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Methylnitrosourea

Known as: methylnitrosourea (MNU), NMH, N Methyl N nitrosourea 
A pale yellow, crystalline nitrosourea that is sensitive to light and moisture and emits toxic fumes of nitrogen oxides when heated to decomposition… 
National Institutes of Health

Related topics

Related topics

13 relations

Narrower (6)

ADEKON,N'-dimethylnitrosoureaN-trimethylsilylmethyl-N-nitrosoureaNSC-23909

Broader (3)

Alkylating AgentsCarcinogensNitrosourea Compounds
analogs & derivativesaspects of radiation effectschemical synthesisstandards characteristics

Papers overview

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Highly Cited
1983
Highly Cited
1983
Organ-specific promoting effect of phenobarbital and saccharin in induction of thyroid, liver, and urinary bladder tumors in rats after initiation with N-nitrosomethylurea.
Tumor-promoting effects of phenobarbital (PB) and sodium saccharin (SS) were tested in rats pretreated with N-nitrosomethylurea… 
Highly Cited
1982
Highly Cited
1982
Enhanced inhibition of mammary carcinogenesis by combined treatment with N-(4-hydroxyphenyl)retinamide and ovariectomy.
Bilateral ovariectomy and dietary administration of the retinoid N-(4-hydroxyphenyl)retinamide (4-HPR) are both effective… 
Highly Cited
1982
Highly Cited
1982
Potent mutagenic activity of nitropyrenes on Chinese hamster lung cells with diphtheria toxin resistance as a selective marker.
Nitropyrenes, which are highly mutagenic in the Salmonella assay, were shown also to be potent mutagens on Chinese hamster lung… 
Highly Cited
1981
Highly Cited
1981
Effect of combined selenium and retinyl acetate treatment on mammary carcinogenesis.
The influence of feeding a pharmacological level of either selenium (SE), retinyl acetate (RA), or selenium and retinyl acetate… 
Highly Cited
1981
Highly Cited
1981
Time course of O6-methylguanine removal from DNA of N-methyl-N-nitrosourea-treatedhuman fibroblasts
Methylating mutagens are thought to act by induction of direct miscoding, mainly through formation of O6-methylguanine (O6MeG) in… 
Highly Cited
1978
Highly Cited
1978
Alkylation of deoxyribonucleic acid by carcinogens dimethyl sulphate, ethyl methanesulphonate, N-ethyl-N-nitrosourea and N-methyl-N-nitrosourea. Relative reactivity of the phosphodiester site…
1. The ethyl phosphotriester of thymidylyl(3'-5')thymidine, dTp(Et)dT, was identified as a product from reaction of DNA with N… 
Highly Cited
1978
Highly Cited
1978
Mechanisms of inhibition by ascorbate of microbial mutagenesis induced by N-nitroso compounds.
Mutagenesis induced by N-methyl-N-nitrosoguanidine (MNNG) and dimethylnitrosamine (DMN) in Salmonella TA 1530 was inhibited by… 
Highly Cited
1977
Highly Cited
1977
Separative pathways for urea and water, and for chloride in chicken erythrocytes.
1. Urea and water permeabilities of chicken erythrocytes are considerably lower than those of mammalian red cells. 2. The… 
Highly Cited
1975
Highly Cited
1975
Isolation and identification of products from alkylation of nucleic acids: ethyl- and isopropyl-purines.
Ethylation and isopropylation of guanine in alkaline solution, or of adenine in formic acid, by alkyl methanesulphonates gave the… 
Highly Cited
1975
Highly Cited
1975
2-chloroethanol formation as evidence for a 2-chloroethyl alkylating intermediate during chemical degradation of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea and 1-(2-chloroethyl)-3-(trans-4…
Chemical degradation of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea or 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1…