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Methysergide

Known as: Metisergido, Methysergide [Chemical/Ingredient], methylsergide 
An ergot derivative that is a congener of LYSERGIC ACID DIETHYLAMIDE. It antagonizes the effects of serotonin in blood vessels and gastrointestinal… Expand
National Institutes of Health

Related topics

Related topics

30 relations
1-methyllysergic acid butanolamideArteriosclerosisAzolesBacterial Infections
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Broader (4)

ErgolinesSerotonin AntagonistsSerotonin Uptake InhibitorsVasoconstrictor Agents

Narrower (3)

Methysergide MaleateSansertUML-491

Papers overview

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Highly Cited
2006
Highly Cited
2006
Suppression of cortical spreading depression in migraine prophylaxis.
OBJECTIVE Topiramate, valproate, propranolol, amitriptyline, and methysergide have been widely prescribed for migraine… Expand
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Highly Cited
2006
Highly Cited
2006
EFNS guidelines on the treatment of cluster headache and other trigeminal-autonomic cephalalgias.
Cluster headache and the other trigeminal-autonomic cephalalgias [paroxysmal hemicrania, short-lasting unilateral neuralgiform… Expand
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Highly Cited
2000
Highly Cited
2000
Evidence for Possible Involvement of 5-HT2B Receptors in the Cardiac Valvulopathy Associated With Fenfluramine and Other Serotonergic Medications
Background—Serotonergic medications with various mechanisms of action are used to treat psychiatric disorders and are being… Expand
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Highly Cited
2000
Highly Cited
2000
Possible role of valvular serotonin 5-HT(2B) receptors in the cardiopathy associated with fenfluramine.
Dexfenfluramine was approved in the United States for long-term use as an appetite suppressant until it was reported to be… Expand
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Highly Cited
1996
Highly Cited
1996
Hypoxia-induced long-term facilitation of respiratory activity is serotonin dependent.
Repeated isocapnic hypoxia evokes long-term facilitation (LTF) of phrenic nerve activity in rats. We wished to determine: (1… Expand
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Highly Cited
1995
Highly Cited
1995
Intrathecal Amitriptyline Acts as an N‐Methyl‐D‐Aspartate Receptor Antagonist in the Presence of Inflammatory Hyperalgesia in Rats
Background Amitriptyline and other tricyclic antidepressants exhibit high affinity binding to N‐methyl‐D‐aspartate (NMDA… Expand
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Highly Cited
1989
Highly Cited
1989
Behavioral and autonomic correlates of the tactile evoked allodynia produced by spinal glycine inhibition: effects of modulatory receptor systems and excitatory amino acid antagonists
&NA; Intrathecal administration of glycine (strychnine) or GABA (bicuculline) but not opioid (naloxone), adrenergic (phentolamine… Expand
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Highly Cited
1979
Highly Cited
1979
Substance P as neurogenic mediator of antidromic vasodilation and neurogenic plasma extravasation
Summary1.Antidromic vasodilation and neurogenic plasma extravasation were induced by antidromic stimulation of the saphenous… Expand
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Highly Cited
1971
Highly Cited
1971
Mediators of the inflammation induced in the rat paw by carrageenin.
1. The time course of oedema formation in rats caused by injection of carrageenin into the paw was followed for 5.5 hours. Intact… Expand
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Highly Cited
1966
Highly Cited
1966
Fibrotic disorders associated with methysergide therapy for headache.
THE development of retroperitoneal fibrosis in 27 patients using methysergide for the prevention of headache is the occasion for… Expand
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