Matrix Metalloproteinase 13

Known as: Metalloproteinase, MMP13, Metalloproteinase-13, Matrix, Collagenase 3 
A secreted matrix metalloproteinase that plays a physiological role in the degradation of extracellular matrix found in skeletal tissues. It is… (More)
National Institutes of Health

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In BloodMMP-13 activityMMP13 geneProcess of secretion
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MMP13 protein, humanMmp13 protein, mouse

Papers overview

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Highly Cited
2007
Highly Cited
2007
Tumor-derived Matrix Metalloproteinase-13 (MMP-13) correlates with poor prognoses of invasive breast cancer
Experimental evidence suggests that matrix metalloproteinase-13 (MMP-13) protein may promote breast tumor progression, however… (More)
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2005
2005
Increased matrix metalloproteinase-13 production with aging by human articular chondrocytes in response to catabolic stimuli.
Chondrocyte anabolic activity has been shown to decline with aging, but catabolic activity has received little attention. In this… (More)
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Highly Cited
2004
Highly Cited
2004
Matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase mRNA levels are specifically altered in torn rotator cuff tendons.
BACKGROUND Rotator cuff tears are a cause of pain and disability in the shoulder. The molecular changes associated with rotator… (More)
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2004
2004
Collagenolysis-dependent angiogenesis mediated by matrix metalloproteinase-13 (collagenase-3).
We have demonstrated previously that new blood vessel formation induced by angiogenic growth factors in onplants placed on the… (More)
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Highly Cited
2003
Highly Cited
2003
Induction of matrix metalloproteinase-13 gene expression by TNF-alpha is mediated by MAP kinases, AP-1, and NF-kappaB transcription factors in articular chondrocytes.
Tumor necrosis factor alpha (TNF-alpha), a major proinflammatory cytokine, induces arthritic joint inflammation and resorption of… (More)
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Highly Cited
2001
Highly Cited
2001
Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice.
It has been suggested that increased collagenase-3 (MMP-13) activity plays a pivotal role in the pathogenesis of osteoarthritis… (More)
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Highly Cited
1999
Highly Cited
1999
Evidence for increased collagenolysis by interstitial collagenases-1 and -3 in vulnerable human atheromatous plaques.
BACKGROUND Several recent studies attempted to classify plaques as those prone to cause clinical manifestations (vulnerable… (More)
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Highly Cited
1997
Highly Cited
1997
Expression of collagenase-3 (matrix metalloproteinase-13) in squamous cell carcinomas of the head and neck.
Squamous cell carcinomas (SCCs) of the head and neck are malignant tumors with high capacity to invade and metastasize. We have… (More)
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Highly Cited
1997
Highly Cited
1997
Collagenase-3 (MMP-13) is expressed by hypertrophic chondrocytes, periosteal cells, and osteoblasts during human fetal bone development.
Collagenase-3 (MMP-13) is a novel matrix metalloproteinase, the expression of which has so far only been documented in human… (More)
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Highly Cited
1996
Highly Cited
1996
Degradation of cartilage aggrecan by collagenase-3 (MMP-13).
Degradation of the large cartilage proteoglycan aggrecan in arthritis involves an unidentified enzyme aggrecanase, and at least… (More)
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