Transcriptional regulation of mouse liver metallothionein-I gene by glucocorticoids

  title={Transcriptional regulation of mouse liver metallothionein-I gene by glucocorticoids},
  author={Lisa J. Hager and Richard D Palmiter},
Glucocorticoid hormones play an important part in the regulation of many essential metabolic processes1. These include the synthesis of stress-related ‘acute-phase’ proteins2 and the timing of developmental events in numerous tissues including fetal lung, liver and intestine, and adult mammary gland1. Among the proteins that are induced by glucocorticoids during stress and fetal development are the metallothioneins (MT)3–6. These small, cysteine-rich proteins are found primarily in the liver… CONTINUE READING

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