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Mechlorethamine hydrochloride

Known as: Chloromethine HCl, Methylbis(beta-chloroethyl)amine Hydrochloride, ethanamine,2-chloro-N-(2-chloroethyl)-N-methyl Hydrochloride 
The hydrochloride salt of mechlorethamine, a nitrogen mustard and an analogue of sulfur mustard, with antineoplastic and immunosuppressive activities… 
National Institutes of Health

Related topics

Related topics

33 relations
Alkylating Activity [MoA]Communicable DiseasesCyclophosphamide/Mechlorethamine/Prednisone/Procarbazine/Vincristine protocolDrug Allergy

Narrower (4)

CaryolysineCloraminErasolMustargen

Broader (2)

Mustard CompoundsNitrogen Mustard Compounds

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Topical chemotherapy in cutaneous T-cell lymphoma: positive results of a randomized, controlled, multicenter trial testing the efficacy and safety of a novel mechlorethamine, 0.02%, gel in mycosis…
OBJECTIVE To evaluate the efficacy and safety of a novel mechlorethamine hydrochloride, 0.02%, gel in mycosis fungoides. DESIGN… 
Review
2011
Review
2011
Extravasation management: clinical update.
Highly Cited
2008
Highly Cited
2008
Phase II multicenter study of bendamustine plus rituximab in patients with relapsed indolent B-cell and mantle cell non-Hodgkin's lymphoma.
PURPOSE Bendamustine HCl is a bifunctional mechlorethamine derivative with clinical activity in the treatment of non-Hodgkin's… 
Highly Cited
1996
Highly Cited
1996
Clinical stage IA (limited patch and plaque) mycosis fungoides. A long-term outcome analysis.
OBJECTIVES To study the long-term results of treatment of patients with stage IA mycosis fungoides and analyze the factors… 
Review
1992
Review
1992
The molecular pharmacology of L-deprenyl.
Highly Cited
1989
Highly Cited
1989
Induction of fos RNA by DNA-damaging agents.
We have found that a wide variety of DNA-damaging agents and heat shock increase fos RNA to different extents in Chinese hamster… 
Highly Cited
1988
Highly Cited
1988
Topical mechlorethamine therapy for early stage mycosis fungoides.
Highly Cited
1985
Highly Cited
1985
Macrophage-induced glomerular fibrin deposition in experimental glomerulonephritis in the rabbit.
Glomerular fibrin deposition is important in the pathogenesis of renal failure and crescent formation in glomerulonephritis. The… 
Highly Cited
1981
Highly Cited
1981
Leukocytes Are Required for Increased Lung Microvascular Permeability after Microembolization in Sheep
We studied the effects of uneven pulmonary artery obstruction by microemboli on steady state transvascular fluid and protein… 
Highly Cited
1970
Highly Cited
1970
Combination Chemotherapy in Generalized Hodgkin's Disease
Fifty-two patients with generalized Hodgkin's disease were treated with a combination of mustine hydrochloride, vinblastine… 
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