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MLH1 protein, human

Known as: MGC5172, Mismatch Repair Protein MLH1, hMLH1 protein, human 
DNA mismatch repair protein Mlh1 (756 aa, ~85 kDa) is encoded by the human MLH1 gene. This protein is involved in post-replicative DNA mismatch… 
National Institutes of Health

Related topics

Related topics

25 relations
Adenosine TriphosphatasesBreastCell NucleusColon structure (body structure)

Broader (1)

MutL Protein Homolog 1

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
MLH1 deficiency leads to deregulated mitochondrial metabolism
The DNA mismatch repair (MMR) pathway is responsible for the repair of base–base mismatches and insertion/deletion loops that… 
2018
2018
Hypomethylation of mismatch repair genes MLH1 and MSH2 is associated with chemotolerance of breast carcinoma: Clinical significance
The aim of the study was to understand the importance of mismatch repair genes MLH1 and MSH2 in chemotolerance and prognosis of… 
2018
2018
DNA mismatch repair proteins MLH1 and PMS2 can be imported to the nucleus by a classical nuclear import pathway.
2018
2018
The MLH1 ATPase domain is needed for suppressing aberrant formation of interstitial telomeric sequences.
2013
2013
Influence of MLH1 on colon cancer sensitivity to poly(ADP-ribose) polymerase inhibitor combined with irinotecan.
Poly(ADP-ribose) polymerase inhibitors (PARPi) are currently evaluated in clinical trials in combination with topoisomerase I… 
2013
2013
Stable expression of MutLγ in human cells reveals no specific response to mismatched DNA, but distinct recruitment to damage sites
The human DNA mismatch repair (MMR) gene family comprises four MutL paralogues capable of forming heterodimeric MutLα (MLH1‐PMS2… 
2010
2010
Cytoskeletal scaffolding proteins interact with Lynch‐Syndrome associated mismatch repair protein MLH1
The involvement of MLH1 in several mismatch repair‐independent cellular processes has been reported. In an attempt to gain… 
2006
2006
First report of a de novo germline mutation in the MLH1 gene.
Hereditary non-polyposis colorectal carcinoma (HNPCC) is an autosomal dominant disorder associated with colorectal and… 
2006
2006
In vitro analysis of genomic instability triggered by BRCA1 missense mutations
The BRCA1 tumor suppressor gene encodes a phosphoprotein involved in many cellular key functions including DNA repair… 
2003
2003
Pathogenicity of the hereditary colorectal cancer mutation hMLH1 del616 linked to shortage of the functional protein.
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