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Mefloquine

Known as: [(R*,S*)-2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol, Mefloquina, Mephloquine 
A quinolinemethanol derivative with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the… 
National Institutes of Health

Related topics

Related topics

22 relations

Broader (1)

Antimalarials
Drug AllergyEpilepsyHalofantrine hydrochlorideIn Blood

Narrower (6)

LariamMefloquine HydrochlorideWR-142,490WR-177,602

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Structure-activity relationships amongst 4-position quinoline methanol antimalarials that inhibit the growth of drug sensitive and resistant strains of Plasmodium falciparum.
Highly Cited
2008
Highly Cited
2008
Antimalarial drugs inhibit human 5‐HT3 and GABAA but not GABAC receptors
Background and purpose: Antimalarial compounds have been previously shown to inhibit rodent nicotinic acetylcholine (nACh) and 5… 
Highly Cited
2000
Highly Cited
2000
Effect of three structurally related antimalarial drugs on liver microsomal components and lipid peroxidation in rats.
Highly Cited
1999
Highly Cited
1999
Analysis of mefloquine resistance and amplification of pfmdr1 in multidrug-resistant Plasmodium falciparum isolates from Thailand.
Resistance to quinoline-containing compound has been associated with the Plasmodium falciparum multidrug resistance 1 (pfmdr1… 
Highly Cited
1993
Highly Cited
1993
Chloroquine-induced inhibition of the production of TNF, but not of IL-6, is affected by disruption of iron metabolism.
1990
1990
Lyme disease transmitted by a biting fly.
Highly Cited
1989
Highly Cited
1989
Alkalinization of the food vacuole of malaria parasites by quinoline drugs and alkylamines is not correlated with their antimalarial activity.
Highly Cited
1989
Highly Cited
1989
Mefloquine and an acute brain syndrome.
Excerpt To the editor:Mefloquine, a quinolinemethanol derivative with a long half-life, is an effective therapy for chloroquine… 
Highly Cited
1987
Highly Cited
1987
A phase-III clinical trial of mefloquine in children with chloroquine-resistant falciparum malaria in Thailand.
Mefloquine is a highly effective drug for the treatment of falciparum malaria among adults, but studies of its effects on… 
Highly Cited
1983
Highly Cited
1983
Plasmodium falciparum: drug sensitivity in vitro of isolates before and after adaptation to continuous culture.
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