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Maturation-Promoting Factor

Known as: MPF, M-Phase-Promoting Factor, M Phase Promoting Factor 
M Phase-Promoting Factor is a protein kinase complex that drives both the mitotic and meiotic cycles in all eukaryotic organisms. In meiosis it… Expand
National Institutes of Health

Related topics

Related topics

21 relations
CDC2 Protein KinaseChromosome CondensationCyclin B1Cyclins
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Broader (1)

Cell Cycle Proteins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2008
Review
2008
Regulation of oocyte maturation in fish
A period of oocyte growth is followed by a process called oocyte maturation (the resumption of meiosis) which occurs prior to… Expand
Highly Cited
1998
Highly Cited
1998
MPF localization is controlled by nuclear export
A.Hagting and C.Karlsson contributed equally to this work 
Highly Cited
1991
Highly Cited
1991
Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport
We have used immunofluorescence staining to study the subcellular distribution of cyclin A and B1 during the somatic cell cycle… Expand
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Highly Cited
1990
Highly Cited
1990
Cyclin is a component of maturation-promoting factor from Xenopus
Highly purified maturation-promoting factor (MPF) from Xenopus eggs contains both cyclin B1 and cyclin B2 as shown by Western… Expand
Highly Cited
1990
Highly Cited
1990
Human cyclin A is adenovirus E1A-associated protein p60 and behaves differently from cyclin B
CYCLINS are proteins synthesized during each cell cycle and abruptly destroyed in each mitosis1–5. Cyclins have been implicated… Expand
Highly Cited
1989
Highly Cited
1989
The role of cyclin synthesis and degradation in the control of maturation promoting factor activity
We show that cyclin plays a pivotal role in the control of mitosis. A proteolysis-resistant mutant of cyclin prevents the… Expand
Highly Cited
1989
Highly Cited
1989
cdc2 protein kinase is complexed with both cyclin A and B: Evidence for proteolytic inactivation of MPF
In the clam, Spisula, two previously described proteins known as cyclin A and B display the unusual property of selective… Expand
Highly Cited
1988
Highly Cited
1988
Purification of maturation-promoting factor, an intracellular regulator of early mitotic events.
Maturation-promoting factor causes germinal vesicle breakdown when injected into Xenopus oocytes and can induce metaphase in a… Expand
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Highly Cited
1988
Highly Cited
1988
Regulation of meiotic metaphase by a cytoplasmic maturation-promoting factor during mouse oocyte maturation.
During mouse oocyte maturation the regulation of the activity of a cytoplasmic maturation-promoting factor (MPF) was examined… Expand
Highly Cited
1971
Highly Cited
1971
Cytoplasmic control of nuclear behavior during meiotic maturation of frog oocytes.
Fully grown oocytes of the frog (Rana pipiens) undergo cytoplasmic and nuclear maturation when treated with progesterone after… Expand
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