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Methionine gamma-lyase

Known as: L-methionine alpha-deamino gamma-mercaptomethane-lyase, L-methioninase, L-methionine gamma-lyase 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

Antimetabolites, AntineoplasticCarbon-Sulfur Lyases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Efficacy of oral recombinant methioninase combined with oxaliplatinum and 5-fluorouracil on primary colon cancer in a patient-derived orthotopic xenograft mouse model.
2017
2017
Recombinant methioninase (rMETase) is an effective therapeutic for BRAF-V600E-negative as well as -positive melanoma in patient-derived orthotopic xenograft (PDOX) mouse models
Melanoma is a recalcitrant disease. Melanoma patients with the BRAF-V600E mutation have been treated with the drug vemurafenib… 
2006
2006
Enhanced 7-Ethyl-10-hydroxycamptothecin (SN-38) Lethality by Methylselenocysteine Is Associated with Chk2 Phosphorylation at Threonine-68 and Down-Regulation of Cdc6 Expression
Methylselenocysteine (MSC) is an organic selenium compound in preventative clinical trials involving prostate, lung, and colon… 
2003
2003
Methioninase gene therapy with selenomethionine induces apoptosis in bcl-2-overproducing lung cancer cells
We have previously shown that the toxic pro-oxidant methylselenol is released from selenomethionine (SeMET) by cancer cells… 
Review
1997
Review
1997
Methioninase: a therapeutic for diseases related to altered methionine metabolism and transmethylation: cancer, heart disease, obesity, aging, and Parkinson's disease.
Methionine metabolism and transmethylation are central to the metabolism and differentiation of all known cells. In enkaryotic… 
Review
1997
Review
1997
Methioninase: a therapeutic for diseases related to altered methionine metabolism and transmethylation: cancer, heart disease, obesity, aging, and Parkinson's disease.
: Methionine metabolism and transmethylation are central to the metabolism and differentiation of all known cells. In enkaryotic… 
1993
1993
Depletion of serum methionine by methioninase in mice.
Methionine dependence is a tumor-specific metabolic defect found in human cancer cell lines as well as in fresh human tumor… 
Review
1979
Review
1979
Nutrients, vitamins and minerals as therapy
Nutrients as therapy for patients with cancer are important as adjunctive therapy, i.e., adequate nutrition may be important for… 
Highly Cited
1976
Highly Cited
1976
Purification and properties of methioninase from Pseudomonas ovalis
1951
1951
The role of pyridoxal in methylmercaptan formation, partial purification and resolution of methioninase.
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