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Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
A set of guidelines for the selection and interpretation of the methods that can be used by investigators who are attempting to examine macroautophagy and related processes, as well as by reviewers who need to provide realistic and reasonable critiques of papers that investigate these processes are presented. Expand
Bax directly induces release of cytochrome c from isolated mitochondria.
It is shown that addition of submicromolar amounts of recombinant Bax protein to isolated mitochondria can induce cytochrome c (Cyt c) release, whereas a peptide representing the Bax BH3 domain was inactive, implying that Bax uses an alternative mechanism for triggering release of Cyt c from mitochondria. Expand
An alternative, nonapoptotic form of programmed cell death.
It is shown that this form of programmed cell death is driven by an alternative caspase-9 activity that is Apaf-1-independent, and should lead to new insight into cell death programs and their roles in development and degeneration. Expand
Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species.
The proto-oncogene bcl-2 inhibits apoptotic and necrotic neural cell death. Expression of Bcl-2 in the GT1-7 neural cell line prevented death as a result of glutathione depletion. IntracellularExpand
Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease
It is shown that long-term inhibition of mTOR by rapamycin prevented AD-like cognitive deficits and lowered levels of Aβ42, a major toxic species in AD, in the PDAPP transgenic mouse model. Expand
Essential versus accessory aspects of cell death: recommendations of the NCCD 2015
The Nomenclature Committee on Cell Death formulates a set of recommendations to help scientists and researchers to discriminate between essential and accessory aspects of cell death. Expand
Neurological manifestations of the acquired immunodeficiency syndrome (AIDS): experience at UCSF and review of the literature.
In light of the protean behavior of AIDS and the problems related to the clinical, radiological, and serological diagnosis of the unusual and varied associated nervous system diseases, patients with AIDS and neurological complaints require a rigorous and detailed evaluation. Expand
Coupling endoplasmic reticulum stress to the cell death program
It is hoped that dissection of the molecular components and pathways that alter ER structure and function and ultimately promote cellular death will provide a framework for understanding degenerative disorders that feature misfolded proteins. Expand
Evidence that 4-Hydroxynonenal Mediates Oxidative Stress-Induced Neuronal Apoptosis
Evidence is provided that 4-hydroxynonenal (HNE), an aldehydic product of membrane lipid peroxidation, is a key mediator of neuronal apoptosis induced by oxidative stress and that the antiapoptotic action of glutathione may involve detoxification of HNE. Expand
Anti-cancer activity of targeted pro-apoptotic peptides
Short peptides composed of two functional domains, one a tumor blood vessel 'homing' motif and the other a programmed cell death-inducing sequence, are designed and synthesized by simple peptide chemistry and may yield new therapeutic agents. Expand