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Halofantrine hydrochloride

Known as: 1-(1,3-dichloro-6-trifluoromethyl-9-phenanthryl)-3-di(n-butyl)aminopropanol HCl 
 
National Institutes of Health

Papers overview

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2001
2001
AIMS 1) To characterize the variability of multiple-dose halofantrine pharmacokinetics over time in healthy adults, 2) to… Expand
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1998
1998
AIMS To determine the effect of therapeutic loading doses of halofantrine and chloroquine on CYP2D6 activity in healthy black… Expand
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Highly Cited
1996
Highly Cited
1996
Halofantrine hydrochloride (Hf.HCl) is a highly lipophilic phenanthrenemethanol antimalarial. The poor and erratic absorption of… Expand
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Highly Cited
1996
Highly Cited
1996
Halofantrine hydrochloride is an important, highly lipophilic anti-malarial agent. A triple-cannulated anesthetized rat model was… Expand
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1996
1996
The antimalarial drug halofantrine hydrochloride has been associated with cardiac arrhythmias. This is a report of a study on the… Expand
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Highly Cited
1995
Highly Cited
1995
The clinical characteristics of 16 neonates with malaria parasitaemia diagnosed on Giemsa stained smears were documented during a… Expand
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1993
1993
1 The pharmacokinetics, efficacy and toxicity of a new parenteral formulation of halofantrine hydrochloride were evaluated in 12… Expand
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1990
1990
Fifty subjects with acute symptomatic uncomplicated falciparum malaria were treated orally with halofantrine hydrochloride 500 mg… Expand
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1989
1989
Summary Forty-three adults with P. falciparum and 31 with P. vivax infections were treated with 500 mg halofantrine 6 hourly for… Expand
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1988
1988
Two clinical trials of the phenanthrene methanol compound halofantrine in the treatment of Plasmodium falciparum were conducted… Expand
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