Nitrosourea Compounds

Intracellular lipopolysaccharide from Gram-negative bacteria including Escherichia coli, Salmonella typhimurium, Shigella… Expand

Classical genetic methods, driven by phenotype rather than hypotheses, generally permit the identification of all proteins that… Expand

Here we have identified 'triple D' (3d), a recessive N-ethyl-N-nitrosourea-induced mutation and phenotype in which no signaling… Expand

Toll-like receptor 2 (TLR2) is required for the recognition of numerous molecular components of bacteria, fungi and protozoa. The… Expand

The recessive mutation 'Heedless' (hdl) was detected in third-generation N-ethyl-N-nitrosourea–mutated mice that showed defective… Expand

Several subsets of dendritic cells have been shown to produce type I IFN in response to viral infections, thereby assisting the… Expand

Poly(ADP-ribose) polymerase [PARP; NAD+ ADP-ribosyltransferase; NAD+: poly(adenosine-diphosphate-D-ribosyl)-acceptor ADP-D… Expand

Systematic genome-wide mutagenesis screens for embryonic phenotypes have been instrumental in the understanding of invertebrate… Expand

In a search for genes that regulate circadian rhythms in mammals, the progeny of mice treated with N-ethyl-N-nitrosourea (ENU… Expand

Within three weeks of definitive surgical intervention, 467 patients with histologically proved malignant glioma were randomized… Expand