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Nitrosourea Compounds

Known as: nitrosureas, Nitrosourea Compound, nitrosurea 
Any of a class of alkylating agents that contain both a nitroso group and a urea. They are lipophilic and can cross the blood-brain barrier.
National Institutes of Health

Related topics

Related topics

44 relations

Narrower (34)

1,1-ethylenebis(1-nitrosourea)1,3-dibutyl-1-nitrosourea1-amyl-1-nitrosoureaB 3839

Broader (3)

Alkylating AgentsNitroso CompoundsUrea
In BloodLomustineagonistsantagonists & inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
Development of an in vivo gene mutation assay using the endogenous Pig‐A gene: I. Flow cytometric detection of CD59‐negative peripheral red blood cells and CD48‐negative spleen T‐cells from the rat
The product of the phosphatidylinositol glycan complementation group A gene (Pig‐A) is involved in the synthesis of… 
Review
1998
Review
1998
Mouse mutagenesis-systematic studies of mammalian gene function.
The mouse will play a pivotal role in mammalian gene function studies as we enter the post-genomics era. The challenge is to… 
Highly Cited
1997
Highly Cited
1997
Allium cepa anaphase-telophase root tip chromosome aberration assay on N-methyl-N-nitrosourea, maleic hydrazide, sodium azide, and ethyl methanesulfonate.
Highly Cited
1996
Highly Cited
1996
Gene interaction and single gene effects in colon tumour susceptibility in mice
To dissect the multigenic control of colon tumour susceptibility in the mouse1 we used the set of 20 CcS/Dem (CcS) recombinant… 
Review
1987
Review
1987
Activated neu oncogene sequences in primary tumors of the peripheral nervous system induced in rats by transplacental exposure to ethylnitrosourea.
Neurogenic tumors were selectively induced in high incidence in F344 rats by a single transplacental exposure to the direct… 
Highly Cited
1982
Highly Cited
1982
Induction of mutations and sister-chromatid exchanges in Chinese hamster ovary cells by ethylating agents.
Highly Cited
1980
Highly Cited
1980
The enhancement of cytotoxicity of N-methyl-N-nitrosourea and of gamma-radiation by inhibitors of poly(ADP-ribose) polymerase.
Inhibitors of poly(ADP-ribose) polymerase show a synergistic potentiation of cytotoxicity with certain DNA-damaging agents. Non… 
Highly Cited
1977
Highly Cited
1977
Chemotherapy of human colon cancer xenografts in athymic nude mice
The lack of effective chemotherapy in advanced colon cancer and difficulties in evaluating response in clinical trials indicate a… 
Review
1975
Review
1975
Clinical comparison of the nitrosoureas
The nitrosourea group of antitumor agents was developed by the Division of Cancer Treatment of the National Cancer Institute… 
Highly Cited
1971
Highly Cited
1971
Quantitative aspects of the repair of alkylated DNA in cultured mammalian cells. II. Non-semiconservative DNA synthesis ('repair synthesis') in HeLa and Chinese hamster cells following treatment with…
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