Metallothionein

Known as: Metallothionein [Chemical/Ingredient], Metallothioneins 
A low-molecular-weight (approx. 10 kD) protein occurring in the cytoplasm of kidney cortex and liver. It is rich in cysteinyl residues and contains… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1966-2018
020040019662018

Papers overview

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Highly Cited
2006
Highly Cited
2006
OBJECTIVES We aimed to test whether attenuation of early-phase cardiac cell death can prevent diabetic cardiomyopathy… (More)
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Highly Cited
2005
Highly Cited
2005
The mechanisms of metallothionein prevention of diabetic cardiomyopathy are largely unknown. The present study was performed to… (More)
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Highly Cited
2004
Highly Cited
2004
Skeletal muscle atrophy is a debilitating response to starvation and many systemic diseases including diabetes, cancer, and renal… (More)
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Highly Cited
2000
Highly Cited
2000
The metallothioneins (MT) are small, cysteine-rich heavy metal-binding proteins which participate in an array of protective… (More)
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Highly Cited
1998
Highly Cited
1998
We postulate a novel and general mechanism in which the redox-active sulfur donor group of cyst(e)ine confers oxidoreductive… (More)
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Highly Cited
1998
Highly Cited
1998
Metallothionein (MT), despite its high metal binding constant (KZn = 3.2 x 10(13) M-1 at pH 7.4), can transfer zinc to the… (More)
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Highly Cited
1988
Highly Cited
1988
Resistance to antineoplastic agents is the major obstacle to curative therapy of cancer. Tumor cell lines with acquired… (More)
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Highly Cited
1988
Highly Cited
1988
The promoter from the metallothionein gene may be a useful conditional promoter for the construction of chimeric genes to be… (More)
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Highly Cited
1985
Highly Cited
1985
Rabbit liver metallothionein-1 (Mr 6500), which contains zinc and/or cadmium ions, appears to scavenge free hydroxyl (.OH) and… (More)
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Highly Cited
1982
Highly Cited
1982
A DNA fragment containing the promoter of the mouse metallothionein-I gene fused to the structural gene of rat growth hormone was… (More)
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