3p21.3

A chromosome band present on 3p
National Institutes of Health

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17 relations
APEH wt AlleleCCBP2 wt AlleleCCR3 wt AlleleCCR9 wt Allele
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Highly Cited
2004
Highly Cited
2004
Frequent epigenetic inactivation of RASSF1A and BLU genes located within the critical 3p21.3 region in gliomas
RASSF1A is a major tumor suppressor gene located at 3p21.3. We investigated the role of aberrant promoter region hypermethylation… (More)
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Highly Cited
2002
Highly Cited
2002
Semaphorin 3F gene from human 3p21.3 suppresses tumor formation in nude mice.
Loss of heterozygosity on human chromosome 3p21.3 is a frequent occurrence in many tumor types. In a previous study, our… (More)
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Highly Cited
2002
Highly Cited
2002
Human Semaphorin 3B (SEMA3B) located at chromosome 3p21.3 suppresses tumor formation in an adenocarcinoma cell line.
The short arm of chromosome 3 has been shown to exhibit high loss of heterozygosity in several types of cancer including ovarian… (More)
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Highly Cited
2001
Highly Cited
2001
The candidate tumor suppressor gene, RASSF1A, from human chromosome 3p21.3 is involved in kidney tumorigenesis.
Clear cell-type renal cell carcinomas (clear RCC) are characterized almost universally by loss of heterozygosity on chromosome 3p… (More)
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Highly Cited
2001
Highly Cited
2001
Epigenetic inactivation of the RASSF1A 3p21.3 tumor suppressor gene in both clear cell and papillary renal cell carcinoma.
Renal cell carcinoma (RCC), the most common adult kidney neoplasm, is histopathologically heterogeneous, with most sporadic RCCs… (More)
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Highly Cited
2001
Highly Cited
2001
Methylation associated inactivation of RASSF1A from region 3p21.3 in lung, breast and ovarian tumours
Previously we analysed overlapping homozygous deletions in lung and breast tumours/tumour lines and defined a small region of 120… (More)
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Highly Cited
2001
Highly Cited
2001
Hypermethylation of the cpG island of Ras association domain family 1A (RASSF1A), a putative tumor suppressor gene from the 3p21.3 locus, occurs in a large percentage of human breast cancers.
The human Ras association domain family 1A gene (RASSF1A), recently cloned from the lung tumor suppressor locus 3p21.3, was shown… (More)
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Highly Cited
2001
Highly Cited
2001
Inhibition of lung cancer cell growth and induction of apoptosis after reexpression of 3p21.3 candidate tumor suppressor gene SEMA3B.
Semaphorins SEMA3B and its homologue SEMA3F are 3p21.3 candidate tumor suppressor genes (TSGs), the expression of which is… (More)
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Highly Cited
2000
Highly Cited
2000
Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3
Allelic loss at the short arm of chromosome 3 is one of the most common and earliest events in the pathogenesis of lung cancer… (More)
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Highly Cited
1996
Highly Cited
1996
Distinct 3p21.3 deletions in lung cancer and identification of a new human semaphorin.
Loss of chromosome 3p is a critical event in the pathogenesis of lung cancer. Overlapping homozygous 3p21.3 deletions in lung… (More)
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