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Cloning of two candidate tumor suppressor genes within a 10 kb region on chromosome 13q14, frequently deleted in chronic lymphocytic leukemia
TLDR
It is concluded that the Leu1 and Leu2 genes are strong candidates as tumor suppressor gene(s) involved in B-CLL leukemogenesis.
Construction of a 600-kilobase cosmid clone contig and generation of a transcriptional map surrounding the lung cancer tumor suppressor gene (TSG) locus on human chromosome 3p21.3: progress toward
TLDR
The construction of a 700-kb (cosmid and one P1 phage) clone contig covering the deletion overlap and its flanks is reported, which will prove crucial in the identification of the lung cancer TSG(s).
Functional Characterization of the Candidate Tumor Suppressor Gene NPRL2/G21 Located in 3p21.3C
TLDR
It is confirmed that NPRL2 is a multiple tumor suppressor gene and speculated that the NPRL 2/G21 nuclear protein may be involved in mismatch repair, cell cycle checkpoint signaling, and activation of apoptotic pathway(s).
The candidate tumor suppressor gene, RASSF1A, from human chromosome 3p21.3 is involved in kidney tumorigenesis
TLDR
Data suggest that RASSF1A is the candidate renal TSG gene for the 3p21.3 region, which usually involves any combination of three regions: 3p25-p26 (harboring the VHL gene), 3p12-p14.2 (containing the FHIT gene), and3p21-p22, implying inactivation of the resident tumor-suppressor genes (TSGs).
RBSP3 (HYA22) is a tumor suppressor gene implicated in major epithelial malignancies.
TLDR
This study performs an initial analysis of RBSP3/HYA22, a candidate tumor suppressor genes located in the AP20 region, and identifies two sequence splice variants that belong to a gene family of small C-terminal domain phosphatases that may control the RNA polymerase II transcription machinery.
Genetic and epigenetic analysis of non-small cell lung cancer with NotI-microarrays
TLDR
This study aimed to clarify genetic and epigenetic alterations that occur during lung carcinogenesis and to design perspective sets of newly identified biomarkers to allow early detection, tumor progression, metastases and to discriminate between SCC and ADC with sensitivity and specificity of 80–100%.
Epigenetic analysis of childhood acute lymphoblastic leukemia
TLDR
The methylation of the above 5 genes was cancer specific and expression of the genes could be restored in methylated leukemia cell lines treated with 5-aza-2’-deoxycytidine, the first report demonstrating frequent epigenetic inactivation of PPP2R3A, FBLN2, THRB, BNC1 and MSX1 in leukemia.
Anti-angiogenic and tumor-suppressive roles of candidate tumor-suppressor gene, Fibulin-2, in nasopharyngeal carcinoma
TLDR
Evidence is provided that FBLN2S has an important tumor-suppressive and anti-angiogenic role in NPC and in vivo studies in nude mice show its expression is associated with tumor and angiogenesis suppression.
Inactivation of RASSF1C during in vivo tumor growth identifies it as a tumor suppressor gene
TLDR
The results strongly imply that like RassF1A the RASSF1C gene could serve a tumor suppressor function.
Human cell lines engineered for tetracycline‐regulated expression of tumor suppressor candidate genes from a frequently affected chromosomal region, 3p21
TLDR
New vectors and a unifying strategy to generate tTA‐expressing cell lines are described and described in detail for the intensive use of the tet‐system.
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