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3p21.3

A chromosome band present on 3p
National Institutes of Health

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18 relations
APEH wt AlleleCCBP2 wt AlleleCCR3 wt AlleleCCR9 wt Allele
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Papers overview

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Review
2007
Review
2007
The RASSF1A tumor suppressor
RASSF1A (Ras association domain family 1 isoform A) is a recently discovered tumor suppressor whose inactivation is implicated in… Expand
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Highly Cited
2001
Highly Cited
2001
Methylation associated inactivation of RASSF1A from region 3p21.3 in lung, breast and ovarian tumours
Previously we analysed overlapping homozygous deletions in lung and breast tumours/tumour lines and defined a small region of 120… Expand
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Highly Cited
2001
Highly Cited
2001
Inhibition of lung cancer cell growth and induction of apoptosis after reexpression of 3p21.3 candidate tumor suppressor gene SEMA3B
Semaphorins SEMA3B and its homologue SEMA3F are 3p21.3 candidate tumor suppressor genes (TSGs), the expression of which is… Expand
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Highly Cited
2001
Highly Cited
2001
The candidate tumor suppressor gene, RASSF1A, from human chromosome 3p21.3 is involved in kidney tumorigenesis
Clear cell-type renal cell carcinomas (clear RCC) are characterized almost universally by loss of heterozygosity on chromosome 3p… Expand
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Highly Cited
2001
Highly Cited
2001
Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression.
BACKGROUND The recently identified RASSF1 locus is located within a 120-kilobase region of chromosome 3p21.3 that frequently… Expand
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Highly Cited
2000
Highly Cited
2000
Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3
Allelic loss at the short arm of chromosome 3 is one of the most common and earliest events in the pathogenesis of lung cancer… Expand
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Highly Cited
2000
Highly Cited
2000
The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome…
We used overlapping and nested homozygous deletions, contig building, genomic sequencing, and physical and transcript mapping to… Expand
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Highly Cited
1998
Highly Cited
1998
BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression
We have identified a novel protein, BAP1, which binds to the RING finger domain of the Breast/Ovarian Cancer Susceptibility Gene… Expand
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Highly Cited
1996
Highly Cited
1996
Human semaphorins A(V) and IV reside in the 3p21.3 small cell lung cancer deletion region and demonstrate distinct expression patterns.
Semaphorins and collapsins make up a family of conserved genes that encode nerve growth cone guidance signals. We have identified… Expand
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Highly Cited
1994
Highly Cited
1994
Mutation in the DNA mismatch repair gene homologue hMLH 1 is associated with hereditary non-polyposis colon cancer
THE human DNA mismatch repair gene homologue, hMSH2, on chromosome 2p is involved in hereditary non-polyposis colon cancer (HNPCC… Expand
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