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A prognostic index for thyroid carcinoma. A study of the E.O.R.T.C. Thyroid Cancer Cooperative Group.
TLDR
A simple prognostic index based on a multivariate analysis using a Weibull survival model is presented which allows one to assess the joint effects of the prognostic variables and indentifies patients with markedly different survival probabilities. Expand
Estrogen, androgen, glucocorticoid, and progesterone receptors in progestin-induced regression of human breast cancer.
TLDR
It is demonstrated that the progestins megestrol acetate and medroxyprogesterone acetate are strong competitors for steroids which bind specifically to androgen, glucocorticoid, and progesterone receptors, indicating that the PROGestins are able to bind to these receptors with high affinity. Expand
Progestin therapy in advanced breast cancer: Megestrol acetate—an evaluation of 160 treated cases
TLDR
Megesterol acetate therapy may be the first choice of treatment in late postmenopausal patients with soft tissue and lung metastases and no great differences in remission rates were found between patients treated with megestrol acetate as the first hormonal treatment and those previously treated with hormones. Expand
Treatment of metastatic breast cancer patients with different dosages of megestrol acetate; dose relations, metabolic and endocrine effects.
TLDR
Treatment of metastatic breast cancer with 180 mg MA/day is effective and causes minimal adverse effects and significant rises of the basal and TRH-stimulated plasma PRL and basal insulin levels were observed, whereas LH and FSH, estradiol, SHBG and the pituitary-adrenal axis were suppressed. Expand
Investigations on the nutritional status of advanced breast cancer patients. The influence of long-term treatment with megestrol acetate or tamoxifen.
TLDR
The nutritional status of all patients is reasonably adequate, and LH, FSH, and prolactin in plasma and excretion of steroids in 24-hour urine showed levels that could be expected for controls and for untreated and hormonally treated patients. Expand
Demonstration of glucocorticoid receptors in human mammary carcinomas.
TLDR
A 3H-dexamethasone-binding component in the cytoplasmatic fraction of human breast cancers was studied by agar-gel electrophoresis and satisfied the steroid-hormone receptor criteria in being a high affinity, low capacity binder. Expand
Quantitation of estrogen receptors in human breast cancer by agar gel electrophoresis.
TLDR
Estrogen receptor and tissue protein contents of the tumors seem to be related to the age of the patients, and Objective remissions with endocrine therapy were obtained in patients with carcinomas which possessed a substantial concentration of estrogen receptors. Expand
Endocrine effects of aminoglutethimide plus hydrocortisone versus effects of high dose of hydrocortisone alone in postmenopausal metastatic breast cancer.
TLDR
It is concluded that both drugs have different effects on the plasma levels of peripheral steroids, and the combination of H + Ag might be preferable, because 'free' oestradiol plasma levels may be lowest after this treatment. Expand
Steroid receptors in megestrol acetate therapy.
TLDR
It was demonstrated that megestrol and medroxyprogesterone acetates are strong competitors for steroids which bind specifically to androgen, glucocorticoid, and progesterone receptors, indicating that these progestins are able to bind to these receptors with high affinity. Expand
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