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Mitogen-Activated Protein Kinase 11

Known as: p38(beta) MAP Kinase, p38beta MAP Kinase, SAP Kinase-2 
A 38-kDa mitogen-activated protein kinase that is expressed in a broad variety of cell types. It may play a role in regulating cell proliferation and… 
National Institutes of Health

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In BloodMAP kinase activityMAPK11 geneMAPK11 wt Allele

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MAPK11 protein, human

Papers overview

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Highly Cited
2012
Highly Cited
2012
A rice orthologue of the ABA receptor, OsPYL/RCAR5, is a positive regulator of the ABA signal transduction pathway in seed germination and early seedling growth.
Abscisic acid (ABA) is a phytohormone that positively regulates seed dormancy and stress tolerance. PYL/RCARs were identified an… 
Highly Cited
2001
Highly Cited
2001
Caspases as key executors of methyl selenium-induced apoptosis (anoikis) of DU-145 prostate cancer cells.
Apoptosis induction may be a mechanism mediating the anticancer activity of selenium. Our earlier work indicated that distinct… 
Highly Cited
2001
Highly Cited
2001
EDG‐1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration
Sphingosine‐1‐phosphate (SPP), formed by sphingosine kinase, is the ligand for EDG‐1, a GPCR important for cell migration and… 
Highly Cited
2000
Highly Cited
2000
Vascular Endothelial Growth Factor (VEGF)-driven Actin-based Motility Is Mediated by VEGFR2 and Requires Concerted Activation of Stress-activated Protein Kinase 2 (SAPK2/p38) and Geldanamycin…
In endothelial cells, vascular endothelial growth factor (VEGF) induces an accumulation of stress fibers associated with new… 
Highly Cited
1999
Highly Cited
1999
Glucose Stimulates Translocation of the Homeodomain Transcription Factor PDX1 from the Cytoplasm to the Nucleus in Pancreatic β-Cells*
One of the mechanisms whereby glucose stimulates insulin gene transcription in pancreatic β-cells involves activation of the… 
Highly Cited
1998
Highly Cited
1998
SAPK2/p38-dependent F-Actin Reorganization Regulates Early Membrane Blebbing during Stress-induced Apoptosis
In endothelial cells, H2O2 induces the rapid formation of focal adhesion complexes at the ventral face of the cells and a major… 
Highly Cited
1998
Highly Cited
1998
Hyperosmolality Causes Growth Arrest of Murine Kidney Cells
Murine kidney cells of the inner medullary collecting duct (mIMCD) were exposed to either isosmotic (300 mosmol/kg) or… 
Highly Cited
1997
Highly Cited
1997
Phosphorylation of microtubule‐associated protein tau by stress‐activated protein kinases
Highly Cited
1997
Highly Cited
1997
Activation of stress‐activated protein kinase‐3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38)
Stress‐activated protein kinase‐3 (SAPK3), a recently described MAP kinase family member with a widespread tissue distribution… 
Highly Cited
1997
Highly Cited
1997
Activation of the novel stress‐activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases
A cDNA was cloned that encodes human stress‐activated protein kinase‐4 (SAPK4), a novel MAP kinase family member whose amino acid… 
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