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Matrix Metalloproteinase 13

Known as: Metalloproteinase, MMP13, Metalloproteinase-13, Matrix, Collagenase 3 
A secreted matrix metalloproteinase that plays a physiological role in the degradation of extracellular matrix found in skeletal tissues. It is… 
National Institutes of Health

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In BloodMMP-13 activityMMP13 geneProcess of secretion

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MMP13 protein, humanMmp13 protein, mouse

Papers overview

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2016
2016
Selective regulation of Mmp13 by 1,25(OH)2D3, PTH, and Osterix through distal enhancers
Highly Cited
2009
Highly Cited
2009
Discoidin domain receptor 2 is associated with the increased expression of matrix metalloproteinase-13 in synovial fibroblasts of rheumatoid arthritis
Regulation of matrix metalloproteinase-13 (MMP-13) by collagen matrix in the synovial fibroblasts of rheumatoid arthritis (RA) is… 
Highly Cited
2002
Highly Cited
2002
Expression of collagenase‐3 (MMP‐13) enhances invasion of human fibrosarcoma HT‐1080 cells
Collagenase‐3 (MMP‐13) is characterized by an exceptionally wide substrate specificity and restricted expression. MMP‐13 is 1 of… 
2002
2002
A novel negative regulatory element in the human collagenase-3 proximal promoter region.
We have identified in the human collagenase-3 promoter a novel negative regulatory element, GAAAAGAAAAAG, designated AGRE (AG… 
2001
2001
Enzymes active in the areas undergoing cartilage resorption during the development of the secondary ossification center in the tibiae of rats aged 0–21 days. II. Two proteinases, gelatinase B and…
In the transformation of the cartilaginous epiphysis into bone, the first indication of change in the surfaces destined for… 
2000
2000
Epidermal growth factor and basic fibroblast growth factor increase the production of matrix metalloproteinases during in vitro decidualization of rat endometrial stromal cells.
Numerous growth factors are involved in mediating proliferation and differentiation of endometrial stromal cells during… 
2000
2000
Regulation of collagenase‐3 gene expression in osteoblastic and non‐osteoblastic cell lines
Collagenase‐3 expression in osteoblastic (UMR 106‐01, ROS 17/2.8) and non‐osteoblastic cell lines (BC1, NIH3T3) was examined. We… 
1999
1999
Skeletal bone morphogenetic proteins suppress the expression of collagenase-3 by rat osteoblasts.
Bone morphogenetic proteins (BMPs) are secreted by skeletal cells, induce the differentiation of mesenchymal cells into cells of… 
1999
1999
Collagenase specificity in chondrosarcoma metastasis.
The treatment of some mesenchymal malignancies has made significant gains over the past few decades with the development of… 
Highly Cited
1995
Highly Cited
1995
The human collagenase-3 (CLG3) gene is located on chromosome 11q22.3 clustered to other members of the matrix metalloproteinase gene family.
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