutL homologue-1 (MLH1) expression had a reduced and shorter G(2) arrest… 
Highly Cited
2001
Highly Cited
2001
Alterations of Mismatch Repair Protein Expression in Benign Melanocytic Nevi, Melanocytic Dysplastic Nevi, and Cutaneous Malignant Melanomas
Immunoperoxidase-staining methods were used to examine the expression of hMLH1, hMSH2, and hMSH6 mismatch repair (MMR) proteins… 
Highly Cited
2001
Highly Cited
2001
High frequency of microsatellite instability in young patients with head‐and‐neck squamous‐cell carcinoma: Lack of involvement of the mismatch repair genes hMLH1 AND hMSH2
The most prevalent risk factors in the development of head‐and‐neck squamous‐cell carcinoma (HNSCC) are excessive tobacco and… 
Highly Cited
2000
Highly Cited
2000
Methylation of the hMLH1 promoter but no hMLH1 mutations in sporadic gastric carcinomas with high‐level microsatellite instability
Microsatellite instability (MSI) in tumors from patients with hereditary non‐polyposis colorectal cancer (HNPCC) is caused by… 
Highly Cited
1999
Highly Cited
1999
Mechanisms of inactivation of mismatch repair genes in human colorectal cancer cell lines: the predominant role of hMLH1.
Fifteen to twenty-five percent of sporadic colorectal carcinomas are replication error (RER) positive. Because the frequency of… 
Highly Cited
1999
Highly Cited
1999
Correlation of methylation of the hMLH1 promoter with lack of expression of hMLH1 in sporadic gastric carcinomas with replication error.
Recent studies have demonstrated that the majority of sporadic colorectal carcinomas with replication error (RER) do not harbor… 
Highly Cited
1997
Highly Cited
1997
Genetic testing is important in families with a history suggestive of hereditary non‐olyposis colorectal cancer even if the Amsterdam criteria are not fulfilled
BACKGROUND Clinical screening is still the first-line approach to identification of families with hereditary non-polyposis… 
Highly Cited
1995
Highly Cited
1995
Detection of new mutations in six out of 10 Swiss HNPCC families by genomic sequencing of the hMSH2 and hMLH1 genes.
The cancer predisposition in most HNPCC families is believed to be associated with mutations in the human mismatch repair gene… 
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