Megestrol Acetate

Known as: 6-Methyl-delta-4,6-pregnadien-17 alpha-ol-3,20-dione Acetate, 17alpha-Hydroxy-6-methylpregna-4,6-diene-3,20-dione acetate, 17?-Hydroxy-6-methylpregna-4,6-diene-3,20-dione acetate 
The acetate salt form of megestrol, a synthetic derivative of the naturally occurring female sex hormone progesterone with potential anti-estrogenic… (More)
National Institutes of Health

Related topics

Related topics

23 relations
AnorexiaCachexiaDrug AllergyEndometrial Neoplasms
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Broader (3)

Antineoplastic Agents, HormonalAppetite StimulantsMegestrol

Narrower (3)

BoreaMegaceNiagestin

Papers overview

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Highly Cited
2004
Highly Cited
2004
An eicosapentaenoic acid supplement versus megestrol acetate versus both for patients with cancer-associated wasting: a North Central Cancer Treatment Group and National Cancer Institute of Canada…
PURPOSE Studies suggest eicosapentaenoic acid (EPA), an omega-3 fatty acid, augments weight, appetite, and survival in cancer… (More)
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Highly Cited
2002
Highly Cited
2002
Dronabinol versus megestrol acetate versus combination therapy for cancer-associated anorexia: a North Central Cancer Treatment Group study.
PURPOSE To determine whether dronabinol administered alone or with megestrol acetate was more, less, or equal in efficacy to… (More)
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Highly Cited
2001
Highly Cited
2001
Phase III, multicenter, double-blind, randomized study of letrozole, an aromatase inhibitor, for advanced breast cancer versus megestrol acetate.
PURPOSE To compare two doses of letrozole (0.5 mg and 2.5 mg every day) and megestrol acetate (40 mg qid) as endocrine therapy in… (More)
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Highly Cited
2000
Highly Cited
2000
Exemestane is superior to megestrol acetate after tamoxifen failure in postmenopausal women with advanced breast cancer: results of a phase III randomized double-blind trial. The Exemestane Study…
PURPOSE This phase III, double-blind, randomized, multicenter study evaluated the efficacy, pharmacodynamics, and safety of the… (More)
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Highly Cited
1999
Highly Cited
1999
Randomized comparison of megestrol acetate versus dexamethasone versus fluoxymesterone for the treatment of cancer anorexia/cachexia.
PURPOSE Previous double-blind, placebo-controlled, randomized clinical trials have demonstrated that both corticosteroids and… (More)
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1999
1999
Megestrol acetate therapy and secondary adrenal suppression.
BACKGROUND Adrenal suppression has been noted in patients who are receiving medroxyprogesterone acetate (MPA). Megestrol acetate… (More)
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Highly Cited
1999
Highly Cited
1999
A prospective randomized study of megestrol acetate and ibuprofen in gastrointestinal cancer patients with weight loss
SummaryThe use of megestrol acetate in the treatment of weight loss in gastrointestinal cancer patients has been disappointing… (More)
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Highly Cited
1998
Highly Cited
1998
Letrozole, a new oral aromatase inhibitor for advanced breast cancer: double-blind randomized trial showing a dose effect and improved efficacy and tolerability compared with megestrol acetate.
PURPOSE To compare two doses of letrozole and megestrol acetate (MA) as second-line therapy in postmenopausal women with advanced… (More)
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Highly Cited
1993
Highly Cited
1993
Body-composition changes in patients who gain weight while receiving megestrol acetate.
PURPOSE Randomized placebo-controlled clinical trials have now established that megestrol acetate causes appetite stimulation and… (More)
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Highly Cited
1990
Highly Cited
1990
Controlled trial of megestrol acetate for the treatment of cancer anorexia and cachexia.
Preliminary information has suggested that megestrol acetate leads to appetite stimulation and nonfluid weight gain in patients… (More)
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