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MAPK11 wt Allele

Known as: SAPK2B, PRKM11, SAPK2 
Human MAPK11 wild-type allele is located in the vicinity of 22q13.33 and is approximately 7 kb in length. This allele, which encodes mitogen… 
National Institutes of Health

Related topics

Related topics

17 relations
22q13.33Adipocytokine Signaling PathwayCell Cycle ControlMAPK Signaling Pathway

Broader (1)

MAPK11 gene

Papers overview

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Highly Cited
2007
Highly Cited
2007
Chemical Genetics Define the Roles of p38α and p38β in Acute and Chronic Inflammation*
The p38 MAP kinase signal transduction pathway is an important regulator of proinflammatory cytokine production and inflammation… 
Highly Cited
2005
Highly Cited
2005
Generation and Characterization of p38β (MAPK11) Gene-Targeted Mice
ABSTRACT p38 mitogen-activated protein kinases (MAPKs) are activated primarily in response to inflammatory cytokines and cellular… 
Highly Cited
2005
Highly Cited
2005
Spinal p38β isoform mediates tissue injury‐induced hyperalgesia and spinal sensitization
Antagonist studies show that spinal p38 mitogen‐activated protein kinase plays a crucial role in spinal sensitization. However… 
Highly Cited
2003
Highly Cited
2003
p38 Isoforms Have Opposite Effects on AP-1-dependent Transcription through Regulation of c-Jun
p38 MAPK pathway signaling is known to participate in cell proliferation, apoptosis, and differentiation, in a manner dependent… 
Highly Cited
1999
Highly Cited
1999
Differential expression and activation of p38 mitogen-activated protein kinase alpha, beta, gamma, and delta in inflammatory cell lineages.
Four p38 mitogen-activated protein kinases (p38alpha, beta, gamma, delta) have been described. To understand the role of p38… 
Highly Cited
1999
Highly Cited
1999
p38 Mitogen-Activated Protein Kinase Can Be Involved in Transforming Growth Factor β Superfamily Signal Transduction in Drosophila Wing Morphogenesis
ABSTRACT p38 mitogen-activated protein kinase (p38) has been extensively studied as a stress-responsive kinase, but its role in… 
Highly Cited
1998
Highly Cited
1998
PRAK, a novel protein kinase regulated by the p38 MAP kinase
We have identified and cloned a novel serine/ threonine kinase, p38‐regulated/activated protein kinase (PRAK). PRAK is a 471… 
Highly Cited
1998
Highly Cited
1998
Hyperosmolality Causes Growth Arrest of Murine Kidney Cells
Murine kidney cells of the inner medullary collecting duct (mIMCD) were exposed to either isosmotic (300 mosmol/kg) or… 
Highly Cited
1997
Highly Cited
1997
Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles.
A novel homologue of p38 MAP kinase, called SAPK4, has been cloned which shares 61% amino acid identity with p38 and is expressed… 
Highly Cited
1996
Highly Cited
1996
Characterization of the Structure and Function of a New Mitogen-activated Protein Kinase (p38β)*
Mitogen-activated protein (MAP) kinase cascades represent one of the major signal systems used by eukaryotic cells to transduce… 
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