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- Publications
- Influence
Steroid 5 alpha-reductase: two genes/two enzymes.
- D. Russell, J. Wilson
- Chemistry, Medicine
- Annual review of biochemistry
- 1994
BIOCHEMICAL PROPERTIES OF STEROID Sa-REDUCTASE . . . . . . . . . . . . 30 Protein Structure . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . 30 pH Optima . . . . . . . .… Expand
Male pseudohermaphroditism caused by mutations of testicular 17β–hydroxysteroid dehydrogenase 3
- W. Geissler, Daphne L. Davis, +7 authors S. Andersson
- Biology, Medicine
- Nature Genetics
- 1 May 1994
Defects in the conversion of androstenedione to testosterone in the fetal testes by the enzyme 17β–hydroxysteroid dehydrogenase (17β–HSD) give rise to genetic males with female external genitalia. We… Expand
Steroid 5 alpha-reductase 2 deficiency.
- J. Wilson, J. Griffin, D. Russell
- Biology, Medicine
- Endocrine reviews
- 1 October 1993
In the 20 yr since it was established that impairment of dihydrotestosterone formation is the cause of a rare form of human intersex, a wealth of information has accumulated about the genetics,… Expand
Androgen abuse by athletes.
- J. Wilson
- Medicine
- Endocrine reviews
- 1 May 1988
Introduction ANDROGEN abuse by athletes constitutes only a portion of the problem of androgen misuse by the general population (1) and only a minor aspect of the doping of athletes with drugs… Expand
Mechanisms of neovascularization. Vascular sprouting can occur without proliferation of endothelial cells.
- M. Sholley, G. Ferguson, H. Seibel, J. Montour, J. Wilson
- Medicine
- Laboratory investigation; a journal of technical…
- 1984
The kinetics of endothelial cells during microvascular growth were studied using a model of inflammation-induced neovascularization of the rat cornea. Inflammation was produced by central silver… Expand
Molecular genetics of steroid 5 alpha-reductase 2 deficiency.
- A. Thigpen, Daphne L. Davis, +6 authors D. Russell
- Biology, Medicine
- The Journal of clinical investigation
- 1 September 1992
Two isozymes of steroid 5 alpha-reductase encoded by separate loci catalyze the conversion of testosterone to dihydrotestosterone. Inherited defects in the type 2 isozyme lead to male… Expand
Testosterone formation and metabolism during male sexual differentiation in the human embryo.
- P. Siiteri, J. Wilson
- Biology, Medicine
- The Journal of clinical endocrinology and…
- 1974
ABSTRACT The formation by the gonads of [3H] testosterone from [7α-3H]pregnenolone and [1,2-3H] progesterone and the metabolism of [1,2-3H]testosterone by various tissues have been studied in 33… Expand
Characterization and expression of a cDNA encoding the human androgen receptor.
- W. Tilley, M. Marcelli, J. Wilson, M. J. McPhaul
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 1989
We report the isolation of a cDNA that encodes the complete human androgen receptor. The cDNA predicts a protein of 917 amino acids with a molecular weight of 98,918. Introduction of the cDNA into… Expand
Testosterone at high concentrations interacts with the human androgen receptor similarly to dihydrotestosterone.
- P. Grino, J. Griffin, J. Wilson
- Chemistry, Medicine
- Endocrinology
- 1 February 1990
Testosterone and dihydrotestosterone are believed to exert their androgenic effects by interacting with a single intracellular receptor protein in androgen target tissues. During fetal life, however,… Expand
Familial incomplete male pseudohermaphroditism, type 2. Decreased dihydrotestosterone formation in pseudovaginal perineoscrotal hypospadias.
- P. Walsh, J. Madden, M. E. Harrod, J. Goldstein, P. Macdonald, J. Wilson
- Biology, Medicine
- The New England journal of medicine
- 31 October 1974
Abstract Two 46 XY siblings with familial incomplete male pseudohermaphroditism, Type 2, inherited as an apparent autosomal recessive trait, were investigated. The phenotype was distinctive in that… Expand