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Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over
TLDR
Findings suggest that Mlh1 is involved in DNA mismatch repair and meiotic crossing over in mice deficient in another mismatch repair gene, M lh1.
Mutation in the DNA mismatch repair gene homologue hMLH 1 is associated with hereditary non-polyposis colon cancer
TLDR
It is reported that a human gene encoding a protein, hMLHl (human MutL homologue), homologous to the bacterial DNA mismatch repair protein MutL, is located on human chromosome 3p21.3-23.
Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair
TLDR
It is shown that mutations in any three yeast genes involved in DNA mismatch repair lead to 100- to 700-fold increases in tract instability, whereas mutations that eliminate the proof-reading function of DNA polymerases have little effect.
Mammalian DNA mismatch repair.
TLDR
Genetic studies in cultured mammalian cells and mice are proving to be instrumental in defining the relationship between the functions of MMR in mutation and tumor avoidance, and approaches have raised awareness that MMR homologs contribute to DNA damage surveillance, transcription-coupled repair, and recombinogenic and meiotic processes.
Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair
TLDR
The penultimate sentence in the legend to Table 1 of this letter should read: "The plasmid pSH91 contains an in-frame insertion of poly(GT) (33 bp) in URA3;" not that the plasmids is identical to pSH36 apart from the size of the tract, as originally stated.
Altered expression of hMSH2 and hMLH1 in tumors with microsatellite instability and genetic alterations in mismatch repair genes.
TLDR
Examining the protein expression pattern of hMSH2 and hMLH1 by immunohistochemistry in paraffin-embedded tumors from 7 patients with MIN+ sporadic cancer, 13 patients with familial colorectal cancer, and 12 patients meeting the strict Amsterdam criteria for hereditary nonpolyposis colon cancer suggest that examination of protein expression by immunOHistochemistry may be a rapid method for prescreening tumors for mutations in the MMR genes.
Functional domains of the Saccharomyces cerevisiae Mlh1p and Pms1p DNA mismatch repair proteins and their relevance to human hereditary nonpolyposis colorectal cancer-associated mutations
TLDR
Using site-directed mutagenesis, a number of highly conserved residues in the Mlh1p and Pms1p proteins are altered, including some alterations that mimic germline mutations observed for human hereditary nonpolyposis colorectal cancer.
Dual requirement in yeast DNA mismatch repair for MLH1 and PMS1, two homologs of the bacterial mutL gene.
TLDR
It is suggested that in contrast to Escherichia coli, there are two MutL/HexB-like proteins in S. cerevisiae and that each is a required component of the same DNA mismatch repair pathway.
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