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Halofantrine hydrochloride

Known as: 1-(1,3-dichloro-6-trifluoromethyl-9-phenanthryl)-3-di(n-butyl)aminopropanol HCl 
 
National Institutes of Health

Related topics

Related topics

12 relations
AntimalarialsDrug AllergyMalariaMalaria, Falciparum
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Narrower (2)

HalfanWR 171,699

Broader (1)

halofantrine

Papers overview

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2001
2001
Stereoselective halofantrine disposition and effect: concentration-related QTc prolongation.
AIMS 1) To characterize the variability of multiple-dose halofantrine pharmacokinetics over time in healthy adults, 2) to… Expand
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1998
1998
Halofantrine and chloroquine inhibit CYP2D6 activity in healthy Zambians.
AIMS To determine the effect of therapeutic loading doses of halofantrine and chloroquine on CYP2D6 activity in healthy black… Expand
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Highly Cited
1996
Highly Cited
1996
A physicochemical basis for the effect of food on the absolute oral bioavailability of halofantrine.
Halofantrine hydrochloride (Hf.HCl) is a highly lipophilic phenanthrenemethanol antimalarial. The poor and erratic absorption of… Expand
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Highly Cited
1996
Highly Cited
1996
Lymphatic transport of halofantrine in the triple-cannulated anesthetized rat model: effect of lipid vehicle dispersion.
Halofantrine hydrochloride is an important, highly lipophilic anti-malarial agent. A triple-cannulated anesthetized rat model was… Expand
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1996
1996
Cardiac effects of standard-dose halofantrine therapy.
The antimalarial drug halofantrine hydrochloride has been associated with cardiac arrhythmias. This is a report of a study on the… Expand
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Highly Cited
1995
Highly Cited
1995
Clinical characteristics of neonatal malaria.
The clinical characteristics of 16 neonates with malaria parasitaemia diagnosed on Giemsa stained smears were documented during a… Expand
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1993
1993
Pharmacokinetics, efficacy and toxicity of parenteral halofantrine in uncomplicated malaria.
1 The pharmacokinetics, efficacy and toxicity of a new parenteral formulation of halofantrine hydrochloride were evaluated in 12… Expand
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1990
1990
Evaluation of the clinical efficacy and safety of halofantrine in falciparum malaria in Ibadan, Nigeria.
Fifty subjects with acute symptomatic uncomplicated falciparum malaria were treated orally with halofantrine hydrochloride 500 mg… Expand
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1989
1989
The efficacy of halofantrine hydrochloride in acute malaria: A study of 74 patients from Karachi, Pakistan
Summary Forty-three adults with P. falciparum and 31 with P. vivax infections were treated with 500 mg halofantrine 6 hourly for… Expand
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1988
1988
CLINICAL TRIALS WITH HALOFANTRINE HYDROCHLORIDE IN MALAWI
Two clinical trials of the phenanthrene methanol compound halofantrine in the treatment of Plasmodium falciparum were conducted… Expand
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