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Activators and target genes of Rel/NF-kappaB transcription factors.
TLDR
It is argued that NF-kappaB functions more generally as a central regulator of stress responses and pairing stress responsiveness and anti-apoptotic pathways through the use of a common transcription factor may result in increased cell survival following stress insults.
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Activators and target genes of Rel/NF-κB transcription factors
  • H. Pahl
  • Biology
    Oncogene
  • 22 November 1999
TLDR
It is argued that NF-κB functions more generally as a central regulator of stress responses and pairing stress responsiveness and anti-apoptotic pathways through the use of a common transcription factor may result in increased cell survival following stress insults.
View on Springer
Phosphorylation of human I kappa B‐alpha on serines 32 and 36 controls I kappa B‐alpha proteolysis and NF‐kappa B activation in response to diverse stimuli.
TLDR
The data suggest that such diverse stimuli as OA, TNF and PMA use the same kinase system to phosphorylate and thereby destabilize I kappa B‐alpha, leading to NF‐kappa B activation.
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MyD88, an Adapter Protein Involved in Interleukin-1 Signaling*
TLDR
A role for MyD88 as an adapter in IL-1 signal transduction is supported; MyD 88 forms homodimers in vivo through DD-DD and Toll-Toll interactions.
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Cysteine 38 in p65/NF-κB Plays a Crucial Role in DNA Binding Inhibition by Sesquiterpene Lactones*
TLDR
Contrary to previous reports, it is shown that parthenolide, like other SLs, inhibits NF-κB most probably by alkylating p65 at Cys38, and the amount of remaining IκB was too low to explain the observed NF-β degradation inhibition.
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The Anti-inflammatory Sesquiterpene Lactone Helenalin Inhibits the Transcription Factor NF-κB by Directly Targeting p65*
TLDR
This sesquiterpene lactone helenalin is the first anti-inflammatory agent shown to exert its effect by directly modifying NF-κB, the central mediator of the human immune response.
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The proto-oncogene PU.1 regulates expression of the myeloid-specific CD11b promoter.
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JAK2 haplotype is a major risk factor for the development of myeloproliferative neoplasms
TLDR
It is reported here that JAK2V617F-associated disease is strongly associated with a specific constitutional Jak2 haplotype, designated 46/1, in all three disease entities compared to healthy controls and provides a model whereby a constitutional genetic factor is associated with an increased risk of acquiring a specific somatic mutation.
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A novel signal transduction pathway from the endoplasmic reticulum to the nucleus is mediated by transcription factor NF‐kappa B.
TLDR
It is shown that internal stress, caused by the accumulation of proteins in the endoplasmic reticulum, also induces NF‐kappa B DNA binding as well as kappa B‐dependent gene expression and participates in a novel ER‐nuclear signal transduction pathway distinct from the unfolded‐protein‐response described previously.
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The immunosuppressive fungal metabolite gliotoxin specifically inhibits transcription factor NF-kappaB
TLDR
It is reported that nanomolar concentrations of gliotoxin inhibited the activation of transcription factor NF-kappaB in response to a variety of stimuli in T and B cells, raising the possibility that the immunosuppression observed during aspergillosis results in part from gliot toxin-mediated NF- kappaB inhibition.
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