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Halofantrine hydrochloride

Known as: 1-(1,3-dichloro-6-trifluoromethyl-9-phenanthryl)-3-di(n-butyl)aminopropanol HCl 
National Institutes of Health

Related topics

Related topics

12 relations
AntimalarialsDrug AllergyMalariaMalaria, Falciparum

Narrower (2)

HalfanWR 171,699

Broader (1)

halofantrine

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2001
2001
Stereoselective halofantrine disposition and effect: concentration-related QTc prolongation.
AIMS 1) To characterize the variability of multiple-dose halofantrine pharmacokinetics over time in healthy adults, 2) to… 
1999
1999
Differences in the lipoprotein distribution of halofantrine are regulated by lipoprotein apolar lipid and protein concentration and lipid transfer protein I activity: in vitro studies in…
The purpose of these studies was to determine the distribution of a lipophilic antimalarial agent, halofantrine hydrochloride (Hf… 
1998
1998
Halofantrine and chloroquine inhibit CYP2D6 activity in healthy Zambians.
AIMS To determine the effect of therapeutic loading doses of halofantrine and chloroquine on CYP2D6 activity in healthy black… 
Highly Cited
1996
Highly Cited
1996
Lymphatic transport of halofantrine in the triple-cannulated anesthetized rat model: effect of lipid vehicle dispersion.
Halofantrine hydrochloride is an important, highly lipophilic anti-malarial agent. A triple-cannulated anesthetized rat model was… 
Highly Cited
1996
Highly Cited
1996
A physicochemical basis for the effect of food on the absolute oral bioavailability of halofantrine.
Halofantrine hydrochloride (Hf.HCl) is a highly lipophilic phenanthrenemethanol antimalarial. The poor and erratic absorption of… 
1996
1996
Cardiac effects of standard-dose halofantrine therapy.
The antimalarial drug halofantrine hydrochloride has been associated with cardiac arrhythmias. This is a report of a study on the… 
Highly Cited
1995
Highly Cited
1995
Clinical characteristics of neonatal malaria.
The clinical characteristics of 16 neonates with malaria parasitaemia diagnosed on Giemsa stained smears were documented during a… 
1993
1993
Pharmacokinetics, efficacy and toxicity of parenteral halofantrine in uncomplicated malaria.
1 The pharmacokinetics, efficacy and toxicity of a new parenteral formulation of halofantrine hydrochloride were evaluated in 12… 
1990
1990
Clinical experience with halofantrine in the treatment of malaria.
Halofantrine hydrochloride (HF) belongs to a new class of antimalarials, the phenanthrene methanols. Preliminary clinical studies… 
1988
1988
CLINICAL TRIALS WITH HALOFANTRINE HYDROCHLORIDE IN MALAWI
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