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Severe Imported Falciparum Malaria: A Cohort Study in 400 Critically Ill Adults
In a large population of adults treated in a non-endemic industrialized country, severe malaria still carried a high mortality rate, and the data, including predictors of death, can probably be generalized to other non- endemic countries where high-quality healthcare is available.
The clinical spectrum of severe imported falciparum malaria in the intensive care unit: report of 188 cases in adults.
- F. Bruneel, L. Hocqueloux, F. Vachon
- MedicineAmerican journal of respiratory and critical care…
- 1 March 2003
The main factors associated with death in the severe malaria group were the Simplified Acute Physiology Score, shock, acidosis, coma, pulmonary edema, and coagulation disorders and bacterial coinfection.
A shared Asian origin of the triple-mutant dhfr allele in Plasmodium falciparum from sites across Africa.
Migration of parasites carrying an ancestral triple-mutant dhfr allele drives the spread of dhfr alleles associated with pyrimethamine resistance throughout West and Central Africa.
Pfmdr1 copy number and arteminisin derivatives combination therapy failure in falciparum malaria in Cambodia
This study shows that pfmdr1 copy number is a molecular marker of AM treatment failure in falciparum malaria on the Thai-Cambodian border, however, while it is associated with increased IC50 for lumefantrine, pfmDr1copy number is not associated with AL treatment failure on the area, suggesting involvement of other molecular mechanisms in AL treatment failures in Cambodia.
Analysis of pfmdr1 and drug susceptibility in fresh isolates of Plasmodium falciparum from subsaharan Africa.
Clinical atovaquone-proguanil resistance of Plasmodium falciparum associated with cytochrome b codon 268 mutations.
Chimpanzee Malaria Parasites Related to Plasmodium ovale in Africa
This study provides the first evidence of possibility of natural cross-species exchange of P. ovale between humans and chimpanzees of the subspecies Pan t.
DHFR and DHPS genotypes of Plasmodium falciparum isolates from Gabon correlate with in vitro activity of pyrimethamine and cycloguanil, but not with sulfadoxine-pyrimethamine treatment efficacy.
- A. Aubouy, S. Jafari, P. Deloron
- Medicine, BiologyThe Journal of antimicrobial chemotherapy
- 1 July 2003
DHFR mutations that lead to high-level in vitro resistance to pyrimethamine plus 1-2 DHPS mutations are not sufficient to induce in vivo failure of SP treatment in young children from Gabon.
Assessment of the Drug Susceptibility of Plasmodium falciparum Clinical Isolates from Africa by Using a Plasmodium Lactate Dehydrogenase Immunodetection Assay and an Inhibitory Maximum Effect Model…
- H. Kaddouri, Serge Nakache, S. Houzé, F. Mentré, J. Le bras
- Medicine, BiologyAntimicrobial Agents and Chemotherapy
- 1 October 2006
This evaluation evaluated a commercially controlled pLDH enzyme-linked immunosorbent assay (ELISA) to assess drug susceptibility in a standard in vitro assay using fairly basic laboratory equipment to study the in vitro resistance of malaria parasites to major antimalarials.
In vitro activities of furoquinoline and acridone alkaloids against Plasmodium falciparum
In vitro activities of furo[2,3b]quinoline and acridone alkaloids against Plasmodium falciparum were evaluated and a pyran ring in the furoquinoline nucleus and 2-O-pyranoglycoside and2-nitro substituents in the acrid one nucleus improved the antimalarial activities of the compounds.