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Mefloquine

Known as: [(R*,S*)-2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol, Mefloquina, Mephloquine 
A quinolinemethanol derivative with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the… 
National Institutes of Health

Related topics

Related topics

22 relations

Broader (1)

Antimalarials
Drug AllergyEpilepsyHalofantrine hydrochlorideIn Blood

Narrower (6)

LariamMefloquine HydrochlorideWR-142,490WR-177,602

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Proveblue (Methylene Blue) as an Antimalarial Agent: In Vitro Synergy with Dihydroartemisinin and Atorvastatin
Proveblue (international patent PCT/FR/2007/001193), which is a methylene blue preparation that complies with the European… 
2005
2005
Design, Synthesis and Antimalarial Activity of Trifluoromethylartemisinin–Mefloquine Dual Molecules
Malaria is one of the 'major parasitic diseases in many tropical and subtropical regions, causing more than one million deaths… 
Highly Cited
1999
Highly Cited
1999
Analysis of mefloquine resistance and amplification of pfmdr1 in multidrug-resistant Plasmodium falciparum isolates from Thailand.
Resistance to quinoline-containing compound has been associated with the Plasmodium falciparum multidrug resistance 1 (pfmdr1… 
1998
1998
Lack of efficacy of mefloquine in the treatment of New World cutaneous leishmaniasis in Colombia.
In a nonblinded, therapeutic trial conducted in Colombia, 1.25-1.5 grams of mefloquine base given as a single oral dose or as 250… 
1992
1992
Comparative trial on the response of Plasmodium falciparum to halofantrine and mefloquine in Trat Province, eastern Thailand.
With the appearance of strains of Plasmodium falciparum in the Trat Province, eastern Thailand, reported to have developed… 
1991
1991
The chemotherapy of rodent malaria. XLVI. Reversal of mefloquine resistance in rodent Plasmodium.
Multiple drug resistance in Plasmodium falciparum is already showing evidence of extending to mefloquine, which at present is one… 
1990
1990
Lyme disease transmitted by a biting fly.
Highly Cited
1989
Highly Cited
1989
Mefloquine and an acute brain syndrome.
Excerpt To the editor:Mefloquine, a quinolinemethanol derivative with a long half-life, is an effective therapy for chloroquine… 
Highly Cited
1986
Highly Cited
1986
Sensitivity to quinine and mefloquine of Plasmodium falciparum in Thailand.
Between 1982 and 1984 a regimen consisting of quinine and tetracycline was routinely used in Thailand to treat outpatients with… 
Highly Cited
1985
Highly Cited
1985
Cloning and characterization of mefloquine-resistant Plasmodium falciparum from Thailand.
Resistance to mefloquine in Plasmodium falciparum has begun to occur along the border of Thailand and Kampuchea. As a means of… 
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