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The Transcriptional Landscape of the Mammalian Genome
TLDR
Detailed polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs derived from the mouse genome provide a comprehensive platform for the comparative analysis of mammalian transcriptional regulation in differentiation and development.
Isolation and sequencing of the Epstein-Barr virus BNLF-1 gene (LMP1) from a Chinese nasopharyngeal carcinoma.
The BamHI fragment containing the Epstein-Barr virus (EBV) LMP1 gene was cloned from a genomic library of the nude mouse-propagated Chinese nasopharyngeal carcinoma CAO. The sequence of the LMP1 gene
Tumor suppressor genes on chromosome 3p involved in the pathogenesis of lung and other cancers
TLDR
It is clear now that genetic and epigenetic abnormalities of several genes residing in chromosome region 3p are important for the development of lung cancers but it is still obscure how many of them exist and which of the numerous candidate TSGs are the key players in lung cancer pathogenesis.
Cloning of two candidate tumor suppressor genes within a 10 kb region on chromosome 13q14, frequently deleted in chronic lymphocytic leukemia
TLDR
It is concluded that the Leu1 and Leu2 genes are strong candidates as tumor suppressor gene(s) involved in B-CLL leukemogenesis.
Construction of a 600-kilobase cosmid clone contig and generation of a transcriptional map surrounding the lung cancer tumor suppressor gene (TSG) locus on human chromosome 3p21.3: progress toward
TLDR
The construction of a 700-kb (cosmid and one P1 phage) clone contig covering the deletion overlap and its flanks is reported, which will prove crucial in the identification of the lung cancer TSG(s).
Functional Characterization of the Candidate Tumor Suppressor Gene NPRL2/G21 Located in 3p21.3C
TLDR
It is confirmed that NPRL2 is a multiple tumor suppressor gene and speculated that the NPRL 2/G21 nuclear protein may be involved in mismatch repair, cell cycle checkpoint signaling, and activation of apoptotic pathway(s).
The candidate tumor suppressor gene, RASSF1A, from human chromosome 3p21.3 is involved in kidney tumorigenesis
TLDR
Data suggest that RASSF1A is the candidate renal TSG gene for the 3p21.3 region, which usually involves any combination of three regions: 3p25-p26 (harboring the VHL gene), 3p12-p14.2 (containing the FHIT gene), and3p21-p22, implying inactivation of the resident tumor-suppressor genes (TSGs).
Extracellular protease ADAMTS9 suppresses esophageal and nasopharyngeal carcinoma tumor formation by inhibiting angiogenesis.
TLDR
The results indicate that ADAMTS9 contributes an important function in the tumor microenvironment that acts to inhibit angiogenesis and tumor growth in both ESCC and NPC.
RBSP3 (HYA22) is a tumor suppressor gene implicated in major epithelial malignancies.
TLDR
This study performs an initial analysis of RBSP3/HYA22, a candidate tumor suppressor genes located in the AP20 region, and identifies two sequence splice variants that belong to a gene family of small C-terminal domain phosphatases that may control the RNA polymerase II transcription machinery.
Differential Expression of CHL1 Gene during Development of Major Human Cancers
TLDR
The role of CHL1 as a potentially novel specific biomarker in the early pathogenesis of two major histological types of renal cancer is supported and suggested that re-expression of the gene on the edge of tumor mass might promote local invasive growth and enable further metastatic spread in ovary, colon and breast cancer.
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