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A prognostic index for thyroid carcinoma. A study of the E.O.R.T.C. Thyroid Cancer Cooperative Group.
Estrogen, androgen, glucocorticoid, and progesterone receptors in progestin-induced regression of human breast cancer.
- F. Teulings, H. van Gilse, M. Henkelman, H. Portengen, J. Alexieva-Figusch
- Biology, MedicineCancer research
- 1 July 1980
It is demonstrated that the progestins megestrol acetate and medroxyprogesterone acetate are strong competitors for steroids which bind specifically to androgen, glucocorticoid, and progesterone receptors, indicating that the PROGestins are able to bind to these receptors with high affinity.
Progestin therapy in advanced breast cancer: Megestrol acetate—an evaluation of 160 treated cases
- J. Alexieva-Figusch, H. van Gilse, W. Hop, C. H. Phoa, J. Blonk‐v. d. Wijst, R. Treurniet
- 1 December 1980
Megesterol acetate therapy may be the first choice of treatment in late postmenopausal patients with soft tissue and lung metastases and no great differences in remission rates were found between patients treated with megestrol acetate as the first hormonal treatment and those previously treated with hormones.
Treatment of metastatic breast cancer patients with different dosages of megestrol acetate; dose relations, metabolic and endocrine effects.
Investigations on the nutritional status of advanced breast cancer patients. The influence of long-term treatment with megestrol acetate or tamoxifen.
The nutritional status of all patients is reasonably adequate, and LH, FSH, and prolactin in plasma and excretion of steroids in 24-hour urine showed levels that could be expected for controls and for untreated and hormonally treated patients.
[Post-partum hypopituitarism; report on 14 cases].
Quantitation of estrogen receptors in human breast cancer by agar gel electrophoresis.
Endocrine effects of aminoglutethimide plus hydrocortisone versus effects of high dose of hydrocortisone alone in postmenopausal metastatic breast cancer.
Demonstration of glucocorticoid receptors in human mammary carcinomas.
A 3H-dexamethasone-binding component in the cytoplasmatic fraction of human breast cancers was studied by agar-gel electrophoresis and satisfied the steroid-hormone receptor criteria in being a high affinity, low capacity binder.
Steroid receptors in megestrol acetate therapy.
- J. Alexieva-Figusch, F. Teulings, W. Hop, J. Blonk-van der Wijst, H. van Gilse
- Biology, MedicineRecent results in cancer research. Fortschritte…
It was demonstrated that megestrol and medroxyprogesterone acetates are strong competitors for steroids which bind specifically to androgen, glucocorticoid, and progesterone receptors, indicating that these progestins are able to bind to these receptors with high affinity.