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Cyclin B1

Known as: G2/Mitotic-Specific Cyclin-B1, CCNB1, Cyclin-B1 
G2/mitotic-specific cyclin-B1 (433 aa, ~48 kDa) is encoded by the human CCNB1 gene. This protein plays a role in mediating the progression of the… 
National Institutes of Health

Related topics

Related topics

24 relations
CCNB1 geneCCNB1 wt AlleleCell CycleCell Cycle Control

Broader (2)

Cyclin BProliferating Cell Nuclear Antigen

Papers overview

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Highly Cited
2009
Highly Cited
2009
Integrative Analysis of Cyclin Protein Levels Identifies Cyclin B1 as a Classifier and Predictor of Outcomes in Breast Cancer
Purpose: We studied the expression levels of cyclins B1, D1, and E1 and the implications of cyclin overexpression for patient… 
Highly Cited
2008
Highly Cited
2008
Targeting cyclin B1 inhibits proliferation and sensitizes breast cancer cells to taxol
BackgroundCyclin B1, the regulatory subunit of cyclin-dependent kinase 1 (Cdk1), is essential for the transition from G2 phase to… 
Highly Cited
2004
Highly Cited
2004
Cyclin B1 depletion inhibits proliferation and induces apoptosis in human tumor cells
Cyclin B1 is the regulatory subunit of M-phase promoting factor, and proper regulation of cyclin B1 is essential for the… 
Review
2003
Review
2003
Cyclin B1 and CDK1: nuclear localization and upstream regulators.
Formation of an active nuclear cyclin B1-CDK1 complex is a highly intricate procedure requiring many different levels of… 
Highly Cited
2001
Highly Cited
2001
Polo-like kinase 1 phosphorylates cyclin B1 and targets it to the nucleus during prophase
In vertebrate cells, the nuclear entry of Cdc2–cyclin B1 (MPF) during prophase is thought to be essential for the induction and… 
Highly Cited
2001
Highly Cited
2001
Patched1 interacts with cyclin B1 to regulate cell cycle progression
The initiation of mitosis requires the activation of M‐phase promoting factor (MPF). MPF activation and its subcellular… 
Highly Cited
1998
Highly Cited
1998
Nuclear export of cyclin B1 and its possible role in the DNA damage‐induced G2 checkpoint
M‐phase‐promoting factor (MPF), a complex of cdc2 and a B‐type cyclin, is a key regulator of the G2/M cell cycle transition… 
Highly Cited
1998
Highly Cited
1998
Control of cyclin B1 localization through regulated binding of the nuclear export factor CRM1.
Activation of the Cyclin B/Cdc2 kinase complex triggers entry into mitosis in all eukaryotic cells. Cyclin B1 localization… 
Highly Cited
1998
Highly Cited
1998
Cyclin B2-null mice develop normally and are fertile whereas cyclin B1-null mice die in utero.
Two B-type cyclins, B1 and B2, have been identified in mammals. Proliferating cells express both cyclins, which bind to and… 
Highly Cited
1997
Highly Cited
1997
Nuclear localization of cyclin B1 mediates its biological activity and is regulated by phosphorylation.
M-phase promoting factor or maturation promoting factor, a key regulator of the G2-->M transition of the cell cycle, is a complex… 
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