Mefloquine

Known as: [(R*,S*)-2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol, Mefloquina, Mephloquine 
A quinolinemethanol derivative with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the… (More)
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
BACKGROUND Artemisinin-based combination therapies are the recommended first-line treatments of falciparum malaria in all… (More)
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Highly Cited
2009
Highly Cited
2009
BACKGROUND The treatment and control of schistosomiasis, an often neglected tropical disease that exacerbates poverty, depends on… (More)
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Highly Cited
2008
Highly Cited
2008
Resistance to anti-malarial drugs hampers control efforts and increases the risk of morbidity and mortality from malaria. The… (More)
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Highly Cited
2008
Highly Cited
2008
Resistance to many antimalaria drugs developed on the Cambodia-Thailand border long before developing elsewhere. Because… (More)
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Highly Cited
2007
Highly Cited
2007
Artemisinin combination therapies (ACTs) have recently been adopted as first-line therapy for Plasmodium falciparum infections in… (More)
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Highly Cited
2004
Highly Cited
2004
Recently, great interest has been shown in understanding the functional roles of specific gap junction proteins (connexins) in… (More)
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Highly Cited
2000
Highly Cited
2000
Antimalarial resistance develops and spreads when spontaneously occurring mutant malaria parasites are selected by concentrations… (More)
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Highly Cited
2000
Highly Cited
2000
Following a marked decline in the efficacy in vivo of mefloquine between 1990 and 1994, a combination of artesunate (4 mg/kg/d… (More)
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Highly Cited
1997
Highly Cited
1997
On the western border of Thailand, in an area endemic for multi-drug resistant Plasmodium falciparum malaria, therapeutic… (More)
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Highly Cited
1991
Highly Cited
1991
Mefloquine is the treatment of choice for uncomplicated multiresistant falciparum malaria, and in combination with sulphadoxine… (More)
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