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Steroid 5 alpha-reductase: two genes/two enzymes.
BIOCHEMICAL PROPERTIES OF STEROID Sa-REDUCTASE . . . . . . . . . . . . 30 Protein Structure . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . 30 pH Optima . . . . . . . .Expand
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Male pseudohermaphroditism caused by mutations of testicular 17β–hydroxysteroid dehydrogenase 3
Defects in the conversion of androstenedione to testosterone in the fetal testes by the enzyme 17β–hydroxysteroid dehydrogenase (17β–HSD) give rise to genetic males with female external genitalia. WeExpand
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Steroid 5 alpha-reductase 2 deficiency.
In the 20 yr since it was established that impairment of dihydrotestosterone formation is the cause of a rare form of human intersex, a wealth of information has accumulated about the genetics,Expand
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Androgen abuse by athletes.
Introduction ANDROGEN abuse by athletes constitutes only a portion of the problem of androgen misuse by the general population (1) and only a minor aspect of the doping of athletes with drugsExpand
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Mechanisms of neovascularization. Vascular sprouting can occur without proliferation of endothelial cells.
The kinetics of endothelial cells during microvascular growth were studied using a model of inflammation-induced neovascularization of the rat cornea. Inflammation was produced by central silverExpand
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Molecular genetics of steroid 5 alpha-reductase 2 deficiency.
Two isozymes of steroid 5 alpha-reductase encoded by separate loci catalyze the conversion of testosterone to dihydrotestosterone. Inherited defects in the type 2 isozyme lead to maleExpand
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Testosterone formation and metabolism during male sexual differentiation in the human embryo.
ABSTRACT The formation by the gonads of [3H] testosterone from [7α-3H]pregnenolone and [1,2-3H] progesterone and the metabolism of [1,2-3H]testosterone by various tissues have been studied in 33Expand
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Characterization and expression of a cDNA encoding the human androgen receptor.
We report the isolation of a cDNA that encodes the complete human androgen receptor. The cDNA predicts a protein of 917 amino acids with a molecular weight of 98,918. Introduction of the cDNA intoExpand
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Testosterone at high concentrations interacts with the human androgen receptor similarly to dihydrotestosterone.
Testosterone and dihydrotestosterone are believed to exert their androgenic effects by interacting with a single intracellular receptor protein in androgen target tissues. During fetal life, however,Expand
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Familial incomplete male pseudohermaphroditism, type 2. Decreased dihydrotestosterone formation in pseudovaginal perineoscrotal hypospadias.
Abstract Two 46 XY siblings with familial incomplete male pseudohermaphroditism, Type 2, inherited as an apparent autosomal recessive trait, were investigated. The phenotype was distinctive in thatExpand
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