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Megestrol Acetate
Known as:
6-Methyl-delta-4,6-pregnadien-17 alpha-ol-3,20-dione Acetate
, 17alpha-Hydroxy-6-methylpregna-4,6-diene-3,20-dione acetate
, 17?-Hydroxy-6-methylpregna-4,6-diene-3,20-dione acetate
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The acetate salt form of megestrol, a synthetic derivative of the naturally occurring female sex hormone progesterone with potential anti-estrogenic…
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National Institutes of Health
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Related topics
Related topics
28 relations
Anorexia
Cachexia
Drug Allergy
Endometrial Neoplasms
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Broader (3)
Antineoplastic Agents, Hormonal
Appetite Stimulants
Megestrol
Narrower (5)
Borea
Megace
Mestrel
Niagestin
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2005
Review
2005
Megestrol acetate for the treatment of anorexia-cachexia syndrome.
E. Berenstein
,
Z. Ortiz
The Cochrane database of systematic reviews
2005
Corpus ID: 25697902
BACKGROUND Megestrol acetate (MA) is currently used to improve appetite and to increase weight in cancer-associated anorexia. In…
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Highly Cited
2004
Highly Cited
2004
An eicosapentaenoic acid supplement versus megestrol acetate versus both for patients with cancer-associated wasting: a North Central Cancer Treatment Group and National Cancer Institute of Canada…
A. Jatoi
,
K. Rowland
,
+9 authors
B. Christensen
Journal of clinical oncology : official journal…
2004
Corpus ID: 24522794
PURPOSE Studies suggest eicosapentaenoic acid (EPA), an omega-3 fatty acid, augments weight, appetite, and survival in cancer…
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Review
2003
Review
2003
Classification and pharmacology of progestins.
A. Schindler
,
C. Campagnoli
,
+4 authors
J. Thijssen
Maturitas
2003
Corpus ID: 35508662
Highly Cited
2002
Highly Cited
2002
Dronabinol versus megestrol acetate versus combination therapy for cancer-associated anorexia: a North Central Cancer Treatment Group study.
A. Jatoi
,
H. Windschitl
,
+9 authors
B. Christensen
Journal of clinical oncology : official journal…
2002
Corpus ID: 22671987
PURPOSE To determine whether dronabinol administered alone or with megestrol acetate was more, less, or equal in efficacy to…
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Review
2002
Review
2002
Cancer Anorexia‐Cachexia Syndrome: Current Issues in Research and Management
A. Inui
CA: a cancer journal for clinicians
2002
Corpus ID: 29298459
Cachexia is among the most debilitating and life‐threatening aspects of cancer. Associated with anorexia, fat and muscle tissue…
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Highly Cited
2001
Highly Cited
2001
Phase III, multicenter, double-blind, randomized study of letrozole, an aromatase inhibitor, for advanced breast cancer versus megestrol acetate.
A. Buzdar
,
J. Douma
,
+7 authors
C. Brady
Journal of clinical oncology : official journal…
2001
Corpus ID: 23545971
PURPOSE To compare two doses of letrozole (0.5 mg and 2.5 mg every day) and megestrol acetate (40 mg qid) as endocrine therapy in…
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Highly Cited
2000
Highly Cited
2000
Exemestane is superior to megestrol acetate after tamoxifen failure in postmenopausal women with advanced breast cancer: results of a phase III randomized double-blind trial. The Exemestane Study…
M. Kaufmann
,
E. Bajetta
,
+14 authors
G. Massimini
Journal of clinical oncology : official journal…
2000
Corpus ID: 24873207
PURPOSE This phase III, double-blind, randomized, multicenter study evaluated the efficacy, pharmacodynamics, and safety of the…
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Highly Cited
1999
Highly Cited
1999
Randomized comparison of megestrol acetate versus dexamethasone versus fluoxymesterone for the treatment of cancer anorexia/cachexia.
C. Loprinzi
,
J. Kugler
,
+7 authors
B. Christensen
Journal of clinical oncology : official journal…
1999
Corpus ID: 43663205
PURPOSE Previous double-blind, placebo-controlled, randomized clinical trials have demonstrated that both corticosteroids and…
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Highly Cited
1998
Highly Cited
1998
Letrozole, a new oral aromatase inhibitor for advanced breast cancer: double-blind randomized trial showing a dose effect and improved efficacy and tolerability compared with megestrol acetate.
P. Dombernowsky
,
I. Smith
,
+15 authors
P. Trunet
Journal of clinical oncology : official journal…
1998
Corpus ID: 40132488
PURPOSE To compare two doses of letrozole and megestrol acetate (MA) as second-line therapy in postmenopausal women with advanced…
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Highly Cited
1998
Highly Cited
1998
Anastrozole versus megestrol acetate in the treatment of postmenopausal women with advanced breast carcinoma
A. Buzdar
,
W. Jonat
,
+8 authors
David Lee
Cancer
1998
Corpus ID: 35131595
This report presents the results of a survival update based on the combined data from two studies that compared the efficacy and…
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