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Protection of Human Endothelial Cells From Oxidative Stress: Role of Ras-ERK1/2 Signaling
Background—Reactive oxygen species play a critical role in inducing apoptosis. The small GTPase p21 Ras and the ERK1/2 MAPK have been proposed as key regulators of the signaling cascade triggered byExpand
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The B Subunit of the CAAT-binding Factor NFY Binds the Central Segment of the Co-activator p300*
We report that the heterotrimeric transcription factor NFY or “CAAT-binding factor” binds the −60 region of the human H ferritin promoter, the B site. DNA binding analysis with specific antibodiesExpand
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A Common Mechanism Underlying the E1A Repression and the cAMP Stimulation of the H Ferritin Transcription*
Transcription of the H ferritin gene in vivo is stimulated by cAMP and repressed by the E1A oncoprotein. We report here the identification of the cis-element in the human promoter responsive to bothExpand
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p53-mediated downregulation of H ferritin promoter transcriptional efficiency via NF-Y.
The tumor suppressor protein p53 triggers many of the cellular responses to DNA damage by regulating the transcription of a series of downstream target genes. p53 acts on the promoter of the targetExpand
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Effect of stent coating alone on in vitro vascular smooth muscle cell proliferation and apoptosis.
Synthetic polymers, like methacrylate (MA) compounds, have been clinically introduced as inert coatings to locally deliver drugs that inhibit restenosis after stent. The aim of the present study wasExpand
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Transcription factor NF-Y regulates differentiation of CaCo-2 cells.
The CaCo-2 cell line is used to study the molecular mechanisms underlying differentiation of intestinal epithelial cells. These cells undergo a gradual differentiation process that is growth-relatedExpand
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Plasma Proteomic Profiling in Hereditary Breast Cancer Reveals a BRCA1-Specific Signature: Diagnostic and Functional Implications
Background Breast cancer (BC) is a leading cause of death among women. Among the major risk factors, an important role is played by familial history of BC. Germ-line mutations in BRCA1/2 genesExpand
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Sgk1 enhances RANBP1 transcript levels and decreases taxol sensitivity in RKO colon carcinoma cells
The serum- and glucocorticoid-regulated kinase (Sgk1) is essential for hormonal regulation of epithelial sodium channel-mediated sodium transport and is involved in the transduction of growthExpand
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P/CAF/p300 complex binds the promoter for the heavy subunit of ferritin and contributes to its tissue-specific expression.
We analysed the role of the nuclear protein P/CAF in regulating the transcription of the gene for human heavy (H) ferritin in given cell types. P/CAF is a histone acetylase, recruited to specificExpand
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Specific changes in the proteomic pattern produced by the BRCA1-Ser1841Asn missense mutation.
BRCA1 is a nuclear phosphoprotein that plays a key role in many cell functions, including DNA repair, control of transcription, recombination and cell cycle homeostasis. Inherited missense mutationsExpand
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