Methyl Group

A small molecule made of one carbon and three hydrogen atoms. Methyl groups are added or removed from proteins or nucleic acids and may change the… (More)
National Institutes of Health

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Highly Cited
2013
Highly Cited
2013
Bardoxolone methyl in type 2 diabetes and stage 4 chronic kidney disease.
BACKGROUND Although inhibitors of the renin-angiotensin-aldosterone system can slow the progression of diabetic kidney disease… (More)
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Highly Cited
2011
Highly Cited
2011
TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity
Enzymes catalysing the methylation of the 5-position of cytosine (mC) have essential roles in regulating gene expression and… (More)
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Review
2010
Review
2010
The clinical significance of betaine, an osmolyte with a key role in methyl group metabolism.
Betaine is an essential osmolyte and source of methyl groups and comes from either the diet or by the oxidation of choline. Its… (More)
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Review
2009
Review
2009
Protein arginine methylation in mammals: who, what, and why.
The covalent marking of proteins by methyl group addition to arginine residues can promote their recognition by binding partners… (More)
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Highly Cited
2006
Highly Cited
2006
HEN1 recognizes 21–24 nt small RNA duplexes and deposits a methyl group onto the 2′ OH of the 3′ terminal nucleotide
microRNAs (miRNAs) and small interfering RNAs (siRNAs) in plants bear a methyl group on the ribose of the 3' terminal nucleotide… (More)
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Highly Cited
2005
Highly Cited
2005
Methylation Protects miRNAs and siRNAs from a 3′-End Uridylation Activity in Arabidopsis
Small RNAs of 21-25 nucleotides (nt), including small interfering RNAs (siRNAs) and microRNAs (miRNAs), act as guide RNAs to… (More)
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Highly Cited
2002
Highly Cited
2002
Germ-line variants in methyl-group metabolism genes and susceptibility to DNA methylation in normal tissues and human primary tumors.
Aberrant DNA methylation is recognized as being a common feature of human neoplasia.CpG island hypermethylation and global… (More)
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Review
1996
Review
1996
S-Adenosylmethionine and methylation.
S-Adenosylmethionine (AdoMet or SAM) plays a pivotal role as a methyl donor in a myriad of biological and biochemical events… (More)
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Highly Cited
1985
Highly Cited
1985
A computational procedure for determining energetically favorable binding sites on biologically important macromolecules.
The interaction of a probe group with a protein of known structure is computed at sample positions throughout and around the… (More)
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Highly Cited
1982
Highly Cited
1982
Nonenzymatic methylation of DNA by the intracellular methyl group donor S-adenosyl-L-methionine is a potentially mutagenic reaction.
Incubation of DNA with S-adenosyl-L-methionine (SAM) in neutral aqueous solution leads to base modification, with formation of… (More)
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