Nitrosourea Compounds

Known as: nitrosureas, Nitrosourea Compound, nitrosurea 
Any of a class of alkylating agents that contain both a nitroso group and a urea. They are lipophilic and can cross the blood-brain barrier.
National Institutes of Health

Related topics

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43 relations

Narrower (33)

1,1-ethylenebis(1-nitrosourea)1,3-dibutyl-1-nitrosourea1-amyl-1-nitrosoureaB 3839
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Broader (3)

Alkylating AgentsNitroso CompoundsUrea
In BloodLomustineagonistsantagonists & inhibitors
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Papers overview

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Highly Cited
2007
Highly Cited
2007
The after-hours mutant reveals a role for Fbxl3 in determining mammalian circadian period.
By screening N-ethyl-N-nitrosourea-mutagenized animals for alterations in rhythms of wheel-running activity, we identified a… (More)
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Highly Cited
2006
Highly Cited
2006
Comparison of imatinib mesylate, dasatinib (BMS-354825), and nilotinib (AMN107) in an N-ethyl-N-nitrosourea (ENU)-based mutagenesis screen: high efficacy of drug combinations.
BMS-354825 (dasatinib) and AMN107 (nilotinib) are potent alternate Abl inhibitors with activity against many imatinib mesylate… (More)
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Highly Cited
2003
Highly Cited
2003
Identification of Lps2 as a key transducer of MyD88-independent TIR signalling
In humans, ten Toll-like receptor (TLR) paralogues sense molecular components of microbes, initiating the production of cytokine… (More)
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Highly Cited
2002
Highly Cited
2002
Target-selected inactivation of the zebrafish rag1 gene.
The zebrafish has become a favorite organism for genetic analysis of vertebrate development, but methods for generating mutants… (More)
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Highly Cited
2001
Highly Cited
2001
AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations.
The t(8;21) is one of the most frequent chromosomal abnormalities associated with acute myeloid leukemia (AML). The translocation… (More)
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Highly Cited
1997
Highly Cited
1997
Monitoring early response of experimental brain tumors to therapy using diffusion magnetic resonance imaging.
Quantitative magnetic resonance imaging was performed to evaluate water diffusion and relaxation times, T1 and T2, as potential… (More)
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Highly Cited
1996
Highly Cited
1996
A genetic screen for mutations affecting embryogenesis in zebrafish.
Systematic genome-wide mutagenesis screens for embryonic phenotypes have been instrumental in the understanding of invertebrate… (More)
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Highly Cited
1994
Highly Cited
1994
Efficient recovery of ENU-induced mutations from the zebrafish germline.
We studied the efficiency with which two chemical mutagens, ethyl methanesulfonate (EMS) and N-ethyl-N-nitrosourea (ENU) can… (More)
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Highly Cited
1990
Highly Cited
1990
The treatment of medulloblastoma. Results of a prospective randomized trial of radiation therapy with and without CCNU, vincristine, and prednisone.
In a prospective randomized trial designed to study the effectiveness of adjuvant chemotherapy following standard surgical… (More)
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Highly Cited
1980
Highly Cited
1980
Randomized comparisons of radiotherapy and nitrosoureas for the treatment of malignant glioma after surgery.
Within three weeks of definitive surgical intervention, 467 patients with histologically proved malignant glioma were randomized… (More)
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